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    • Intake of Boiled Potato in Relation to Cardiovascular Disease Risk Factors in a Large Norwegian Cohort: The HUNT Study. 

      Moholdt, Trine; Devlin, BL; Nilsen, Tom Ivar Lund (Journal article; Peer reviewed, 2019)
      Overall potato consumption is positively associated with cardiovascular disease (CVD) risk factors, such as measures of adiposity. However, few studies have explicitly stated the preparation method of potatoes, which may ...

    • Integrated stress response pathways induced by DHA in human colon cancer cell lines 

      Sandmoe, Malin Alise (Master thesis, 2016)
      Estimates show that 95% of all cancers can be attributed to environmental factors, and diet represents 30-35% of this. The omega-3 polyunsaturated fatty acid docosahexaenoic acid (DHA, 22:6 n-3) is an essential fatty acid ...

    • Integrative clustering reveals a novel split in the luminal A subtype of breast cancer with impact on outcome 

      Aure, Miriam Ragle; Vitelli, Valeria; Jernström, Sandra Johanna; Kumar, Surendra; Krohn, Marit; Due, Eldri Undlien; Haukaas, Tonje Husby; Leivonen, Suvi-Katri; Vollan, Hans Kristian Moen; Luders, Torben; Rødland, Einar Andreas; Vaske, Charles; Zhao, Wei; Møller, Elen Kristine; Nord, Silje; Giskeødegård, Guro F.; Bathen, Tone Frost; Caldas, Carlos; Tramm, Trine; Alsner, Jan; Overgaard, Jens; Geisler, Jürgen; Bukholm, Ida Rashida Khan; Naume, Bjørn; Schlichting, Ellen; Sauer, Torill; Mills, Gordon B.; Kåresen, Rolf; Mælandsmo, Gunhild; Lingjærde, Ole Christian; Frigessi, Arnoldo; Kristensen, Vessela N.; Børresen-Dale, Anne-Lise; Sahlberg, Kristine Kleivi; OSBREAC, Oslo Breast Cancer Consortium (Journal article; Peer reviewed, 2017)
      Background Breast cancer is a heterogeneous disease at the clinical and molecular level. In this study we integrate classifications extracted from five different molecular levels in order to identify integrated ...

    • Integrative effect of carvedilol and aerobic exercise training therapies on improving cardiac contractility and remodeling in heart failure mice 

      Vanzelli, Andréa S.; Medeiros, Alessandra; Rolim, Natale Pinheiro Lage; Bartholomeu, Jan B.; Cunha, Telma F.; Bechara, Luiz G.; Gomes, Enéas R.M.; Mattos, Katt C.; Sirvente, Raquel; Salemi, Vera; Mady, Charles; Negrao, Carlos E.; Guatimosim, Silvia; Brum, Patricia C. (Journal article; Peer reviewed, 2013)
      The use of β-blockers is mandatory for counteracting heart failure (HF)-induced chronic sympathetic hyperactivity, cardiac dysfunction and remodeling. Importantly, aerobic exercise training, an efficient nonpharmacological ...

    • Integrative metabolic and transcriptomic profiling of prostate cancer tissue containing reactive stroma 

      Andersen, Maria Karoline; Rise, Kjersti; Giskeødegård, Guro F.; Richardsen, Elin; Bertilsson, Helena; Størkersen, Øystein; Bathen, Tone Frost; Rye, Morten Beck; Tessem, May-Britt (Journal article; Peer reviewed, 2018)
      Reactive stroma is a tissue feature commonly observed in the tumor microenvironment of prostate cancer and has previously been associated with more aggressive tumors. The aim of this study was to detect differentially ...

    • An Intelligent Power and Energy Management System for Fuel Cell/Battery Hybrid Electric Vehicle Using Reinforcement Learning 

      Reddy, Namireddy Praveen; Pasdeloup, David Francis Pierre; Zadeh, Mehdi Karbalaye; Skjetne, Roger (Journal article, 2019)
      Hybrid electric vehicles powered by fuel cells and batteries have attracted significant attention as they have the potential to eliminate emissions from the transport sector. However, fuel cells and batteries have several ...

    • Intensive care for the very old 

      Andersen, Finn Husøy (Doctoral theses at NTNU;2017:166, Doctoral thesis, 2017)
      Introduction: The older population is expected to increase markedly during the next decades. The life expectancy of older patients is increasing, but the prevalence of conditions that require ICU treatment is also growing. ...

    • Interleukin-6 inhibition in ST-elevation myocardial infarction: Immune cell profile in the randomised ASSAIL-MI trial 

      Huse, Camilla; Anstensrud, Anne Kristine; Michelsen, Annika Elisabet; Ueland, Thor; Broch, Kaspar; Woxholt, Sindre; Yang, Kuan; Sharma, Kapil Kishore; Tøllefsen, Ingvild Maria; Bendz, Bjørn; Amundsen, Brage H.; Damås, Jan Kristian; Berg, Erlend Sturle; Bjørkelund, Elisabeth; Quiles-Jiménez, Ana M T; Bjerkeli, Vigdis; Bendz, Christina; Kleveland, Ola; Stensæth, Knut Haakon; Opdahl, Anders; Kløw, Nils-Einar; Andersen, Geir Øystein; Wiseth, Rune; Halvorsen, Bente; Gullestad, Lars; Seljeflot, Ingebjørg; Aukrust, Pål; Osnes, Liv T. N.; Dahl, Tuva Børresdatter (Peer reviewed; Journal article, 2022)
      We recently showed that interleukin (IL)-6 inhibition by tocilizumab improves myocardial salvage in ST-elevation myocardial infarction (STEMI). However, the mechanisms for this effect are not clear. Methods In this ...

    • Interleukin-6 receptor inhibition in non-ST-elevation myocardial infarction - Results from a randomized clinical trial 

      Kleveland, Ola (Doctoral theses at NTNU;2019:50, Doctoral thesis, 2019)
      Norsk sammenfatning: Inhibering av interleukin-6 ved hjerteinfarkt uten ST-segment elevasjon i EKG. Resultater fra en randomisert klinisk studie. Dette arbeidet inneholder resultater fra en klinisk, randomisert, ...

    • Interleukin-6 receptor inhibition with tocilizumab induces a selective and substantial increase in plasma IP-10 and MIP-1β in non-ST-elevation myocardial infarction 

      Kleveland, Ola; Ueland, Thor; Kunszt, Gabor; Bratlie, Marte; Yndestad, Arne; Broch, Kaspar; Holte, Espen; Ryan, Liv; Amundsen, Brage H.; Bendz, Bjørn; Aakhus, Svend; Espevik, Terje; Halvorsen, Bente; Mollnes, Tom Eirik; Wiseth, Rune; Gullestad, Lars; Aukrust, Pål; Damås, Jan Kristian (Journal article; Peer reviewed, 2018)
      Aim To evaluate the effect of interleukin-6 inhibition with tocilizumab on the cytokine network in patients with acute non-ST-elevation myocardial infarction (NSTEMI). Methods 117 patients with acute NSTEMI were randomised ...

    • International patent applications for non-injectable naloxone for opioid overdose reversal: Exploratory search and retrieve analysis of the Patent Scope database 

      McDonald, Rebecca; Danielsson Glende, Øyvind; Dale, Ola; Strang, John (Journal article; Peer reviewed, 2017)
      Issues. Non-injectable naloxone formulations are being developed for opioid overdose reversal, but only limited data have been published in the peer-reviewed domain. Through examination of a hitherto-unsearched database, ...

    • Interpersonal problems as a predictor of pain catastrophizing in patients with chronic pain 

      Ryum, Truls; Jacobsen, Henrik Børsting; Borchgrevink, Petter Chr.; Landrø, Nils Inge; Stiles, Tore C (Peer reviewed; Journal article, 2019)
      Background and aims Pain catastrophizing has consistently been related to a variety of negative outcomes within chronic pain conditions, but competing models exist explaining the role of catastrophizing. According to the ...

