dc.contributor.author | Juuhl-Langseth, Monica | |
dc.contributor.author | Hartberg, Cecilie Bhandari | |
dc.contributor.author | Holmen, Aina | |
dc.contributor.author | Thormodsen, Rune | |
dc.contributor.author | Groote, Inge Rasmus | |
dc.contributor.author | Rimol, Lars Morten | |
dc.contributor.author | Emblem, Kyrre Eeg | |
dc.contributor.author | Agartz, Ingrid | |
dc.contributor.author | Rund, Bjørn Rishovd | |
dc.date.accessioned | 2015-11-25T11:00:59Z | |
dc.date.accessioned | 2016-01-05T10:17:56Z | |
dc.date.available | 2015-11-25T11:00:59Z | |
dc.date.available | 2016-01-05T10:17:56Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | PLoS ONE 2015, 10:e0130435(7) | nb_NO |
dc.identifier.issn | 1932-6203 | |
dc.identifier.uri | http://hdl.handle.net/11250/2372570 | |
dc.description.abstract | Background:
Both brain structural abnormalities and neurocognitive impairments are core features of
schizophrenia. We have previously reported enlargements in subcortical brain structure volumes
and impairment of neurocognitive functioning as measured by the MATRICS Cognitive
Consensus Battery (MCCB) in early onset schizophrenia spectrum disorders (EOS). To
our knowledge, no previous study has investigated whether neurocognitive performance
and volumetric abnormalities in subcortical brain structures are related in EOS.
Methods:
Twenty-four patients with EOS and 33 healthy controls (HC) were included in the study.
Relationships between the caudate nucleus, the lateral and fourth ventricles volumes and
neurocognitive performance were investigated with multivariate linear regression analyses.
Intracranial volume, age, antipsychotic medication and IQ were included as independent
predictor-variables.
Results:
The caudate volume was negatively correlated with verbal learning performance uniquely in
the EOS group (r=-.454, p = .034). There were comparable positive correlations between
the lateral ventricular volume and the processing speed, attention and reasoning and problem
solving domains for both the EOS patients and the healthy controls. Antipsychotic medication
was related to ventricular enlargements, but did not affect the brain structure-function
relationship.
Conclusion:
Enlargement of the caudate volume was related to poorer verbal learning performance in
patients with EOS. Despite a 32% enlargement of the lateral ventricles in the EOS group,
associations to processing speed, attention and reasoning and problem solving were similar
for both the EOS and the HC groups. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | Public Library of Science | nb_NO |
dc.title | Impaired verbal learning is associated with larger caudate volumes in early onset schizophrenia spectrum disorders | nb_NO |
dc.type | Journal article | nb_NO |
dc.date.updated | 2015-11-25T11:00:59Z | |
dc.source.volume | 10 | nb_NO |
dc.source.journal | PLoS ONE | nb_NO |
dc.source.issue | 7 | nb_NO |
dc.identifier.doi | 10.1371/journal.pone.0130435 | |
dc.identifier.cristin | 1285567 | |
dc.description.localcode | © 2015 Juuhl-Langseth et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | nb_NO |