dc.contributor.author | Åsberg, Arne | |
dc.contributor.author | Løfblad, Lena | |
dc.contributor.author | Felic, Amela | |
dc.contributor.author | Aune, Marthe Wedø | |
dc.contributor.author | Hov, Gunhild Garmo | |
dc.contributor.author | Fagerli, Unn-Merete | |
dc.date.accessioned | 2021-10-28T09:18:20Z | |
dc.date.available | 2021-10-28T09:18:20Z | |
dc.date.created | 2021-08-16T11:32:22Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Scandinavian Journal of Clinical and Laboratory Investigation. 2021, 81 (4), 303-306. | en_US |
dc.identifier.issn | 0036-5513 | |
dc.identifier.uri | https://hdl.handle.net/11250/2826232 | |
dc.description.abstract | Presently, bed-side or at home quantification of neutrophils in blood (b-neutrophils) is not practical, because cytometric methods are too expensive and technically demanding. We have explored whether calprotectin concentration in whole blood (b-calprotectin) might be a valid measure of b-neutrophils because this principle might be used in a simple and robust immunoassay device. We obtained heparin blood samples from 77 patients with possible neutropenia, most of them cancer patients treated with cytostatic drugs, and compared b-calprotectin with their b-neutrophils in a simultaneously taken EDTA-blood sample. The Spearman rank correlation coefficient between b-calprotectin and b-neutrophils was 0.986 (p < .0001). In a regression model of b-neutrophils as a function of age, gender, type of hematology instrument, total leukocyte count minus neutrophils, b-calprotectin, and plasma calprotectin (p-calprotectin), only b-calprotectin was a statistically significant predictor. B-neutrophils below 1 x 109/L was unlikely if b-calprotectin was above 50 mg/L. In conclusion, b-calprotectin, without adjusting for p-calprotectin, correlates closely with b-neutrophils and could be used to detect b-neutrophils below 1 x 109/L. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Taylor & Francis | en_US |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/deed.no | * |
dc.title | Using blood calprotectin as a measure of blood neutrophils | en_US |
dc.type | Peer reviewed | en_US |
dc.type | Journal article | en_US |
dc.description.version | publishedVersion | en_US |
dc.source.pagenumber | 303-306 | en_US |
dc.source.volume | 81 | en_US |
dc.source.journal | Scandinavian Journal of Clinical and Laboratory Investigation | en_US |
dc.source.issue | 4 | en_US |
dc.identifier.doi | 10.1080/00365513.2021.1904283 | |
dc.identifier.cristin | 1926248 | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |