Now showing items 1-20 of 488

    • 1-year follow-up of 920 hip and knee arthroplasty patients after implementing fast-track: Good outcomes in a Norwegian university hospital 

      Winther, Siri Bjørgen; Foss, Olav A.; Wik, Tina Strømdal; Davis, Shawn Patric; Engdal, Monika; Jessen, Vigleik; Husby, Otto Schnell (Journal article; Peer reviewed, 2015)
      Background — Fast–track has become a well–known concept resulting in improved patient satisfaction and postoperative results. Concerns have been raised about whether increased efficiency could compromise safety, and whether ...
    • 18F-FACBC PET/MRI in diagnostic assessment and neurosurgery of gliomas 

      Karlberg, Anna Maria; Berntsen, Erik Magnus; Johansen, Håkon; Skjulsvik, Anne Jarstein; Reinertsen, Ingerid; Hong, Yan Dai; Xiao, Yiming; Rivaz, Hassan; Borghammer, Per; Solheim, Ole; Eikenes, Live (Journal article; Peer reviewed, 2019)
      Purpose This pilot study aimed to evaluate the amino acid tracer 18F-FACBC with simultaneous PET/MRI in diagnostic assessment and neurosurgery of gliomas. Materials and Methods Eleven patients with suspected primary or ...
    • 2-hydroxyglutarate as a magnetic resonance biomarker for glioma subtyping 

      Esmaeili, Morteza; Vettukattil, Riyas M; Bathen, Tone Frost (Journal article; Peer reviewed, 2013)
      Mutations in the isocitrate dehydrogenase (IDH) genes are frequently found in gliomas and in a fraction of acute myeloid leukemia patients. This results in the production of an oncometabolite, 2-hydroxyglutarate (2-HG). ...
    • A 36-month follow-up of decline in activities of daily living in individuals receiving domiciliary care 

      Helvik, Anne-Sofie; Høgset, Lisbeth Dyrendal; Bergh, Sverre; Saltyte Benth, Jurate; Kirkevold, Øyvind; Selbæk, Geir (Journal article; Peer reviewed, 2015)
      Background There have been few studies of how personal and instrumental activities of daily living (P-ADL and I-ADL) develop over time in older people receiving domiciliary care. This study aimed at assessing variables ...
    • A balanced tissue composition reveals new metabolic and gene expression markers in prostate cancer 

      Tessem, May-Britt; Bertilsson, Helena; Angelsen, Anders; Bathen, Tone Frost; Drabløs, Finn Sverre; Rye, Morten Beck (Journal article; Peer reviewed, 2016)
      Molecular analysis of patient tissue samples is essential to characterize the in vivo variability in human cancers which are not accessible in cell-lines or animal models. This applies particularly to studies of tumor ...
    • A European multicentre evaluation of detection and typing methods for human enteroviruses and parechoviruses using RNA transcripts 

      Hayes, A; Nguyen, Dung; Andersson, Monique; Antón, Andres; Bailly, Jean-Luc; Beard, Stuart; Benschop, Kimberley; Berginc, Natasa; Blomqvist, Soile; Cunningham, Emma; Davis, D; Dembinski, Jennifer Lynn; Diedrich, Sabine; Dudman, Susanne Marie Rogne Gjeruldsen; Dyrdak, R; Eltringham, G. J. A.; Gonzales-Goggia, S; Gunson, R; Howson-Wells, H. C.; Jääskeläinen, A. J.; López-Labrador, F. Xavier; Maier, M.; Majumdar, M.; Midgley, S.; Mirand, A.; Morley, U.; Nordbø, Svein Arne; Oikarinen, S; Osman, H; Papa, A; Pellegrinelli, L; Piralla, A; Rabella, N; Richter, J; Smith, M; Söderlund Strand, A; Templeton, K; Vipond, B; Vuorinen, T; Williams, C; Wollants, E; Zakikhany, K; Fischer, T. K.; Harvala, H; Simmonds, P (Journal article; Peer reviewed, 2019)
      Polymerase chain reaction (PCR) detection has become the gold standard for diagnosis and typing of enterovirus (EV) and human parechovirus (HPeV) infections. Its effectiveness depends critically on using the appropriate ...
    • A massive parallel sequencing workflow for diagnostic genetic testing of mismatch repair genes 

      Hansen, Maren Fridtjofsen; Neckmann, Ulrike; Lavik, Liss Anne; Vold, Trine; Gilde, Bodil; Toft, Ragnhild Karlgård; Sjursen, Wenche (Journal article; Peer reviewed, 2014)
      The purpose of this study was to develop a massive parallel sequencing (MPS) workflow for diagnostic analysis of mismatch repair (MMR) genes using the GS Junior system (Roche). A pathogenic variant in one of four MMR genes, ...
    • A meta-analysis of constraint-induced movement therapy after stroke 

      Thrane, Gyrd; Friborg, Oddgeir; Anke, Audny; Indredavik, Bent (Journal article; Peer reviewed, 2014)
      Objective: To evaluate the effect of constraint-induced movement therapy in adult stroke patients and to examine the impact of time since stroke and various treatment modalities. Data sources: PubMed, EMBASE, Cochrane and ...
    • A much valued tool that also brings ethical dilemmas-a qualitative study of Norwegian midwives' experiences and views on the role of obstetric ultrasound 

      Åhman, Annika; Edvardsson, Kristina; Fagerli, Anita; Darj, Elisabeth; Holmlund, Sofia; Small, Rhonda; Mogren, Ingrid (Journal article; Peer reviewed, 2019)
      Background: Midwives are the main providers of routine antenatal care services including the routine ultrasound examination in Norway. The ultrasound examination can be perceived by expectant parents not only as a medical ...
    • A much valued tool that also brings ethical dilemmas-a qualitative study of Norwegian midwives' experiences and views on the role of obstetric ultrasound 

      Åhman, Annika; Edvardsson, Kristina; Fagerli, Anita; Darj, Elisabeth; Holmlund, Sofia; Small, Rhonda; Mogren, Ingrid (Journal article; Peer reviewed, 2019)
      Background Midwives are the main providers of routine antenatal care services including the routine ultrasound examination in Norway. The ultrasound examination can be perceived by expectant parents not only as a medical ...
    • A multi-center comparison of vO2peak trainability between interval training and moderate intensity continuous training 

      Williams, Camilla J.; Gurd, Brendon J.; Bonafiglia, Jacob T.; Voisin, Sarah; Li, Zhixiu; Harvey, Nicholas; Croci, Ilaria; Taylor, Jenna L; Gajanand, Trishan; Ramos, Joyce S.; Fassett, Robert G.; Little, Jonathan P.; Francois, Monique E.; Hearon, Christopher M.; Sarma, Satyam; Janssen, Sylvan L.J.E.; Van Craenenbroeck, Emeline M.; Beckers, Paul; Cornelissen, Véronique A.; Pattyn, Nele; Howden, Erin J.; Keating, Shelley E.; Bye, Anja; Stensvold, Dorthe; Wisløff, Ulrik; Papadimitriou, Ioannis; Yan, Xu; Bishop, David J.; Eynon, Nir; Coombes, Jeff S. (Journal article; Peer reviewed, 2019)
      There is heterogeneity in the observed www.frontiersin.orgO2peak response to similar exercise training, and different exercise approaches produce variable degrees of exercise response (trainability). The aim of this study ...
    • A multiparameter model for non-invasive detection of hypoglycemia 

      Elvebakk, Ole; Tronstad, Christian; Birkeland, Kåre I.; Jenssen, Trond Geir; Bjørgaas, Marit Ragnhild Rokne; Gulseth, Hanne Løvdal; Kalvøy, Håvard; Høgetveit, Jan Olav; Martinsen, Ørjan Grøttem (Journal article; Peer reviewed, 2019)
      Objective: Severe hypoglycemia is the most serious acute complication for people with type 1 diabetes (T1D). Approximately 25% of people with T1D have impaired ability to recognize impending hypoglycemia, and nocturnal ...
    • A new acoustic coupling fluid with ability to reduce ultrasound imaging artefacts in brain tumour surgery - a phase I study 

