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dc.contributor.authorBjorgan, Asgeir
dc.contributor.authorPukstad, Brita Solveig
dc.contributor.authorRandeberg, Lise Lyngsnes
dc.description.abstractIn vitro wound models are useful for research on wound re‐epithelialization. Hyperspectral imaging represents a non‐destructive alternative to histology analysis for detection of re‐epithelialization. This study aims to characterize the main optical behavior of a wound model in order to enable development of detection algorithms. K‐Means clustering and agglomerative analysis were used to group spatial regions based on the spectral behavior, and an inverse photon transport model was used to explain differences in optical properties. Six samples of the wound model were prepared from human tissue and followed over 22 days. Re‐epithelialization occurred at a mean rate of 0.24 mm2/day after day 8 to 10. Suppression of wound spectral features was the main feature characterizing re‐epithelialized and intact tissue. Modeling the photon transport through a diffuse layer placed on top of wound tissue properties reproduced the spectral behavior. The missing top layer represented by wounds is thus optically detectable using hyperspectral imagingen_US
dc.publisherWiley Online Libraryen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleHyperspectral characterization of re‐epithelialization in an in vitro wound modelen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.source.journalJournal of Biophotonicsen_US
dc.description.localcodeThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. © 2020 The Authors. Journal of Biophotonics published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheimen_US

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Navngivelse 4.0 Internasjonal
Med mindre annet er angitt, så er denne innførselen lisensiert som Navngivelse 4.0 Internasjonal