dc.contributor.author | Nyrønning, Linn Åldstedt | |
dc.contributor.author | Stenman, Malin | |
dc.contributor.author | Hultgren, Rebecka | |
dc.contributor.author | Albrektsen, Grethe | |
dc.contributor.author | Videm, Vibeke | |
dc.contributor.author | Mattsson, Erney | |
dc.date.accessioned | 2020-02-24T10:15:09Z | |
dc.date.available | 2020-02-24T10:15:09Z | |
dc.date.created | 2019-12-02T17:34:59Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | Journal of the American Heart Association. 2019, 8 (21), 1-12. | nb_NO |
dc.identifier.issn | 2047-9980 | |
dc.identifier.uri | http://hdl.handle.net/11250/2643393 | |
dc.description.abstract | Background
Depression is associated with cardiovascular diseases, but the evidence is scarce regarding depression and risk of abdominal aortic aneurysms (AAA). The aim was to determine whether individuals with depressive symptoms have increased risk of AAA.
Methods and Results
This population‐based prospective study included 59 136 participants (52.4% women) aged 50 to 106 years from the HUNT (Norwegian Nord‐Trøndelag Health Study). Symptoms of depression were assessed using the depression subscale of the Hospital Anxiety and Depression Scale (HADS). During a median follow‐up of 13 years, there were 742 incident cases of AAA (201 women). A total of 6401 individuals (12.3%) reported depressive symptoms (defined as HADS depression scale [HADS‐D]) ≥8) (52.5% women). The annual incidence rate of AAA was 1.0 per 1000 individuals. At all ages, the estimated proportion of individuals diagnosed with AAA was higher among those with depressive symptoms (log‐rank test, P<0.001). People with HADS‐D ≥8 were older than those with HADS‐D<8 (median 57.8 versus 52.3 years, P<0.001) and a statistically significantly higher proportion of them (P<0.001) were smokers, overweight or obese, and reported a history of coronary heart disease, diabetes mellitus, and hypertension. In a Cox proportional hazard regression model adjusted for these factors, individuals with depressive symptoms had a ≈30% higher risk of AAA than those without (hazard ratio, 1.32, 95% CI 1.08–1.61, P=0.007).
Conclusions
This study shows that individuals with depressive symptoms have significantly higher risk of incident AAA, after adjustments for established risk factors. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | Wiley Open Access | nb_NO |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/deed.no | * |
dc.title | Symptoms of depression and risk of abdominal aortic aneurysm: A HUNT study | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.description.version | publishedVersion | nb_NO |
dc.source.pagenumber | 1-12 | nb_NO |
dc.source.volume | 8 | nb_NO |
dc.source.journal | Journal of the American Heart Association | nb_NO |
dc.source.issue | 21 | nb_NO |
dc.identifier.doi | 10.1161/JAHA.119.012535 | |
dc.identifier.cristin | 1755687 | |
dc.description.localcode | Copyright © 2019 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. | nb_NO |
cristin.unitcode | 1920,2,0,0 | |
cristin.unitcode | 194,65,25,0 | |
cristin.unitcode | 194,65,20,0 | |
cristin.unitcode | 194,65,15,0 | |
cristin.unitcode | 1920,14,0,0 | |
cristin.unitname | Kirurgisk klinikk | |
cristin.unitname | Institutt for sirkulasjon og bildediagnostikk | |
cristin.unitname | Institutt for samfunnsmedisin og sykepleie | |
cristin.unitname | Institutt for klinisk og molekylær medisin | |
cristin.unitname | Laboratoriemedisinsk klinikk | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |