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dc.contributor.authorØgrim, Kjell Geir
dc.contributor.authorHestad, Knut
dc.contributor.authorBrunner, Jan
dc.contributor.authorKropotov, Yury
dc.date.accessioned2019-10-28T09:42:59Z
dc.date.available2019-10-28T09:42:59Z
dc.date.created2013-11-20T18:35:18Z
dc.date.issued2013
dc.identifier.citationNeuropsychiatric Disease and Treatment. 2013, 9 1301-1309.nb_NO
dc.identifier.issn1176-6328
dc.identifier.urihttp://hdl.handle.net/11250/2624818
dc.description.abstractBackground: The aim of this study was to search for predictors of acute side effects of stimulant medication in pediatric attention deficit/hyperactivity disorder (ADHD), emphasizing variables from quantitative electroencephalography (QEEG), event-related potentials (ERPs), and behavior data from a visual continuous-performance test (VCPT). Methods: Seventy medication-naïve ADHD patients aged 7–16 years were tested with QEEG, including a go/no-go task condition (VCPT) from which behavior data and ERPs were extracted, followed by a systematic trial on stimulant medication lasting at least 4 weeks. Based on data from rating scales and interviews, two psychologists who were blind to the QEEG/ERP test results independently rated the patients as having no or small side effects (n = 37) or troublesome side effects (n = 33). We determined if the side effects were related to sex, age, IQ, ADHD subtype, comorbidities, clinical outcome, and variables in QEEG, ERPs, and VCPT. Results: There was a moderate negative correlation between clinical outcome and side effects. Three variables were significantly associated with side effects in a multivariate logistic regression analysis. In the ERP independent component – contingent negative variation – which reflected action preparation and time evaluation, patients with high amplitudes (close to normal values) experienced more side effects than patients with lower amplitudes. A faster-than-normal reaction time in VCPT was associated with side effects, as was a high amplitude in an early ERP component (early visual independent component), reported to be influenced by attention, perceptual sensitivity, and anxiety. Conclusion: The group with troublesome side effects had normal action-preparation electrical brain activity, a faster-than-normal reaction time, and an increased level of anxiety (measured by ERP) compared with the no side-effects group.nb_NO
dc.language.isoengnb_NO
dc.publisherDove Medical Pressnb_NO
dc.rightsNavngivelse-Ikkekommersiell 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/deed.no*
dc.titlePredicting acute side effects of stimulant medication in pediatric attention deficit/hyperactivity disorder: data from quantitative electroencephalography, event-related potentials, and a continuous-performance testnb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionpublishedVersionnb_NO
dc.source.pagenumber1301-1309nb_NO
dc.source.volume9nb_NO
dc.source.journalNeuropsychiatric Disease and Treatmentnb_NO
dc.identifier.doi10.2147/NDT.S49611
dc.identifier.cristin1067665
dc.description.localcode© 2013 Ogrim et al. This work is published by Dove Medical Press Ltd, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) Licensenb_NO
cristin.unitcode194,67,40,0
cristin.unitcode194,65,30,0
cristin.unitcode1920,5,0,0
cristin.unitnameInstitutt for psykologi
cristin.unitnameInstitutt for nevromedisin og bevegelsesvitenskap
cristin.unitnameKlinikk for fysikalsk medisin og rehabilitering
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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Navngivelse-Ikkekommersiell 4.0 Internasjonal
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