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dc.contributor.authorÅm, Marte Kierulf
dc.contributor.authorFougner, Anders Lyngvi
dc.contributor.authorEllingsen, Reinold
dc.contributor.authorHjelme, Dag Roar
dc.contributor.authorBösch, Patrick Christian
dc.contributor.authorStavdahl, Øyvind
dc.contributor.authorCarlsen, Sven Magnus
dc.contributor.authorChristiansen, Sverre
dc.date.accessioned2019-09-04T06:49:43Z
dc.date.available2019-09-04T06:49:43Z
dc.date.created2019-07-30T09:27:56Z
dc.date.issued2019
dc.identifier.citationMedical Hypotheses. 2019, 132 (109318)nb_NO
dc.identifier.issn0306-9877
dc.identifier.urihttp://hdl.handle.net/11250/2612345
dc.description.abstractThe artificial pancreas requires fast and reliable glucose measurements. The peritoneal space has shown promising results, and in one of our studies we detected glucose changes in the peritoneal space already at the same time as in the femoral artery. The peritoneal lining is highly vascularised, covered by a single layer of mesothelial cells and therefore easily accessible for proper sensor technology, e.g. optical technology. We hypothesize that the rapid intraperitoneal glucose dynamics observed in our study was possible because the sensors were located directly at the peritoneal lining, at the point where the glucose molecules entered the peritoneal space. Glucose travels slowly in fluids by diffusion, and a longer distance between the sensor and the peritoneal lining would consequently result in slower dynamics. We therefore propose to place the glucose sensor in an artificial pancreas as closely to the peritoneal lining as possible, or even utilize appropriate sensor technology to measure glucose in the peritoneal lining itself.nb_NO
dc.language.isoengnb_NO
dc.publisherElseviernb_NO
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/deed.no*
dc.subjectType 1 diabetesnb_NO
dc.subjectKontinuerlig glukosemålingnb_NO
dc.subjectContinuous glucose measurementnb_NO
dc.subjectGlukosemålingnb_NO
dc.subjectGlucose sensingnb_NO
dc.subjectPeritoneumnb_NO
dc.titleWhy intraperitoneal glucose sensing is sometimes surprisingly rapid and sometimes slow: A hypothesisnb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionacceptedVersionnb_NO
dc.subject.nsiVDP::Medisinsk teknologi: 620nb_NO
dc.subject.nsiVDP::Medical technology: 620nb_NO
dc.source.volume132nb_NO
dc.source.journalMedical Hypothesesnb_NO
dc.identifier.doi10.1016/j.mehy.2019.109318
dc.identifier.cristin1713136
dc.relation.projectNorges forskningsråd: 248872nb_NO
dc.description.localcode© 2019. This is the authors’ accepted and refereed manuscript to the article. Locked until 20 July 2020 due to copyright restrictions. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/nb_NO
cristin.unitcode1920,15,0,0
cristin.unitcode194,65,15,0
cristin.unitcode194,63,25,0
cristin.unitcode194,63,35,0
cristin.unitnameMedisinsk klinikk
cristin.unitnameInstitutt for klinisk og molekylær medisin
cristin.unitnameInstitutt for teknisk kybernetikk
cristin.unitnameInstitutt for elektroniske systemer
cristin.ispublishedfalse
cristin.fulltextpreprint
cristin.fulltextpostprint
cristin.fulltextoriginal
cristin.qualitycode1


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Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal
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