dc.contributor.author | Esmaeili, Morteza | |
dc.contributor.author | Vettukattil, Riyas M | |
dc.contributor.author | Bathen, Tone Frost | |
dc.date.accessioned | 2019-10-25T12:17:42Z | |
dc.date.available | 2019-10-25T12:17:42Z | |
dc.date.created | 2013-04-12T10:04:35Z | |
dc.date.issued | 2013 | |
dc.identifier.citation | Translational Oncology. 2013, 6 (2), 92-98. | nb_NO |
dc.identifier.issn | 1944-7124 | |
dc.identifier.uri | http://hdl.handle.net/11250/2624473 | |
dc.description.abstract | Mutations in the isocitrate dehydrogenase (IDH) genes are frequently found in gliomas and in a fraction of acute myeloid leukemia patients. This results in the production of an oncometabolite, 2-hydroxyglutarate (2-HG). Glioma patients harboring IDH mutations have a longer survival than their wild-type counterparts. 2-HG has been detected noninvasively in gliomas with IDH mutations using magnetic resonance spectroscopy (MRS), suggesting its potential clinical relevance for identifying glioma subtypes with better prognosis. In this paper, the recent developments in the MRS detection of the 2-HG in gliomas are reviewed, including the therapeutic potentials and translational values. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | Elsevier | nb_NO |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/deed.no | * |
dc.title | 2-hydroxyglutarate as a magnetic resonance biomarker for glioma subtyping | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.description.version | publishedVersion | nb_NO |
dc.source.pagenumber | 92-98 | nb_NO |
dc.source.volume | 6 | nb_NO |
dc.source.journal | Translational Oncology | nb_NO |
dc.source.issue | 2 | nb_NO |
dc.identifier.doi | 10.1593/tlo.12424 | |
dc.identifier.cristin | 1023459 | |
dc.description.localcode | Copyright © 2013 Neoplasia Press, Inc. Open access under CC BY-NC-ND license | nb_NO |
cristin.unitcode | 194,65,25,0 | |
cristin.unitcode | 1920,0,0,0 | |
cristin.unitname | Institutt for sirkulasjon og bildediagnostikk | |
cristin.unitname | St. Olavs Hospital HF | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |