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dc.contributor.authorLarsen, Eivind La Pueblanb_NO
dc.date.accessioned2014-12-19T13:46:34Z
dc.date.accessioned2015-12-22T11:45:07Z
dc.date.available2014-12-19T13:46:34Z
dc.date.available2015-12-22T11:45:07Z
dc.date.created2011-09-06nb_NO
dc.date.issued2010nb_NO
dc.identifier439357nb_NO
dc.identifier.isbn82-471-2471-0 (printed ver.)nb_NO
dc.identifier.urihttp://hdl.handle.net/11250/2370225
dc.description.abstractOptical measurement techniques have a large potential as diagnostic tools in medicine. This thesis covers multiple biomedical applications of optical spectroscopy and hyperspectral imaging. Main topics have been monitoring of photodynamic therapy of bladder cancer, age determination of bruises for forensic applications, and tissue characterization, including hyperspectral characterization of atherosclerotic plaques. Diffuse reflectance spectroscopy was found to be a suitable modality to monitor skin reactions following non-penetrating trauma, and may be a candidate to accurately and objectively determine the age of such bruises, a large improvement over current age determination methods. Hyperspectral imaging is another candidate for this purpose, a large advantage being that it records the entire scene and thereby allows both the spectral and spatial development of the injury to be monitored. The combination of hyperspectral imaging, statistical image analysis and diffusion modeling was proved to be a versatile and powerful tool for characterization of bruised skin and vascular structures (e. g. blood perfusion). The results show that these tools can be used to derive information about the depth and structure of the vasculature. The combination of reflectance and fluorescence hyperspectral imaging has also been demonstrated in characterization of atherosclerotic lesions, where hyperspectral imaging and image analysis were shown to identify the complexity and large heterogeneity of such plaques as compared to histologynb_NO
dc.languageengnb_NO
dc.publisherNTNUnb_NO
dc.relation.ispartofseriesDoktoravhandlinger ved NTNU, 1503-8181nb_NO
dc.titleBiomedical Applications of Diffuse Reflectance Spectroscopy and Hyperspectral Imagingnb_NO
dc.typeDoctoral thesisnb_NO
dc.contributor.departmentNorges teknisk-naturvitenskapelige universitet, Fakultet for informasjonsteknologi, matematikk og elektroteknikk, Institutt for elektronikk og telekommunikasjonnb_NO
dc.description.degreePhD i elektronikk og telekommunikasjonnb_NO
dc.description.degreePhD in Electronics and Telecommunication


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