dc.contributor.author | Bakkelund, Karin Elvenes | |
dc.contributor.author | Nordrum, Ivar Skjåk | |
dc.contributor.author | Fossmark, Reidar | |
dc.contributor.author | Waldum, Helge | |
dc.date.accessioned | 2019-10-11T05:48:45Z | |
dc.date.available | 2019-10-11T05:48:45Z | |
dc.date.created | 2012-02-29T23:16:46Z | |
dc.date.issued | 2012 | |
dc.identifier.citation | Gastroenterology Research and Practice. 2012, 457831. | nb_NO |
dc.identifier.issn | 1687-6121 | |
dc.identifier.uri | http://hdl.handle.net/11250/2621477 | |
dc.description.abstract | Objectives. Gastric adenocarcinomas localized to the cardia are increasing. Enterochromaffin-like (ECL) cells play a role in gastric carcinogenesis in hypergastrinemia, and the use of proton pump inhibitors (PPI) leading to hypergastrinemia has increased considerably during the last decades. We have examined cardia cancers for neuroendocrine and ECL cell differentiation. Methods. Thirty-two cardia cancers were examined by immunohistochemical labelling of chromogranin A (CgA), synaptophysin, serotonin, and histidine decarboxylase (HDC). Information about PPI use was collected from the patient records. Results. In 15 of 32 tumours, there were positive signs for one or several neuroendocrine markers. Five cases were CgA and serotonin positive; three of these carcinomas were also positive for HDC. Three patients were long-term users of PPI, and two of these were immunoreactive for neuroendocrine markers. Conclusions. A high proportion of cardia cancers expressed neuroendocrine markers, but only few patients with cardia cancers were using PPI. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | Hindawi | nb_NO |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Gastric Carcinomas Localized to the Cardia | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.description.version | publishedVersion | nb_NO |
dc.source.pagenumber | 6 | nb_NO |
dc.source.journal | Gastroenterology Research and Practice | nb_NO |
dc.identifier.doi | 10.1155/2012/457831 | |
dc.identifier.cristin | 912864 | |
dc.description.localcode | Copyright © 2012 Karin E. Bakkelund et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | nb_NO |
cristin.unitcode | 194,65,15,0 | |
cristin.unitcode | 1920,14,0,0 | |
cristin.unitcode | 1920,15,0,0 | |
cristin.unitname | Institutt for klinisk og molekylær medisin | |
cristin.unitname | Laboratoriemedisinsk klinikk | |
cristin.unitname | Medisinsk klinikk | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |