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dc.contributor.authorJiang, Lin
dc.contributor.authorSun, Yi-Qian
dc.contributor.authorLanghammer, Arnulf
dc.contributor.authorBrumpton, Ben Michael
dc.contributor.authorChen, Yu
dc.contributor.authorNilsen, Tom Ivar Lund
dc.contributor.authorLeivseth, Linda
dc.contributor.authorWahl, Sissel Gyrid Freim
dc.contributor.authorMai, Xiao-Mei
dc.identifier.citationScientific Reports. 2021, 11, .en_US
dc.description.abstractLarge prospective studies on asthma, especially asthma symptom control, as a potential risk factor for lung cancer are limited. We followed up 62,791 cancer-free Norwegian adults from 1995–1997 to 2017. Self-reported doctor-diagnosed asthma was categorized into active and non-active asthma. Levels of asthma symptom control were classified into controlled and partially controlled (including partly controlled and uncontrolled) according to the Global Initiative for Asthma guidelines. Incident lung cancer cases were ascertained from the Cancer Registry of Norway. Cox regression models were used to estimate hazard ratios (HRs) with 95% confidence intervals (CIs) for possible associations. Totally, 984 participants developed lung cancer during a median follow-up of 21.1 years. After adjustment for smoking and other potential confounders, an increased incidence of lung cancer was found for adults with partially controlled asthma (HR 1.39, 95% CI 1.00–1.92) compared with those without asthma at baseline. Adults with active asthma had a tendency of increased lung cancer incidence (HR 1.29, 95% CI 0.95–1.75). Sensitivity analyses indicated that the observed associations were less likely resulted from reverse causation or residual confounding by smoking. Our findings suggested that proper control of asthma symptoms might contribute to a reduced incidence of lung cancer.en_US
dc.publisherNature Portfolioen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleAsthma and asthma symptom control in relation to incidence of lung cancer in the HUNT studyen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.source.journalScientific Reportsen_US
dc.relation.projectStiftelsen Dam: 90539400en_US
dc.relation.projectSamarbeidsorganet mellom Helse Midt-Norge og NTNU: 182688-2016en_US
dc.description.localcodeThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit

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