dc.contributor.author | Petrovic, Voin | |
dc.contributor.author | Nepal, Anala | |
dc.contributor.author | Olaisen, Camilla | |
dc.contributor.author | Bachke, Siri | |
dc.contributor.author | Hira, Jonathan | |
dc.contributor.author | Søgaard, Caroline Krogh | |
dc.contributor.author | Røst, Lisa Marie | |
dc.contributor.author | Misund, Kristine | |
dc.contributor.author | Andreassen, Trygve | |
dc.contributor.author | Melø, Torun Margareta | |
dc.contributor.author | Bartosova, Zdenka | |
dc.contributor.author | Bruheim, Per | |
dc.contributor.author | Otterlei, Marit | |
dc.date.accessioned | 2018-05-25T07:16:50Z | |
dc.date.available | 2018-05-25T07:16:50Z | |
dc.date.created | 2018-04-16T12:58:37Z | |
dc.date.issued | 2018 | |
dc.identifier.issn | 2072-6643 | |
dc.identifier.uri | http://hdl.handle.net/11250/2499168 | |
dc.description.abstract | The use of garlic and garlic-based extracts has been linked to decreased incidence of cancer in epidemiological studies. Here we examine the molecular and cellular activities of a simple homemade ethanol-based garlic extract (GE). We show that GE inhibits growth of several different cancer cells in vitro, as well as cancer growth in vivo in a syngeneic orthotopic breast cancer model. Multiple myeloma cells were found to be especially sensitive to GE. The GE was fractionated using solid-phase extractions, and we identified allicin in one GE fraction; however, growth inhibitory activities were found in several additional fractions. These activities were lost during freeze or vacuum drying, suggesting that the main anti-cancer compounds in GE are volatile. The anti-cancer activity was stable for more than six months in −20 °C. We found that GE enhanced the activities of chemotherapeutics, as well as MAPK and PI3K inhibitors. Furthermore, GE affected hundreds of proteins involved in cellular signalling, including changes in vital cell signalling cascades regulating proliferation, apoptosis, and the cellular redox balance. Our data indicate that the reduced proliferation of the cancer cells treated by GE is at least partly mediated by increased endoplasmic reticulum (ER) stress | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | MDPI | nb_NO |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Anti-Cancer Potential of Homemade Fresh Garlic Extract Is Related to Increased Endoplasmic Reticulum Stress | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.description.version | publishedVersion | nb_NO |
dc.source.volume | 10 | nb_NO |
dc.source.journal | Nutrients | nb_NO |
dc.source.issue | 4 | nb_NO |
dc.identifier.doi | 10.3390/nu10040450 | |
dc.identifier.cristin | 1579539 | |
dc.description.localcode | © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | nb_NO |
cristin.unitcode | 194,65,15,0 | |
cristin.unitcode | 194,66,15,0 | |
cristin.unitcode | 194,65,25,0 | |
cristin.unitname | Institutt for klinisk og molekylær medisin | |
cristin.unitname | Institutt for bioteknologi og matvitenskap | |
cristin.unitname | Institutt for sirkulasjon og bildediagnostikk | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |