Show simple item record

dc.contributor.authorMunkhaugen, John
dc.contributor.authorRuddox, Vidar
dc.contributor.authorHalvorsen, Sigrun
dc.contributor.authorDammen, Toril
dc.contributor.authorFagerland, Morten
dc.contributor.authorHernæs, Kjersti Helene
dc.contributor.authorVethe, Nils Tore
dc.contributor.authorPrescott, Eva
dc.contributor.authorJensen, Svend Eggert
dc.contributor.authorRødevand, Olaf
dc.contributor.authorJortveit, Jarle
dc.contributor.authorBendz, Bjørn
dc.contributor.authorSchirmer, Henrik
dc.contributor.authorKõber, Lars
dc.contributor.authorBotker, Hans Erik
dc.contributor.authorLarsen, Alf Inge
dc.contributor.authorVikenes, Kjell
dc.contributor.authorSteigen, Terje
dc.contributor.authorWiseth, Rune
dc.contributor.authorPedersen, Terje Rolf
dc.contributor.authorEdvardsen, Thor
dc.contributor.authorOtterstad, Jan Erik
dc.contributor.authorAtar, Dan
dc.identifier.citationAmerican Heart Journal. 2019, 208 37-46.en_US
dc.description.abstractBackground - Current guidelines on the use of β-blockers in post–acute myocardial infarction (MI) patients without reduced left ventricular ejection fraction (LVEF) are based on studies before the implementation of modern reperfusion and secondary prevention therapies. It remains unknown whether β-blockers will reduce mortality and recurrent MI in contemporary revascularized post-MI patients without reduced LVEF. Design - BETAMI is a prospective, randomized, open, blinded end point multicenter study in 10,000 MI patients designed to test the superiority of oral β-blocker therapy compared to no β-blocker therapy. Patients with LVEF ≥40% following treatment with percutaneous coronary intervention or thrombolysis and/or no clinical signs of heart failure are eligible to participate. The primary end point is a composite of all-cause mortality or recurrent MI obtained from national registries over a mean follow-up period of 3 years. Safety end points include rates of nonfatal MI, all-cause mortality, ventricular arrhythmias, and hospitalizations for heart failure obtained from hospital medical records 30 days after randomization, and from national registries after 6 and 18 months. Key secondary end points include recurrent MI, heart failure, cardiovascular and all-cause mortality, and clinical outcomes linked to β-blocker therapy including drug adherence, adverse effects, cardiovascular risk factors, psychosocial factors, and health economy. Statistical analyses will be conducted according to the intention-to-treat principle. A prespecified per-protocol analysis (patients truly on β-blockers or not) will also be conducted. Conclusions - The results from the BETAMI trial may have the potential of changing current clinical practice for treatment with β-blockers following MI in patients without reduced LVEF. EudraCT number 2018-000590-75.en_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internasjonal*
dc.titleBEtablocker Treatment After acute Myocardial Infarction in revascularized patients without reduced left ventricular ejection fraction (BETAMI): Rationale and design of a prospective, randomized, open, blinded end-point studyen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.source.journalAmerican Heart Journalen_US
dc.description.localcode© 2018 Elsevier Inc. All rights reserved. This is the authors' accepted and refereed manuscript to the article.en_US
cristin.unitnameKlinikk for hjertemedisin

Files in this item


This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal