Browsing St. Olavs hospital by Author "Dale, Ola"
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Innate immune signalling genetics of pain, cognitive dysfunction and sickness symptoms in cancer pain patients treated with transdermal fentanyl
Barratt, Daniel T.; Klepstad, Pål; Dale, Ola; Kaasa, Stein; Somogyi, Andrew A. (Peer reviewed; Journal article, 2015)Common adverse symptoms of cancer and chemotherapy are a major health burden; chief among these is pain, with opioids including transdermal fentanyl the mainstay of treatment. Innate immune activation has been implicated ... -
The pharmacokinetic interaction between nasally administered naloxone and the opioid remifentanil in human volunteers
Tylleskär, Ida; Skarra, Sissel; Skulberg, Arne Kristian; Dale, Ola (Journal article; Peer reviewed, 2021)Purpose Remifentanil has been shown to increase the bioavailability of nasally administered naloxone. The aim of this study was to explore the nature of this observation. Methods We analysed samples from three pharmacokinetic ... -
Pharmacokinetics of a novel, approved, 1.4-mg intranasal naloxone formulation for reversal of opioid overdose—a randomized controlled trial
Skulberg, Arne Kristian; Åsberg, Anders; Zare, Hasse Khiabani; Røstad, Hilde; Tylleskär, Ida; Dale, Ola (Peer reviewed; Journal article, 2019)Background and aims Intranasal (i.n.) naloxone is an established treatment for opioid overdose. Anyone likely to witness an overdose should have access to the antidote. We aimed to determine whether an i.n. formulation ... -
Take-home naloxone for the emergency interim management of opioid overdose: The public health application of an emergency medicine
Strang, John; McDonald, Rebecca; Campbell, Gabrielle; Degenhardt, Louisa; Nielsen, Suzanne; Ritter, Alison; Dale, Ola (Peer reviewed; Journal article, 2019)Naloxone is a well-established essential medicine for the treatment of life-threatening heroin/opioid overdose in emergency medicine. Over two decades, the concept of ‘take-home naloxone’ has evolved, comprising pre-provision ...