Glucagon-Like Peptide 1 Receptor Agonists and Risk of Diabetic Retinopathy Complications: Cohort Study in Nationwide Registers From Two Countries
Ueda, Peter; Pasternak, Björn; Eliasson, Björn; Svensson, Ann-Marie; Franzén, Stefan; Gudbjörnsdóttir, Soffia; Hveem, Kristian; Jonasson, Christian; Melbye, Mads; Svanström, Henrik
Journal article, Peer reviewed
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Date
2019Metadata
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- Institutt for samfunnsmedisin og sykepleie [3714]
- Publikasjoner fra CRIStin - NTNU [38672]
- St. Olavs hospital [2581]
Abstract
Post hoc analyses of the Trial to Evaluate Cardiovascular and Other Long-term Outcomes With Semaglutide in Subjects With Type 2 Diabetes (SUSTAIN-6) showed an increased risk of diabetic retinopathy complications associated with semaglutide versus placebo among patients with a history of retinopathy, especially among those with insulin use (1). Although concerns have been raised regarding the safety of glucagon-like peptide 1 (GLP-1) receptor agonists in patients with existing retinopathy, subgroup analyses by retinopathy status at baseline have not been presented for other trials of GLP-1 receptor agonists; the two observational studies on GLP-1 receptor agonists and diabetic retinopathy performed to date have excluded patients with a history of retinopathy (2) or treatment of retinopathy (3).