dc.contributor.author | Skanke, Lars Høsøien | |
dc.contributor.author | Lysvand, Hilde | |
dc.contributor.author | Heimdal, Inger | |
dc.contributor.author | Moe, Nina | |
dc.contributor.author | Krokstad, Sidsel | |
dc.contributor.author | Christensen, Andreas | |
dc.contributor.author | Risnes, Kari | |
dc.contributor.author | Nordbø, Svein Arne | |
dc.contributor.author | Døllner, Henrik | |
dc.date.accessioned | 2021-10-25T12:02:44Z | |
dc.date.available | 2021-10-25T12:02:44Z | |
dc.date.created | 2021-05-10T21:41:43Z | |
dc.date.issued | 2021 | |
dc.identifier.issn | 2048-7193 | |
dc.identifier.uri | https://hdl.handle.net/11250/2825368 | |
dc.description.abstract | Background. The role of Parechovirus A (PeV-A) in hospitalized children with respiratory tract infections (RTIs) is unclear. We studied the occurrence and impact of PeV-A over 10 years. Methods. Children from Sør-Trøndelag County, Norway, hospitalized with RTI and a comparison group of asymptomatic children admitted to elective surgery, were prospectively enrolled from 2006 to 2016. Nasopharyngeal aspirates were cultured and analyzed with polymerase chain reaction tests for PeV-A and 19 other pathogens. The cycle threshold levels of PeV-A were reported as measures of viral genomic loads. Parechovirus A-positive samples were genotyped by amplification and sequencing of the VP3/ VP1 junction. Results. Parechovirus A was detected in 8.8% (323/3689) patients with RTI and in 10.1% (45/444) of the children in the comparison group (P = .34). Parechovirus A genotyping (n = 188) revealed PeV-A1 (n = 121), PeV-A3 (n = 15), PeV-A5 (n = 6), and PeV-A6 (n = 46). Viral codetections occurred in 95% of patients and in 84% of the children in the comparison group (P = .016). In multivariable logistic regression analysis, RTI was unrelated to PeV-A genomic loads, adjusted for other viruses and covariates. Similar results were found for PeV-A1 and PeV-A6. Conclusions. Parechovirus A and viral codetections were common in hospitalized children with RTI and asymptomatic children in a comparison group. Our findings suggest that PeV-A has a limited role in hospitalized children with RTI | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Oxford University Press | en_US |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/deed.no | * |
dc.title | Parechovirus A in Hospitalized Children With Respiratory Tract Infections: A 10-Year-Long Study From Norway | en_US |
dc.type | Peer reviewed | en_US |
dc.type | Journal article | en_US |
dc.description.version | publishedVersion | en_US |
dc.source.journal | Journal of the Pediatric Infectious Diseases Society | en_US |
dc.identifier.doi | 10.1093/jpids/piab009 | |
dc.identifier.cristin | 1909307 | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |