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dc.contributor.authorHermansen, Johanne Uthus
dc.contributor.authorWojcik, Dorota
dc.contributor.authorRobinson, Nina
dc.contributor.authorPahnke, Jens
dc.contributor.authorHaugland, Hans Kristian
dc.contributor.authorJamtøy, Ann-Helen
dc.contributor.authorFlægstad, Trond
dc.contributor.authorHalvorsen, Hanne
dc.contributor.authorLund, Bendik
dc.contributor.authorBaumbusch, Lars Oliver
dc.contributor.authorMunthe-Kaas, Monica Cheng
dc.date.accessioned2021-11-16T13:04:09Z
dc.date.available2021-11-16T13:04:09Z
dc.date.created2021-10-13T16:49:07Z
dc.date.issued2021
dc.identifier.citationCancer Reports. 2021, 1-8.en_US
dc.identifier.issn2573-8348
dc.identifier.urihttps://hdl.handle.net/11250/2829866
dc.description.abstractBackground The rapidly expanding era of “omics” research is highly dependent on the availability of quality-proven biological material, especially for rare conditions such as pediatric malignancies. Professional biobanks provide such material, focusing on standardized collection and handling procedures, distinctive quality measurements, traceability of storage conditions, and accessibility. For pediatric malignancies, traditional tumor biobanking is challenging due to the rareness and limited amount of tissue and blood samples. The higher molecular heterogeneity, lower mutation rates, and unique genomic landscapes, however, renders biobanking of this tissue even more crucial. Aim The aim of this study was to test and establish methods for a prospective and centralized biobank for infants, children, and adolescents up to 18 years of age diagnosed with cancer in Norway. Methods Obtain judicial and ethical approvals and administration through a consortium, steering committee, and advisory board. Develop pipelines including SOPs for all aspects in the biobank process, including collection, processing and storing of samples and data, as well of quality controlling, safeguarding, distributing, and transport. Results The childhood cancer biobanking started at Oslo University Hospital in March 2017 and was from 2019 run as a national Norwegian Childhood Cancer Biobank. Informed consent and biological samples are collected regionally and stored centrally. Approximately 12 000 samples from 510 patients and have been included by January 1, 2021, representing a 96% consent and participation rate among our newly diagnosed patients. Conclusion A well-functioning nationwide collection and centralized biobank with standardized procedures and national storage for pediatric malignancies has been established with a high acceptance among families.en_US
dc.language.isoengen_US
dc.publisherWileyen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleThe Norwegian childhood cancer biobanken_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.source.pagenumber1-8en_US
dc.source.journalCancer Reportsen_US
dc.identifier.doi10.1002/cnr2.1555
dc.identifier.cristin1945706
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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