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dc.contributor.authorBjerkli, Inger-Heidi
dc.contributor.authorLaurvik, Helene
dc.contributor.authorNginamau, Elisabeth Sivy
dc.contributor.authorSøland, Tine Merete
dc.contributor.authorCostea, Daniela Elena
dc.contributor.authorHov, Håkon
dc.contributor.authorUhlin-Hansen, Lars
dc.contributor.authorHadler-Olsen, Elin Synnøve
dc.contributor.authorSteigen, Sonja Eriksson
dc.identifier.citationPLOS ONE. 2020, 15:e0239783 (9), 1-13.en_US
dc.description.abstractBackground The majority of oral cavity cancers arise in the oral tongue. The aim of this study was to evaluate the prognostic value of tumor budding in oral tongue squamous cell carcinoma, both as a separate variable and in combination with depth of invasion. We also assessed the prognostic impact of the 8th edition of the American Joint Committee on Cancer’s TNM classification (TNM8), where depth of invasion (DOI) supplements diameter in the tumor size (T) categorization. Methods Patients diagnosed with primary oral tongue squamous cell carcinoma were evaluated retrospectively. Spearman bivariate correlation analyses with bootstrapping were used to identify correlation between variables. Prognostic value of clinical and histopathological variables was assessed by Log rank and Cox regression analyses with bootstrapping using 5-year disease specific survival as outcome. The significance level for the hypothesis test was 0.05. Results One-hundred and fifty patients had available material for microscopic evaluation on Hematoxylin and Eosin-stained slides and were included in the analyses. Reclassification of tumors according to TNM8 caused a shift towards a higher T status compared to the previous classification. The tumor budding score was associated with lymph node metastases where 23% of the patients with low-budding tumors had lymph node metastases, compared with 43% of those with high-budding tumors. T-status, lymph node status, tumor budding, depth of invasion, and the combined tumor budding/depth of invasion score were all significantly associated with survival in univariate analyses. In multivariate analyses only N-status was an independent prognosticator of survival. Conclusion Reclassification according to TNM8 shifted many tumors to a higher T-status, and also increased the prognostic value of the T-status. This supports the implementation of depth of invasion to the T-categorization in TNM8. Tumor budding correlated with lymph node metastases and survival. Therefore, information on tumor budding can aid clinicians in treatment planning and should be included in pathology reports of oral tongue squamous cell carcinomas.en_US
dc.publisherPublic Library of Scienceen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleTumor budding score predicts lymph node status in oral tongue squamous cell carcinoma and should be included in the pathology reporten_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.source.journalPLOS ONEen_US
dc.description.localcodeCopyright: © 2020 Bjerkli et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_US

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