Does preoperative health-related quality of life predict survival in high-grade glioma patients? – a prospective study
| dc.contributor.author | Haraldseide, Lisa Marie | |
| dc.contributor.author | Jakola, Asgeir S | |
| dc.contributor.author | Solheim, Ole | |
| dc.contributor.author | Sagberg, Lisa Millgård | |
| dc.date.accessioned | 2020-03-20T09:55:42Z | |
| dc.date.available | 2020-03-20T09:55:42Z | |
| dc.date.created | 2020-01-03T21:05:17Z | |
| dc.date.issued | 2019 | |
| dc.identifier.citation | British Journal of Neurosurgery. 2020, 34 (1) | en_US |
| dc.identifier.issn | 0268-8697 | |
| dc.identifier.uri | https://hdl.handle.net/11250/2647748 | |
| dc.description.abstract | Purpose: To explore if preoperative patient-reported health-related quality of life (HRQoL) provides additional prognostic value as a supplement to other preoperatively known clinical factors in patients with high-grade glioma (HGG).Methods: In a prospective explorative study, 114 patients with high-grade glioma were included. The participants completed the generic HRQoL questionnaire EQ-5D 3L, and the disease-specific questionnaires EORTC QLQ-C30 and EORTC QLQ-BN20 1-3 days before surgery. Operating neurosurgeons scored the patient's preoperative functional level by using Karnofsky Performance Status (KPS). Univariate and multivariate Cox regression analyses were performed to identify HRQoL domains that were associated with survival. Kaplan-Meier survival curves and Log-rank tests were used to visualize differences in survival between groups.Results: In addition to preoperative KPS and age, the EORTC QLQ-BN20 subdomains 'seizures' (HR 0.98, p | en_US |
| dc.language.iso | eng | en_US |
| dc.publisher | Informa UK Limited, trading as Taylor & Francis Group. | en_US |
| dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/deed.no | * |
| dc.title | Does preoperative health-related quality of life predict survival in high-grade glioma patients? – a prospective study | en_US |
| dc.type | Peer reviewed | en_US |
| dc.type | Journal article | en_US |
| dc.description.version | publishedVersion | en_US |
| dc.source.pagenumber | 1-7 | en_US |
| dc.source.volume | 34 | en_US |
| dc.source.journal | British Journal of Neurosurgery | en_US |
| dc.source.issue | 1 | en_US |
| dc.identifier.doi | 10.1080/02688697.2019.1698011 | |
| dc.identifier.cristin | 1766148 | |
| dc.description.localcode | © 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way. | en_US |
| cristin.ispublished | true | |
| cristin.fulltext | preprint | |
| cristin.qualitycode | 1 |
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