• Chemical, Physical and Biological Triggers of Evolutionary Sonserved Bcl-xL-Mediated Apoptosis 

      Ianevski, Aleksandr; Kulesskiy, Evgeny; Krpina, Klara; Lou, Guofeng; Aman, Yahyah; Bugai, Andrii; Aasumets, Koit; Akimov, Yevhen; Bulanova, Daria; Gildemann, Kiira; Arutyunyan, Albert F.; Susova, Olga Yu.; Zhuze, Alexei L.; Ji, Ping; Wang, Wei; Holien, Toril; Bugge, Marit; Zusinaite, Eva; Oksenych, Valentyn; Lysvand, Hilde; Gerhold, Joachim M.; Bjørås, Magnar; Johansen, Pål; Waage, Anders; Heckman, Caroline A.; Fang, Evandro Fei; Kainov, Denis (Journal article; Peer reviewed, 2020)
      Background: The evidence that pan-Bcl-2 or Bcl-xL-specific inhibitors prematurely kill virus-infected or RNA/DNA-transfected cells provides rationale for investigating these apoptotic inducers further. We hypothesized that ...
    • Gastric Cancers Missed at Upper Endoscopy in Central Norway 2007 to 2016—a Population-Based Study 

      Beck, Marianne; Bringeland, Erling A.; Qvigstad, Gunnar; Fossmark, Reidar (Peer reviewed; Journal article, 2021)
      Simple summary: Stomach cancer may be missed during upper endoscopy. We have examined how often this occurs and identified factors associated with missed cancers. Among 730 patients with gastric cancer, 67 (9.2%) were ...
    • Glioblastoma Surgery Imaging-Reporting and Data System: Validation and Performance of the Automated Segmentation Task 

      Bouget, David Nicolas Jean-Marie; Eijgelaar, Roelant; Pedersen, André; Kommers, Ivar; Ardon, Hilko; Barkhof, Frederik; Bello, Lorenzo; Berger, Mitchel S.; Nibali, Marco Conti; Furtner, Julia; Fyllingen, Even Hovig; Hervey-Jumper, Shawn; Idema, Albert J. S.; Kiesel, Barbara; Kloet, Alfred; Mandonnet, Emmanuel; Müller, Domenique M. J.; Robe, Pierre; Rossi, Marco; Sagberg, Lisa Millgård; Sciortino, Tommaso; van den Brink, Wimar A.; Wagemakers, Michiel; Widhalm, Georg; Witte, Marnix G.; Zwinderman, Aeilko H.; Reinertsen, Ingerid; Hamer, Philip C De Witt; Solheim, Ole (Journal article; Peer reviewed, 2021)
      For patients with presumed glioblastoma, essential tumor characteristics are determined from preoperative MR images to optimize the treatment strategy. This procedure is time-consuming and subjective, if performed by crude ...
    • Glioblastoma Surgery Imaging—Reporting and Data System: Standardized Reporting of Tumor Volume, Location, and Resectability Based on Automated Segmentations 

      Kommers, Ivar; Bouget, David Nicolas Jean-Marie; Pedersen, André; Eijgelaar, Roelant; Ardon, Hilko; Barkhof, Frederik; Bello, Lorenzo; Berger, Mitchel S.; Nibali, Marco Conti; Furtner, Julia; Fyllingen, Even Hovig; Hervey-Jumper, Shawn; Idema, Albert J. S.; Kiesel, Barbara; Kloet, Alfred; Mandonnet, Emmanuel; Müller, Domenique M. J.; Robe, Pierre; Rossi, Marco; Sagberg, Lisa Millgård; Sciortino, Tommaso; van den Brink, Wimar A.; Wagemakers, Michiel; Widhalm, Georg; Witte, Marnix G.; Zwinderman, Aeilko H.; Reinertsen, Ingerid; Solheim, Ole; De Witt Hamer, Philip C. (Peer reviewed; Journal article, 2021)
      Treatment decisions for patients with presumed glioblastoma are based on tumor characteristics available from a preoperative MR scan. Tumor characteristics, including volume, location, and resectability, are often estimated ...
    • Liquid Biopsies in Solid Cancers: Implementation in a Nordic Healthcare System 

