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dc.contributor.authorBjørgaas, Marit Ragnhild Rokne
dc.contributor.authorFarstad, Hanne
dc.contributor.authorChristiansen, Sverre Christian
dc.contributor.authorBlaas, Harm-Gerd Karl
dc.identifier.citationHormone Research in Paediatrics. 2013, 79 39-43.en_US
dc.description.abstractBackground: Treatment with radioiodine for Graves’ disease regularly increases the level of antithyroid antibodies, and transplacental passage of stimulating thyrotropin receptor antibodies (TRAb) may cause fetal hyperthyroidism. Case presentation: A 21-year-old woman with Graves’ disease received radioiodine treatment to avoid use of antithyroid drugs in pregnancy. She became pregnant 4 months later and was euthyroid during pregnancy. In gestational week (GW) 33, she was admitted with an increased fetal heart rate of 176–180 beats/min. Fetal echocardiography indicated cardiac decompensation. The neonate had severe hyperthyroidism (free thyroxine >100 pmol/l, nv 12.0–22.0), cardiac insufficiency, insufficient weight gain, goiter and considerably accelerated skeletal age. In the mother and neonate, TRAb was >40 IU/l (nv <1.0), indicating transplacental passage of stimulating antibodies. After delivery, TRAb remained >40 IU/l in the woman, and 18 months later she underwent total thyroidectomy with subsequent decline in TRAb. In her next pregnancy, TRAb fluctuated between 38 and 17 IU/l, and repeated fetal ultrasound showed no goiter or sign of hyperthyroidism. In cord blood, TRAb was 10.9 IU/l, and the neonate had normal thyroid hormone levels. Conclusion: This case report illustrates the impact of maternal TRAb level for neonatal outcome in two successive pregnancies.en_US
dc.publisherKarger Publishersen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleImpact of thyrotropin receptor antibody levels on fetal development in two successive pregnancies in a woman with Graves' Diseaseen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.source.journalHormone Research in Paediatricsen_US

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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal