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dc.contributor.authorElschot, Mattijs
dc.contributor.authorSelnæs, Kirsten Margrete
dc.contributor.authorSandsmark, Elise
dc.contributor.authorKrüger-Stokke, Brage
dc.contributor.authorStørkersen, Øystein
dc.contributor.authorGiskeødegård, Guro F.
dc.contributor.authorTessem, May-Britt
dc.contributor.authorMoestue, Siver Andreas
dc.contributor.authorBertilsson, Helena
dc.contributor.authorBathen, Tone Frost
dc.date.accessioned2017-10-24T08:38:19Z
dc.date.available2017-10-24T08:38:19Z
dc.date.created2017-10-23T09:00:57Z
dc.date.issued2017
dc.identifier.issn0161-5505
dc.identifier.urihttp://hdl.handle.net/11250/2461632
dc.description.abstractThe objective of this study is to investigate if quantitative imaging features derived from combined 18F-Fluciclovine Positron Emission Tomograpy (PET) / multiparametric Magnetic Resonance Imaging (MRI) show potential for detection and characterization of primary prostate cancer. Methods: Twenty-eight (28) patients diagnosed with high-risk prostate cancer underwent simultaneous 18F-Fluciclovine PET/MRI before radical prostatectomy. Volumes-of-interest (VOIs) of prostate tumors, benign prostatic hyperplasia (BPH) nodules, prostatitis, and healthy tissue were delineated on T2-weighted images using histology as a reference. Tumor VOIs were marked as high-grade (≥ Gleason Grade group 3) or not. MRI and PET features were extracted on the voxel and VOI-level. Partial least-squared discriminant analysis (PLS-DA) with double leave-one-patient-out cross validation was performed to classify tumor from benign tissue (BPH, prostatitis, healthy tissue) and high-grade tumor from other tissue (low-grade tumor, benign tissue). The performances of PET, MRI, and combined PET/MRI features were compared using the area under the receiver operating characteristic curve (AUC). Results: Voxel and VOI features were extracted from 40 tumor (26 high-grade), 36 BPH, 6 prostatitis, and 37 healthy tissue VOIs. PET/MRI performed better than MRI and PET for classification of tumor vs benign tissue (voxel: AUC 87%, 81%, and 83%; VOI: AUC 96%, 93%, and 93%, respectively) and high-grade tumor vs other tissue (voxel: AUC 85%, 79%, and 81%; VOI: AUC 93%, 93%, and 91%, respectively). T2-weighted MRI, diffusion-weighted MRI and PET features were most important for classification. Conclusion: Combined 18F-Fluciclovine PET/multiparametric MRI shows potential for improving detection and characterization of high-risk prostate cancer, in comparison to MRI and PET alone.nb_NO
dc.language.isoengnb_NO
dc.publisherSociety of Nuclear Medicinenb_NO
dc.titleCombined 18F-Fluciclovine PET/MRI shows potential for detection and characterization of high-risk prostate cancernb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionacceptedVersionnb_NO
dc.source.journalJournal of Nuclear Medicinenb_NO
dc.identifier.doi10.2967/jnumed.117.198598
dc.identifier.cristin1506616
dc.description.localcode© 2017. This is the authors’ accepted and refereed manuscript to the article. The final publication is available at http://jnm.snmjournals.org/content/early/2017/10/05/jnumed.117.198598nb_NO
cristin.unitcode194,65,25,0
cristin.unitcode194,65,15,0
cristin.unitnameInstitutt for sirkulasjon og bildediagnostikk
cristin.unitnameInstitutt for klinisk og molekylær medisin
cristin.ispublishedtrue
cristin.fulltextpostprint
cristin.qualitycode2


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