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dc.contributor.authorMølstad, Per
dc.contributor.authorNordrehaug, Jan Erik
dc.contributor.authorSteigen, Terje
dc.contributor.authorMelvær, Giil Lasse
dc.contributor.authorWilsgaard, Tom
dc.contributor.authorWiseth, Rune
dc.contributor.authorBønaa, Kaare Harald
dc.date.accessioned2021-03-30T08:40:41Z
dc.date.available2021-03-30T08:40:41Z
dc.date.created2020-05-16T19:59:13Z
dc.date.issued2020
dc.identifier.citationCardiology. 2020, 145 (6), 333-341.en_US
dc.identifier.issn0008-6312
dc.identifier.urihttps://hdl.handle.net/11250/2736071
dc.description.abstractBackground: The NORSTENT trial randomized 9,013 patients to percutaneous coronary intervention (PCI) with a drug-eluting stent (DES) or bare-metal stent (BMS) with 5-year follow-up. No difference was found in the composite primary outcome of death from any cause and nonfatal spontaneous myocardial infarction after a median of 5 years of follow-up. Secondary outcomes included repeat revascularizations, which were reduced by DES. We report the occurrence of target lesion revascularization (TLR) in time and across demographic and clinical subgroups in patients with lesions in native coronary arteries (n = 8,782). Results: Clinically driven TLR was performed on 488 (5.6%) of the 8,782 patients during 5 years of follow-up. Male gender, older age, visible thrombus in the lesion, and larger stent diameter were associated with less TLR; multivessel disease and longer stents were associated with a higher risk of TLR. There was a substantial and highly significant reduction of the risk of any TLR after 5 years in the DES group (hazard ratio [HR] 0.44, 95% confidence interval [CI] 0.36–0.52], p < 0.001). The effect of DES on TLR was limited in time to the first 2 years in the study with no evidence of a later rebound effect. The reduction in TLR after DES insertion was consistent across subgroups defined by gender, age, diabetes status, renal function, and lesion and stent characteristics. The number needed to treat with DES (vs. BMS) to prevent 1 TLR ranged from 4 to 110 across clinically relevant subgroups. Conclusion: DES have a time-limited effect on the rate of TLR, but with a substantial and highly significant reduction in the first 2 years after the procedure. This effect was found to be consistent across all important clinical subgroups.en_US
dc.language.isoengen_US
dc.publisherKarger Publishersen_US
dc.titleThe effect of drug-eluting stents on target lesion revascularization in native coronary arteries: Results from the NORSTENT randomized studyen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionacceptedVersionen_US
dc.source.pagenumber333-341en_US
dc.source.volume145en_US
dc.source.journalCardiologyen_US
dc.source.issue6en_US
dc.identifier.doi10.1159/000506042
dc.identifier.cristin1811363
dc.description.localcode"This is a post-peer-review, pre-copyedit version of an article. The final authenticated version is available online at: http://dx.doi.org/10.1159/000506042en_US
cristin.ispublishedtrue
cristin.fulltextpostprint
cristin.qualitycode1


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