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dc.contributor.authorBakkelund, Karin Elvenes
dc.contributor.authorNordrum, Ivar Skjåk
dc.contributor.authorFossmark, Reidar
dc.contributor.authorWaldum, Helge
dc.date.accessioned2019-10-11T05:48:45Z
dc.date.available2019-10-11T05:48:45Z
dc.date.created2012-02-29T23:16:46Z
dc.date.issued2012
dc.identifier.citationGastroenterology Research and Practice. 2012, 457831.nb_NO
dc.identifier.issn1687-6121
dc.identifier.urihttp://hdl.handle.net/11250/2621477
dc.description.abstractObjectives. Gastric adenocarcinomas localized to the cardia are increasing. Enterochromaffin-like (ECL) cells play a role in gastric carcinogenesis in hypergastrinemia, and the use of proton pump inhibitors (PPI) leading to hypergastrinemia has increased considerably during the last decades. We have examined cardia cancers for neuroendocrine and ECL cell differentiation. Methods. Thirty-two cardia cancers were examined by immunohistochemical labelling of chromogranin A (CgA), synaptophysin, serotonin, and histidine decarboxylase (HDC). Information about PPI use was collected from the patient records. Results. In 15 of 32 tumours, there were positive signs for one or several neuroendocrine markers. Five cases were CgA and serotonin positive; three of these carcinomas were also positive for HDC. Three patients were long-term users of PPI, and two of these were immunoreactive for neuroendocrine markers. Conclusions. A high proportion of cardia cancers expressed neuroendocrine markers, but only few patients with cardia cancers were using PPI.nb_NO
dc.language.isoengnb_NO
dc.publisherHindawinb_NO
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleGastric Carcinomas Localized to the Cardianb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionpublishedVersionnb_NO
dc.source.pagenumber6nb_NO
dc.source.journalGastroenterology Research and Practicenb_NO
dc.identifier.doi10.1155/2012/457831
dc.identifier.cristin912864
dc.description.localcodeCopyright © 2012 Karin E. Bakkelund et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.nb_NO
cristin.unitcode194,65,15,0
cristin.unitcode1920,14,0,0
cristin.unitcode1920,15,0,0
cristin.unitnameInstitutt for klinisk og molekylær medisin
cristin.unitnameLaboratoriemedisinsk klinikk
cristin.unitnameMedisinsk klinikk
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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