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dc.contributor.authorEsmaeili, Morteza
dc.contributor.authorVettukattil, Riyas M
dc.contributor.authorBathen, Tone Frost
dc.date.accessioned2019-10-25T12:17:42Z
dc.date.available2019-10-25T12:17:42Z
dc.date.created2013-04-12T10:04:35Z
dc.date.issued2013
dc.identifier.citationTranslational Oncology. 2013, 6 (2), 92-98.nb_NO
dc.identifier.issn1944-7124
dc.identifier.urihttp://hdl.handle.net/11250/2624473
dc.description.abstractMutations in the isocitrate dehydrogenase (IDH) genes are frequently found in gliomas and in a fraction of acute myeloid leukemia patients. This results in the production of an oncometabolite, 2-hydroxyglutarate (2-HG). Glioma patients harboring IDH mutations have a longer survival than their wild-type counterparts. 2-HG has been detected noninvasively in gliomas with IDH mutations using magnetic resonance spectroscopy (MRS), suggesting its potential clinical relevance for identifying glioma subtypes with better prognosis. In this paper, the recent developments in the MRS detection of the 2-HG in gliomas are reviewed, including the therapeutic potentials and translational values.nb_NO
dc.language.isoengnb_NO
dc.publisherElseviernb_NO
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/deed.no*
dc.title2-hydroxyglutarate as a magnetic resonance biomarker for glioma subtypingnb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionpublishedVersionnb_NO
dc.source.pagenumber92-98nb_NO
dc.source.volume6nb_NO
dc.source.journalTranslational Oncologynb_NO
dc.source.issue2nb_NO
dc.identifier.doi10.1593/tlo.12424
dc.identifier.cristin1023459
dc.description.localcodeCopyright © 2013 Neoplasia Press, Inc. Open access under CC BY-NC-ND licensenb_NO
cristin.unitcode194,65,25,0
cristin.unitcode1920,0,0,0
cristin.unitnameInstitutt for sirkulasjon og bildediagnostikk
cristin.unitnameSt. Olavs Hospital HF
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal
Med mindre annet er angitt, så er denne innførselen lisensiert som Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal