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dc.contributor.authorJuuhl-Langseth, Monica
dc.contributor.authorHartberg, Cecilie Bhandari
dc.contributor.authorHolmen, Aina
dc.contributor.authorThormodsen, Rune
dc.contributor.authorGroote, Inge Rasmus
dc.contributor.authorRimol, Lars Morten
dc.contributor.authorEmblem, Kyrre Eeg
dc.contributor.authorAgartz, Ingrid
dc.contributor.authorRund, Bjørn Rishovd
dc.date.accessioned2015-11-25T11:00:59Z
dc.date.accessioned2016-01-05T10:17:56Z
dc.date.available2015-11-25T11:00:59Z
dc.date.available2016-01-05T10:17:56Z
dc.date.issued2015
dc.identifier.citationPLoS ONE 2015, 10:e0130435(7)nb_NO
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/11250/2372570
dc.description.abstractBackground: Both brain structural abnormalities and neurocognitive impairments are core features of schizophrenia. We have previously reported enlargements in subcortical brain structure volumes and impairment of neurocognitive functioning as measured by the MATRICS Cognitive Consensus Battery (MCCB) in early onset schizophrenia spectrum disorders (EOS). To our knowledge, no previous study has investigated whether neurocognitive performance and volumetric abnormalities in subcortical brain structures are related in EOS. Methods: Twenty-four patients with EOS and 33 healthy controls (HC) were included in the study. Relationships between the caudate nucleus, the lateral and fourth ventricles volumes and neurocognitive performance were investigated with multivariate linear regression analyses. Intracranial volume, age, antipsychotic medication and IQ were included as independent predictor-variables. Results: The caudate volume was negatively correlated with verbal learning performance uniquely in the EOS group (r=-.454, p = .034). There were comparable positive correlations between the lateral ventricular volume and the processing speed, attention and reasoning and problem solving domains for both the EOS patients and the healthy controls. Antipsychotic medication was related to ventricular enlargements, but did not affect the brain structure-function relationship. Conclusion: Enlargement of the caudate volume was related to poorer verbal learning performance in patients with EOS. Despite a 32% enlargement of the lateral ventricles in the EOS group, associations to processing speed, attention and reasoning and problem solving were similar for both the EOS and the HC groups.nb_NO
dc.language.isoengnb_NO
dc.publisherPublic Library of Sciencenb_NO
dc.titleImpaired verbal learning is associated with larger caudate volumes in early onset schizophrenia spectrum disordersnb_NO
dc.typeJournal articlenb_NO
dc.date.updated2015-11-25T11:00:59Z
dc.source.volume10nb_NO
dc.source.journalPLoS ONEnb_NO
dc.source.issue7nb_NO
dc.identifier.doi10.1371/journal.pone.0130435
dc.identifier.cristin1285567
dc.description.localcode© 2015 Juuhl-Langseth et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.nb_NO


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