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dc.contributor.authorHuie, Russel J
dc.contributor.authorMondello, Stefania
dc.contributor.authorLindsell, Christopher J.
dc.contributor.authorAntiga, L
dc.contributor.authorYuh, Esther
dc.contributor.authorZanier, Elisa
dc.contributor.authorMasson, Serge
dc.contributor.authorRosario, Bedda
dc.contributor.authorFerguson, Adam
dc.contributor.authorAndelic, Nada
dc.contributor.authorAndreassen, Lasse
dc.contributor.authorAnke, Audny
dc.contributor.authorFrisvold, Shirin
dc.contributor.authorHelseth, Eirik
dc.contributor.authorRøe, Cecilie
dc.contributor.authorRøise, Olav
dc.contributor.authorSkandsen, Toril
dc.contributor.authorVik, Anne
dc.contributor.authorAckerlund, Cecilia
dc.contributor.authorAdams, Hadie
dc.contributor.authorAgnoletti, Vanni
dc.contributor.authorAllanson, Judith
dc.contributor.authorAmrein, Krisztina
dc.contributor.authorAndaluz, Norberto
dc.contributor.authorAzasevac, Antun
dc.contributor.authorAntoni, Anna
dc.contributor.authorArdon, Hilko
dc.contributor.authorAudibert, Gerard
dc.contributor.authorAuslands, Kaspars
dc.contributor.authorAzouvi, Philippe
dc.contributor.authorAzzolini, Luisa
dc.contributor.authorBaciu, Camelia
dc.contributor.authorBadenes, Rafael
dc.contributor.authorBartels, Ronald
dc.contributor.authorBarzo, Pal
dc.contributor.authorBauerfeind, Ursula
dc.contributor.authorBeauvais, Romuald
dc.contributor.authorBeer, Ronny
dc.contributor.authorBelda, Francisco Javier
dc.contributor.authorBellander, Bo Michael
dc.contributor.authorBelli, Antonio
dc.contributor.authorBellier, Remy
dc.contributor.authorBenali, Habib
dc.contributor.authorBenard, Thierry
dc.contributor.authorBerardino, Maurizio
dc.contributor.authorBeretta, Luigi
dc.contributor.authorBeynon, Christopher
dc.contributor.authorBilotta, Federico
dc.contributor.authorBinder, Harald
dc.contributor.authorBiqiri, Erta
dc.date.accessioned2021-04-20T11:53:30Z
dc.date.available2021-04-20T11:53:30Z
dc.date.created2020-09-12T23:10:17Z
dc.date.issued2020
dc.identifier.citationJournal of Neurotrauma. 2020.en_US
dc.identifier.issn0897-7151
dc.identifier.urihttps://hdl.handle.net/11250/2738667
dc.description.abstractRecent biomarker innovations hold potential for transforming diagnosis, prognostic modeling, and precision therapeutic targeting of traumatic brain injury (TBI). However, many biomarkers, including brain imaging, genomics, and proteomics, involve vast quantities of high-throughput and high-content data. Management, curation, analysis, and evidence synthesis of these data are not trivial tasks. In this review, we discuss data management concepts and statistical and data sharing strategies when dealing with biomarker data in the context of TBI research. We propose that application of biomarkers involves three distinct steps—discovery, evaluation, and evidence synthesis. First, complex/big data has to be reduced to useful data elements at the stage of biomarker discovery. Second, inferential statistical approaches must be applied to these biomarker data elements for assessment of biomarker clinical utility and validity. Last, synthesis of relevant research is required to support practice guidelines and enable health decisions informed by the highest quality, up-to-date evidence available. We focus our discussion around recent experiences from the International Traumatic Brain Injury Research (InTBIR) initiative, with a specific focus on four major clinical projects (Transforming Research and Clinical Knowledge in TBI, Collaborative European NeuroTrauma Effectiveness Research in TBI, Collaborative Research on Acute Traumatic Brain Injury in Intensive Care Medicine in Europe, and Approaches and Decisions in Acute Pediatric TBI Trial), which are currently enrolling subjects in North America and Europe. We discuss common data elements, data collection efforts, data-sharing opportunities, and challenges, as well as examine the statistical techniques required to realize successful adoption and use of biomarkers in the clinic as a foundation for precision medicine in TBI.en_US
dc.language.isoengen_US
dc.publisherMary Ann Lieberten_US
dc.titleBiomarkers for Traumatic Brain Injury: Data Standards and Statistical Considerationsen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.source.pagenumber16en_US
dc.source.journalJournal of Neurotraumaen_US
dc.identifier.doi10.1089/neu.2019.6762
dc.identifier.cristin1829379
dc.relation.projectEU/602150en_US
dc.relation.projectNorges forskningsråd: 272789en_US
dc.description.localcodeThis article will not be available due to copyright restrictions (c) 2020 by Mary Ann Liebert, Incen_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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