Blar i Publikasjoner fra CRIStin - NTNU på tittel
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Genetic architecture and heritability of early-life telomere length in a wild passerine
(Peer reviewed; Journal article, 2021)Early-life telomere length (TL) is associated with fitness in a range of organisms. Little is known about the genetic basis of variation in TL in wild animal populations, but to understand the evolutionary and ecological ... -
The genetic architecture of human brainstem structures and their involvement in common brain disorders
(Peer reviewed; Journal article, 2020)Brainstem regions support vital bodily functions, yet their genetic architectures and involvement in common brain disorders remain understudied. Here, using imaging-genetics data from a discovery sample of 27,034 individuals, ... -
The genetic architecture of human brainstem structures and their involvement in common brain disorders
(Peer reviewed; Journal article, 2020)Brainstem regions support vital bodily functions, yet their genetic architectures and involvement in common brain disorders remain understudied. Here, using imaging-genetics data from a discovery sample of 27,034 individuals, ... -
Genetic architecture of subcortical brain structures in 38,851 individuals
(Journal article, 2019)Subcortical brain structures are integral to motion, consciousness, emotions and learning. We identified common genetic variation related to the volumes of the nucleus accumbens, amygdala, brainstem, caudate nucleus, globus ... -
The genetic architecture of the human cerebral cortex
(Peer reviewed; Journal article, 2020)The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, ... -
Genetic assignment of individuals to source populations using network estimation tools
(Peer reviewed; Journal article, 2019)Dispersal, the movement of individuals between populations, is crucial in many ecological and genetic processes. However, direct identification of dispersing individuals is difficult or impossible in natural populations. ... -
Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function
(Peer reviewed; Journal article, 2016)Reduced glomerular filtration rate defines chronic kidney disease and is associated with cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide association studies for estimated glomerular ... -
Genetic associations with temporal shifts in obesity and severe obesity during the obesity epidemic in Norway: A longitudinal population-based cohort (the HUNT Study)
(Peer reviewed; Journal article, 2020)Background Obesity has tripled worldwide since 1975 as environments are becoming more obesogenic. Our study investigates how changes in population weight and obesity over time are associated with genetic predisposition ... -
The genetic background of hydrocephalus in a population-based cohort: implication of ciliary involvement
(Peer reviewed; Journal article, 2023)Hydrocephalus is one of the most common congenital disorders of the central nervous system and often displays psychiatric co-morbidities, in particular autism spectrum disorder. The disease mechanisms behind hydrocephalus ... -
Genetic consequences of conservation action: Restoring the arctic fox (Vulpes lagopus) population in Scandinavia
(Peer reviewed; Journal article, 2020)The Arctic fox (Vulpes lagopus) population in Fennoscandia experienced a drastic bottleneck in the late 19th century as a result of high hunting pressure. In the 1990s, despite nearly 70 years of protection, the population ... -
Genetic control of variability in subcortical and intracranial volumes
(Peer reviewed; Journal article, 2020)Sensitivity to external demands is essential for adaptation to dynamic environments, but comes at the cost of increased risk of adverse outcomes when facing poor environmental conditions. Here, we apply a novel methodology ... -
Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults
(Peer reviewed; Journal article, 2020)Cortical thickness, surface area and volumes vary with age and cognitive function, and in neurological and psychiatric diseases. Here we report heritability, genetic correlations and genome-wide associations of these ... -
Genetic deletion of MMP12 ameliorates cardiometabolic disease by improving insulin sensitivity, systemic inflammation, and atherosclerotic features in mice
(Journal article; Peer reviewed, 2023)Background Matrix metalloproteinase 12 (MMP12) is a macrophage-secreted protein that is massively upregulated as a pro-inflammatory factor in metabolic and vascular tissues of mice and humans suffering from cardiometabolic ... -
Genetic diversity and drug resistance pattern of Mycobacterium tuberculosis strains isolated from pulmonary tuberculosis patients in the Benishangul Gumuz region and its surroundings, Northwest Ethiopia
(Peer reviewed; Journal article, 2020)Introduction Tuberculosis (TB) remains a major global public health problem and is the leading cause of death from a single bacterium, Mycobacterium tuberculosis (MTB) complex. The emergence and spread of drug-resistant ... -
Genetic diversity of rotavirus strains circulating in Norway before and after the introduction of rotavirus vaccination in children
(Peer reviewed; Journal article, 2021)Globally, rotavirus (RV) is the leading cause of acute gastroenteritis (AGE) in young children under 5 years of age. Implementation of RV vaccination is expected to result in fewer cases of RV in the target population, but ... -
Genetic Effects on Longitudinal Changes from Healthy to Adverse Weight and Metabolic Status—The HUNT Study
(Journal article; Peer reviewed, 2015)Introduction: The complexity of obesity and onset and susceptibility of cardio-metabolic disorders are still poorly understood and is addressed here through studies of genetic influence on weight gain and increased ... -
Genetic epidemiology of amyotrophic lateral sclerosis in Norway - a 2-year population based study
(Peer reviewed; Journal article, 2022)Background: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that affects motor neurons. In Europe, disease-causing genetic variants have been identified in 40-70% of familial ALS patients and approximately ... -
Genetic evolution, plasticity, and bet-hedging as adaptive responses to temporally autocorrelated fluctuating selection: A quantitative genetic model
(Journal article; Peer reviewed, 2015)Adaptive responses to autocorrelated environmental fluctuations through evolution in mean reaction norm elevation and slope and an independent component of the phenotypic variance are analyzed using a quantitative genetic ... -
The genetic history of Scandinavia from the Roman Iron Age to the present
(Peer reviewed; Journal article, 2023)We investigate a 2,000-year genetic transect through Scandinavia spanning the Iron Age to the present, based on 48 new and 249 published ancient genomes and genotypes from 16,638 modern individuals. We find regional variation ... -
The genetic impact of an Ebola outbreak on a wild gorilla population
(Peer reviewed; Journal article, 2021)Background Numerous Ebola virus outbreaks have occurred in Equatorial Africa over the past decades. Besides human fatalities, gorillas and chimpanzees have also succumbed to the fatal virus. The 2004 outbreak at the ...