Browsing Publikasjoner fra Cristin - St. Olavs hospital by Author "Aasly, Jan"
Now showing items 1-6 of 6
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Cerebrospinal Fluid Concentration of Key Autophagy Protein Lamp2 Changes Little During Normal Aging
Loeffler, David A.; Klaver, Andrea C.; Coffey, Mary P.; Aasly, Jan (Peer reviewed; Journal article, 2018)Autophagy removes both functional and damaged intracellular macromolecules from cells via lysosomal degradation. Three autophagic mechanisms, namely macroautophagy, chaperone-mediated autophagy (CMA), and microautophagy, ... -
Genetically-controlled Vesicle-Associated Membrane Protein 1 expression may contribute to Alzheimer's pathophysiology and susceptibility
Sevlever, Daniel; Zou, Fang Geng; Ma, Li; Carrasquillo, Sebastian; Crump, Michael G; Culley, Oliver J; Hunter, Talisha A; Bisceglio, Gina; Younkin, Linda; Allen, Mariet; Carrasquillo, Minerva; Sando, Sigrid Botne; Aasly, Jan; Dickson, Dennis W; Graff-Radford, Neill; Petersen, Ronald C.; Morgan, Kevin; Belbin, Olivia (Journal article; Peer reviewed, 2015)Background Alzheimer’s disease is a neurodegenerative disorder in which extracellular deposition of β-amyloid (Aβ) oligomers causes synaptic injury resulting in early memory loss, altered homeostasis, accumulation of ... -
Increased Mortality in Young-Onset Parkinson's Disease
Hustad, Eldbjørg; Myklebust, Tor Åge; Gulati, Sasha; Aasly, Jan (Peer reviewed; Journal article, 2021)Objective Few studies have followed Parkinson’s disease (PD) patients from the time of diagnosis to the date of death. This study compared mortality in the Trondheim PD cohort to the general population, investigated causes ... -
Increased Oxidative Stress Markers in Cerebrospinal Fluid from Healthy Subjects with Parkinson's Disease-Associated LRRK2 Gene Mutations
Loeffler, David A.; Klaver, Andrea C.; Coffey, Mary P.; Aasly, Jan; LeWitt, Peter A. (Peer reviewed; Journal article, 2017)Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most frequent cause of inherited Parkinson’s disease (PD). The most common PD-associated LRRK2 mutation, G2019S, induces increased production of reactive ... -
Multifactorial assessment of Parkinson’s disease course and outcomes using trajectory modeling in a multiethnic, multisite cohort – extension of the LONG-PD study
Chase, Bruce A.; Krueger, Rejko; Pavelka, Lukas; Chung, Sun Ju; Aasly, Jan; Dardiotis, Efthimios; Premkumar, Ashvini P.; Schoneburg, Bernadette; Kartha, Ninith; Aunaetitrakul, Navamon; Frigerio, Roberta; Maraganore, Demetrius; Markopoulou, Katerina (Peer reviewed; Journal article, 2023)Background: The severity, progression, and outcomes of motor and non-motor symptoms in Parkinson’s disease (PD) are quite variable. Following PD cohorts holds promise for identifying predictors of disease severity and ... -
What have we learned from cerebrospinal fluid studies about biomarkers for detecting LRRK2 Parkinson's disease patients and healthy subjects with Parkinson's-associated LRRK2 mutations?
Loeffler, David A.; Aasly, Jan; LeWitt, Peter A.; Coffey, Mary P. (Peer reviewed; Journal article, 2019)Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most common known cause of autosomal dominant Parkinson’s disease (PD) and sporadic PD (sPD). The clinical presentation of LRRK2 PD is similar to sPD, and ...