• Antibiotic Therapy in Integrated Oncology and Palliative Cancer Care: An Observational Study 

      Moen, Martine Kjølberg; Løhre, Erik T; Jakobsen, Gunnhild; Thronæs, Morten; Klepstad, Pål (Peer reviewed; Journal article, 2022)
      Simple Summary Approximately one-quarter of the patients with advanced cancer acutely admitted to the Palliative Care Unit at St. Olav’s University Hospital received intravenous antibiotics. We observed that physiological ...
    • Central Pathology Review in SENTIX, A Prospective Observational International Study on Sentinel Lymph Node Biopsy in Patients with Early-Stage Cervical Cancer (ENGOT-CX2) 

      Nemejcova, Kristyna; Kocian, Roman; Kohler, Christhardt; Jarkovsky, Jiri; Klat, Jaroslav; Berjon, Alberto; Pilka, Radovan; Sehnal, Borek; Gil-Ibanez, Blanca; Lupo, Ezequiel; Petiz, Almerinda; Sanchez, Octavio Arencibia; Kascak, Peter; Martinelli, Fabio; Buda, Alessandro; Presl, Jiri; Barahona, Marc; van Lonkhuijzen, Luc; Szatkowski, Wiktor; Minar, Lubos; Pakiz, Maja; Havelka, Pavel; Zorrero, Christina; Misiek, Marcin; Snyman, Leon Cornelius; Wydra, Dariusz; Vergote, Ignace; Vinnytska, Alla; Redecha, Mikulas; Michal, Martin; Tingulstad, Solveig Kristi; Kipp, Barbara; Szewczyk, Grzegorz; Toth, Robert; de Santiago Garcia, Francisco Javier; Coronado Martin, Pluvio Jesus; Poka, Robert; Tamussino, Karl; Luyckx, Mathieu; Fastrez, Maxime; Staringer, Juan Carlos; Germanova, Anna; Plaikner, Andrea; Bajsova, Sylva; Dundr, Pavel; Mallmann-Gottschalk, Nina; Cibula, David (Peer reviewed; Journal article, 2020)
      The quality of pathological assessment is crucial for the safety of patients with cervical cancer if pelvic lymph node dissection is to be replaced by sentinel lymph node (SLN) biopsy. Central pathology review of SLN ...
    • Chemical, Physical and Biological Triggers of Evolutionary Sonserved Bcl-xL-Mediated Apoptosis 

      Ianevski, Aleksandr; Kulesskiy, Evgeny; Krpina, Klara; Lou, Guofeng; Aman, Yahyah; Bugai, Andrii; Aasumets, Koit; Akimov, Yevhen; Bulanova, Daria; Gildemann, Kiira; Arutyunyan, Albert F.; Susova, Olga Yu.; Zhuze, Alexei L.; Ji, Ping; Wang, Wei; Holien, Toril; Bugge, Marit; Zusinaite, Eva; Oksenych, Valentyn; Lysvand, Hilde; Gerhold, Joachim M.; Bjørås, Magnar; Johansen, Pål; Waage, Anders; Heckman, Caroline A.; Fang, Evandro Fei; Kainov, Denis (Journal article; Peer reviewed, 2020)
      Background: The evidence that pan-Bcl-2 or Bcl-xL-specific inhibitors prematurely kill virus-infected or RNA/DNA-transfected cells provides rationale for investigating these apoptotic inducers further. We hypothesized that ...
    • A Comparative Analysis of Orthotopic and Subcutaneous Pancreatic Tumour Models: Tumour Microenvironment and Drug Delivery 

      Lage Fernandez, Jessica; Årbogen, Sara Beate Stjern; Sadeghinia, Mohammadjavad; Haram, Karin Margrete; Snipstad, Sofie; Torp, Sverre Helge; Einen, Caroline; Mühlenpfordt, Melina; Maardalen, Matilde; Vikedal, Krister; Davies, Catharina de Lange (Peer reviewed; Journal article, 2023)
      Pancreatic ductal adenocarcinoma (PDAC) remains a challenging malignancy, mainly due to its resistance to chemotherapy and its complex tumour microenvironment characterised by stromal desmoplasia. There is a need for new ...
    • Gastric Cancers Missed at Upper Endoscopy in Central Norway 2007 to 2016—a Population-Based Study 

      Beck, Marianne; Bringeland, Erling A.; Qvigstad, Gunnar; Fossmark, Reidar (Peer reviewed; Journal article, 2021)
      Simple summary: Stomach cancer may be missed during upper endoscopy. We have examined how often this occurs and identified factors associated with missed cancers. Among 730 patients with gastric cancer, 67 (9.2%) were ...
    • Glioblastoma Surgery Imaging-Reporting and Data System: Validation and Performance of the Automated Segmentation Task 

      Bouget, David Nicolas Jean-Marie; Eijgelaar, Roelant; Pedersen, André; Kommers, Ivar; Ardon, Hilko; Barkhof, Frederik; Bello, Lorenzo; Berger, Mitchel S.; Nibali, Marco Conti; Furtner, Julia; Fyllingen, Even Hovig; Hervey-Jumper, Shawn; Idema, Albert J. S.; Kiesel, Barbara; Kloet, Alfred; Mandonnet, Emmanuel; Müller, Domenique M. J.; Robe, Pierre; Rossi, Marco; Sagberg, Lisa Millgård; Sciortino, Tommaso; van den Brink, Wimar A.; Wagemakers, Michiel; Widhalm, Georg; Witte, Marnix G.; Zwinderman, Aeilko H.; Reinertsen, Ingerid; Hamer, Philip C De Witt; Solheim, Ole (Journal article; Peer reviewed, 2021)
      For patients with presumed glioblastoma, essential tumor characteristics are determined from preoperative MR images to optimize the treatment strategy. This procedure is time-consuming and subjective, if performed by crude ...
    • Glioblastoma Surgery Imaging—Reporting and Data System: Standardized Reporting of Tumor Volume, Location, and Resectability Based on Automated Segmentations 

      Kommers, Ivar; Bouget, David Nicolas Jean-Marie; Pedersen, André; Eijgelaar, Roelant; Ardon, Hilko; Barkhof, Frederik; Bello, Lorenzo; Berger, Mitchel S.; Nibali, Marco Conti; Furtner, Julia; Fyllingen, Even Hovig; Hervey-Jumper, Shawn; Idema, Albert J. S.; Kiesel, Barbara; Kloet, Alfred; Mandonnet, Emmanuel; Müller, Domenique M. J.; Robe, Pierre; Rossi, Marco; Sagberg, Lisa Millgård; Sciortino, Tommaso; van den Brink, Wimar A.; Wagemakers, Michiel; Widhalm, Georg; Witte, Marnix G.; Zwinderman, Aeilko H.; Reinertsen, Ingerid; Solheim, Ole; De Witt Hamer, Philip C. (Peer reviewed; Journal article, 2021)
      Treatment decisions for patients with presumed glioblastoma are based on tumor characteristics available from a preoperative MR scan. Tumor characteristics, including volume, location, and resectability, are often estimated ...
    • International e-Delphi Consensus Recommendations for the Assessment and Diagnosis of Circadian rest–Activity Rhythm Disorders (CARDs) in Patients with Cancer 

      Gouldthorpe, Craig; Ancoli-Israel, Sonia; Cash, Elizabeth; Innominato, Pasquale; Jakobsen, Gunnhild; Lévi, Francis; Miaskowski, Christine; Parganiha, Arti; Pati, Atanu Kumar; Pereira, Deidre; Revell, Victoria; Zeitzer, Jamie M.; Davies, Andrew (Peer reviewed; Journal article, 2023)
      Purpose: Circadian rest–Activity Rhythm Disorders (CARDs) are common in patients with cancer, particularly in advanced disease. CARDs are associated with increased symptom burden, poorer quality of life, and shorter survival. ...
    • Liquid Biopsies in Solid Cancers: Implementation in a Nordic Healthcare System 

      Nordgård, Oddmund; Forthun, Rakel Brendsdal; Lapin, Morten; Grønberg, Bjørn Henning; Kalland, Karl Henning; Kopperud, Reidun Kristin; Thomsen, Liv Cecilie Vestrheim; Tjensvoll, Kjersti; Gilje, Bjørnar; Gjertsen, Bjørn Tore; Hovland, Randi (Peer reviewed; Journal article, 2021)
      Liquid biopsies have emerged as a potential new diagnostic tool, providing detailed information relevant for characterization and treatment of solid cancers. We here present an overview of current evidence supporting the ...
    • Lower-Limb Lymphedema after Sentinel Lymph Node Biopsy in Cervical Cancer Patients 

      Cibula, David; Borcinova, Martina; Marnitz, Simone; Jarkovsky, Jiri; Klat, Jaroslav; Pilka, Radovan; Torne, Aureli; Zapardiel, Ignacio; Petiz, Almerinda; Lay, Laura; Sehnal, Borek; Ponce, Jordi; Felsinger, Michal; Arencibia-Sánchez, Octavio; Kascak, Peter; Zalewski, Kamil; Presl, Jiri; Palop-Moscardo, Alicia; Tingulstad, Solveig Kristi; Vergote, Ignace; Redecha, Mikulas; Fruhauf, Filip; Kohler, Christhardt; Kocian, Roman (Peer reviewed; Journal article, 2021)
      Background: To prospectively assess LLL incidence among cervical cancer patients treated by uterine surgery complemented by SLN biopsy, without PLND. Methods: A prospective study in 150 patients with stage IA1–IB2 cervical ...
    • Nephronectin as a matrix effector in cancer 

      Norvoll Magnussen, Synnøve; Toraskar, Jimita Prashant; Hadler-Olsen, Elin Synnøve; Steigedal, Tonje S.; Svineng, Gunbjørg (Peer reviewed; Journal article, 2021)
      The extracellular matrix protein nephronectin plays an important regulatory role during embryonic development, controlling renal organogenesis through integrin α8β1 association. Nephronectin has three main domains: five ...
    • Predicting Regions of Local Recurrence in Glioblastomas Using Voxel-Based Radiomic Features of Multiparametric Postoperative MRI 

      Cepeda, Santiago; Luppino, Luigi Tommaso; Pérez-Núñez, Angel; Solheim, Ole Skeidsvoll; García-García, Sergio; Velasco-Casares, María; Karlberg, Anna Maria; Eikenes, Live; Sarabia, Rosario; Arrese, Ignacio; Zamora, Tomás; Gonzalez, Pedro; Jiménez-Roldán, Luis; Kuttner, Samuel (Peer reviewed; Journal article, 2023)
      The globally accepted surgical strategy in glioblastomas is removing the enhancing tumor. However, the peritumoral region harbors infiltration areas responsible for future tumor recurrence. This study aimed to evaluate a ...
    • Preoperative Prognostic Index for Patients with Brain Metastases—A Population-Based Multi-Centre Study 

      Winther, Rebecca Rootwelt; Skovlund, Eva; Andreassen, Joakim Stray; Arvidsson, Lisa; Halvardson, Jonathan; Solheim, Ole Skeidsvoll; Bartek, Jiri; Kaasa, Stein; Hjermstad, Marianne Jensen; Vik-Mo, Einar Osland (Peer reviewed; Journal article, 2023)
      Background: Brain metastases (BM) are common in cancer patients and are associated with high morbidity and mortality. Surgery is an option, but the optimal selection of patients for surgery is challenging and controversial. ...
    • The prognostic effect of KRAS mutations in non-small cell lung carcinoma revisited: A norwegian multicentre study 

      Wahl, Sissel Gyrid Freim; Hong, Yan Dai; Emdal, Elisabeth Fritzke; Berg, Thomas; Halvorsen, Tarje Onsøien; Ottestad, Anine Larsen; Lund-Iversen, Marius; Brustugun, Odd; Førde, Dagny; Paulsen, Erna-Elise; Donnem, Tom; Andersen, Sigve; Grønberg, Bjørn Henning; Richardsen, Elin (Peer reviewed; Journal article, 2021)
      Background: due to emerging therapeutics targeting KRAS G12C and previous reports with conflicting results regarding the prognostic impact of KRAS and KRAS G12C in non-small cell lung cancer (NSCLC), we aimed to investigate ...
    • The prognostic value of methylation signatures and NF2 mutations in atypical meningiomas 

      Meta, Rahmina; Boldt, Henning B.; Kristensen, Bjarne W.; Sahm, Felix; Sjursen, Wenche; Torp, Sverre Helge (Peer reviewed; Journal article, 2021)
      Background: Due to the solely subjective histopathological assessment, the WHO 2016 classification of human meningiomas is subject to interobserver variation. Consequently, the need for more reliable and objective markers ...
    • Quality of life in vulnerable older patients with metastatic colorectal cancer receiving palliative chemotherapy—the randomized nordic9-study 

      Liposits, Gabor; Eshoj, Henrik; Möller, Sören; Winther, Stine Brændegaard; Skuladottir, Halla; Ryg, Jesper; Hofsli, Eva; Shah, Carl-Henrik; Poulsen, Laurids Østergaard; Berglund, Åke; Qvortrup, Camilla; Österlund, Pia; Glimelius, Bengt; Sorbye, Halfdan; Pfeiffer, Per (Peer reviewed; Journal article, 2021)
      Bowel cancer is one of the leading cancer-types in both sexes worldwide. Despite that most new cases and deaths occur in people aged 70 years or older, few clinical trials have investigated the best way to administer ...
    • Response Evaluation after Neoadjuvant Chemotherapy for Resectable Gastric Cancer 

      Sandø-Klemmetvoll, Alina Desiree; Fougner, Reidun; Røyset, Elin Synnøve; Dai, Hong Yan; Grønbech, Jon Erik; Bringeland, Erling Audun (Peer reviewed; Journal article, 2023)
      Background: The method of response evaluation following neoadjuvant chemotherapy (NAC) in resectable gastric cancer has been widely debated. An essential prerequisite is the ability to stratify patients into subsets of ...
    • Selective Killing of Activated T Cells by 5-Aminolevulinic Acid Mediated Photodynamic Effect: Potential Improvement of Extracorporeal Photopheresis 

      Darvekar, Sagar; Juzenas, Petras; Oksvold, Morten Pedersen; Kleinauskas, Andrius; Holien, Toril; Christensen, Eidi; Stokke, Trond; Sioud, Mouldy; Qian, Peng (Peer reviewed; Journal article, 2020)
      Extracorporeal photopheresis (ECP), a modality that exposes isolated leukocytes to the photosensitizer 8-methoxypsoralen (8-MOP) and ultraviolet-A (UV-A) light, is used to treat conditions such as cutaneous T-cell lymphoma ...
    • Survival and disease recurrence in patients with duodenal neuroendocrine tumours—a single centre cohort 

      Folkestad, Oddry; Wasmuth, Hans; Mjønes, Patricia; Fougner, Reidun; Hauso, Øyvind; Fossmark, Reidar (Journal article; Peer reviewed, 2021)
      Background: Duodenal neuroendocrine tumours (D-NETs) are rare but increasingly diagnosed. This study aimed to assess the overall survival and recurrence rate among patients treated for D-NETs. Methods: Patients with D-NETs ...
    • Survival Trends in Patients with Small Intestinal Neuroendocrine Tumours—A Cohort Study in Central Norway 

      Folkestad, Oddry H; Hauso, Øyvind; Mjønes, Patricia Gjertrud; Fougner, Reidun; Wasmuth, Hans; Fossmark, Reidar (Peer reviewed; Journal article, 2023)
      Improved surgical resection and oncological treatment, or an earlier diagnosis may increase survival in small intestinal neuroendocrine tumours (SI-NETs), but only few studies have examined survival trends. We aimed to ...