      Nordgård, Oddmund; Forthun, Rakel Brendsdal; Lapin, Morten; Grønberg, Bjørn Henning; Kalland, Karl Henning; Kopperud, Reidun Kristin; Thomsen, Liv Cecilie Vestrheim; Tjensvoll, Kjersti; Gilje, Bjørnar; Gjertsen, Bjørn Tore; Hovland, Randi (Peer reviewed; Journal article, 2021)
      Liquid biopsies have emerged as a potential new diagnostic tool, providing detailed information relevant for characterization and treatment of solid cancers. We here present an overview of current evidence supporting the ...
    • Nephronectin as a matrix effector in cancer 

      Norvoll Magnussen, Synnøve; Toraskar, Jimita Prashant; Hadler-Olsen, Elin Synnøve; Steigedal, Tonje S.; Svineng, Gunbjørg (Peer reviewed; Journal article, 2021)
      The extracellular matrix protein nephronectin plays an important regulatory role during embryonic development, controlling renal organogenesis through integrin α8β1 association. Nephronectin has three main domains: five ...
    • The prognostic effect of KRAS mutations in non-small cell lung carcinoma revisited: A norwegian multicentre study 

      Wahl, Sissel Gyrid Freim; Hong, Yan Dai; Emdal, Elisabeth Fritzke; Berg, Thomas; Halvorsen, Tarje Onsøien; Ottestad, Anine Larsen; Lund-Iversen, Marius; Brustugun, Odd; Førde, Dagny; Paulsen, Erna-Elise; Donnem, Tom; Andersen, Sigve; Grønberg, Bjørn Henning; Richardsen, Elin (Peer reviewed; Journal article, 2021)
      Background: due to emerging therapeutics targeting KRAS G12C and previous reports with conflicting results regarding the prognostic impact of KRAS and KRAS G12C in non-small cell lung cancer (NSCLC), we aimed to investigate ...
    • The prognostic value of methylation signatures and NF2 mutations in atypical meningiomas 

      Meta, Rahmina; Boldt, Henning B.; Kristensen, Bjarne W.; Sahm, Felix; Sjursen, Wenche; Torp, Sverre Helge (Peer reviewed; Journal article, 2021)
      Background: Due to the solely subjective histopathological assessment, the WHO 2016 classification of human meningiomas is subject to interobserver variation. Consequently, the need for more reliable and objective markers ...
    • Quality of life in vulnerable older patients with metastatic colorectal cancer receiving palliative chemotherapy—the randomized nordic9-study 

      Liposits, Gabor; Eshoj, Henrik; Möller, Sören; Winther, Stine Brændegaard; Skuladottir, Halla; Ryg, Jesper; Hofsli, Eva; Shah, Carl-Henrik; Poulsen, Laurids Østergaard; Berglund, Åke; Qvortrup, Camilla; Österlund, Pia; Glimelius, Bengt; Sorbye, Halfdan; Pfeiffer, Per (Peer reviewed; Journal article, 2021)
      Bowel cancer is one of the leading cancer-types in both sexes worldwide. Despite that most new cases and deaths occur in people aged 70 years or older, few clinical trials have investigated the best way to administer ...
    • Selective Killing of Activated T Cells by 5-Aminolevulinic Acid Mediated Photodynamic Effect: Potential Improvement of Extracorporeal Photopheresis 

      Darvekar, Sagar; Juzenas, Petras; Oksvold, Morten Pedersen; Kleinauskas, Andrius; Holien, Toril; Christensen, Eidi; Stokke, Trond; Sioud, Mouldy; Qian, Peng (Peer reviewed; Journal article, 2020)
      Extracorporeal photopheresis (ECP), a modality that exposes isolated leukocytes to the photosensitizer 8-methoxypsoralen (8-MOP) and ultraviolet-A (UV-A) light, is used to treat conditions such as cutaneous T-cell lymphoma ...
    • Survival and disease recurrence in patients with duodenal neuroendocrine tumours—a single centre cohort 

      Folkestad, Oddry; Wasmuth, Hans; Mjønes, Patricia; Fougner, Reidun; Hauso, Øyvind; Fossmark, Reidar (Journal article; Peer reviewed, 2021)
      Background: Duodenal neuroendocrine tumours (D-NETs) are rare but increasingly diagnosed. This study aimed to assess the overall survival and recurrence rate among patients treated for D-NETs. Methods: Patients with D-NETs ...