      Unsgård, Geirmund; Sagberg, Lisa Millgård; Muller, Sebastien; Selbekk, Tormod (Journal article; Peer reviewed, 2019)
      Background Anovel acoustic coupling fluid (ACF), with the potential to reduce surgically induced image artefacts during intraoperative ultrasound imaging in brain tumour surgery, has been evaluated with respect to image ...
    • A property-based analysis of human transcription factors 

      Bahrami, Shahram; Ehsani, Rezvan; Drabløs, Finn (Journal article; Peer reviewed, 2015)
      Background Transcription factors are essential proteins for regulating gene expression. This regulation depends upon specific features of the transcription factors, including how they interact with DNA, how they interact ...
    • A prospective study examining cachexia predictors in patients with incurable cancer 

      Vagnildhaug, Ola Magne; Brunelli, Cinzia; Hjermstad, Marianne Jensen; Strasser, Florian; Baracos, Vickie; Wilcock, Andrew; Nabal, María; Kaasa, Stein; Laird, Barry J; Solheim, Tora Skeidsvoll (Journal article; Peer reviewed, 2019)
      Background Early intervention against cachexia necessitates a predictive model. The aims of this study were to identify predictors of cachexia development and to create and evaluate accuracy of a predictive model based ...
    • A randomized study on migration of the Spectron EF and the Charnley flanged 40 cemented femoral components using radiostereometric analysis at 2 years 

      Kadar, Thomas; Hallan, Geir; Aamodt, Arild; Indrekvam, Kari; Badawy, Mona; Havelin, Leif Ivar; Stokke, Terje; Haugan, Kristin; Espehaug, Birgitte; Furnes, Ove (Journal article; Peer reviewed, 2011)
      Background and purpose We performed a randomized study to determine the migration patterns of the Spectron EF femoral stem and to compare them with those of the Charnley stem, which is regarded by many as the gold standard ...
    • A small molecule activator of AKT does not reduce ischemic injury of the rat heart 

      Moreira, Jose Bianco Nascimento; Wohlwend, Martin; Alves, Marcia Netto Magalhaes; Wisløff, Ulrik; Bye, Anja (Journal article; Peer reviewed, 2015)
      Background Activation of protein kinase AKT is required for cardioprotection by ischemic preconditioning, and transgenic overexpression of AKT protects the heart against ischemia. However, it is unknown whether acute ...
    • Accuracy of breast cancer lesion classification using intravoxel incoherent motion diffusion-weighted imaging is improved by the inclusion of global or local prior knowledge with bayesian methods 

      Vidic, Igor; Jerome, Neil Peter; Bathen, Tone Frost; Goa, Pål Erik; While, Peter Thomas (Journal article; Peer reviewed, 2019)
      Background Diffusion‐weighted MRI (DWI) has potential to noninvasively characterize breast cancer lesions; models such as intravoxel incoherent motion (IVIM) provide pseudodiffusion parameters that reflect tissue perfusion, ...
    • Activins as Dual Specificity TGF-β Family Molecules: SMAD-Activation via Activin- and BMP-Type 1 Receptors 

      Olsen, Oddrun Elise; Hella, Hanne; Elsaadi, Samah; Jacobi, Carsten; Martinez-Hackert, Erik; Holien, Toril (Peer reviewed; Journal article, 2020)
      Activins belong to the transforming growth factor (TGF)-β family of multifunctional cytokines and signal via the activin receptors ALK4 or ALK7 to activate the SMAD2/3 pathway. In some cases, activins also signal via the ...
    • Adherence to clinical guidelines for Barrett’s esophagus 

      Holmberg, Dag; Ness-Jensen, Eivind; Mattsson, Fredrik; Lagergren, Jesper (Journal article; Peer reviewed, 2019)
      Background and aim: Clinical guidelines recommend endoscopy surveillance at given intervals or endoscopic therapy for Barrett’s esophagus with low-grade dysplasia (LGD) and high-grade dysplasia (HGD). Whether these guidelines ...