    • Interplay of choline metabolites and genes in patient-derived breast cancer xenografts 

      Grinde, Maria Tunset; Skrbo, Nirma; Moestue, Siver Andreas; Rødland, Einar Andreas; Borgan, Eldrid; Kristian, Alexandr; Sitter, Beathe; Bathen, Tone; Børresen-Dale, Anne-Lise; Mælandsmo, Gunhild; Engebråten, Olav; Sørlie, Therese; Marangoni, Elisabetta; Gribbestad, Ingrid S (Journal article; Peer reviewed, 2014)
      Introduction Dysregulated choline metabolism is a well-known feature of breast cancer, but the underlying mechanisms are not fully understood. In this study, the metabolomic and transcriptomic characteristics of a large ...

    • Interstitial solute transport in 3D reconstructed neuropil occurs by diffusion rather than bulk flow 

      Holter, Karl Erik; Kehlet, Benjamin Dam; Devor, Anna; Sejnowski, Terrence J.; Dale, Anders M.; Omholt, Stig William; Ottersen, Ole Petter; Nagelhus, Erlend Arnulf; Mardal, Kent-Andre; Pettersen, Klas (Journal article; Peer reviewed, 2017)
      The brain lacks lymph vessels and must rely on other mechanisms for clearance of waste products, including amyloid β that may form pathological aggregates if not effectively cleared. It has been proposed that flow of ...

    • Interval training improves right ventricular function in a mouse model of cigarette smoke induced-chronic obstructive pulmonary disease 

      Berre, Anne Marie Ormbostad (Master thesis, 2014)
      Patients with chronic obstructive pulmonary disease (COPD) have impaired lung function and exercise tolerance reducing their quality of life and increasing mortality. In recent years, there has been a growing consensus ...

    • Interventional techniques to management of cancer-related pain: Clinical and critical aspects 

      Kurita, Geana Paula; Sjøgren, Per Johan E; Klepstad, Pål; Mercadante, Sebastiano (Journal article; Peer reviewed, 2019)
      Interventional techniques to manage cancer-related pain may be efficient treatment modalities in patients unresponsive or unable to tolerate systemic opioids. However, indication and selection of the right technique demand ...

    • Interventions and symptom relief in hospital palliative cancer care: results from a prospective longitudinal study 

      Thronæs, Morten; Løhre, Erik T; Kvikstad, Anne; Brenne, Elisabeth; Norvaag, Robin; Aalberg, Kathrine Otelie; Moen, Martine Kjølberg; Jakobsen, Gunnhild; Klepstad, Pål; Solberg, Arne; Solheim, Tora S (Journal article; Peer reviewed, 2021)
      Purpose To study the use of interventions and symptom relief for adult patients with incurable cancer admitted to an acute palliative care unit providing integrated oncology and palliative care services. Methods All ...

    • Intestinal injury in cardiac arrest is associated with multiple organ dysfunction: A prospective cohort study 

      Farbu, Bjørn Hoftun; Langeland, Halvor; Ueland, Thor; Michelsen, Annika Elisabet; Krüger, Andreas Jørstad; Klepstad, Pål; Nordseth, Trond (Peer reviewed; Journal article, 2023)
      Background The impact of intestinal injury in cardiac arrest is not established. The first aim of this study was to assess associations between clinical characteristics in out-of-hospital cardiac arrest (OHCA) and a ...

    • Intra-observer Variability in Segmentation of Glioblastomas 

      Stensjøen, Anne Line (Master thesis, 2014)
      Background: Glioblastomas are primary malignant brain tumors with poor prognosis. In study settings where tumor growth and treatment responses are assessed, tumor volumes are measured. To obtain valid volume measures ...

    • Intraoperative 3D ultrasound-guided resection of diffuse low-grade gliomas: radiological and clinical results 

      Bø, Hans Kristian; Solheim, Ole; Kvistad, Kjell Arne; Berntsen, Erik Magnus; Torp, Sverre Helge; Skjulsvik, Anne Jarstein; Reinertsen, Ingerid; Iversen, Daniel Høyer; Unsgård, Geirmund; Jakola, Asgeir S (Peer reviewed; Journal article, 2019)
      OBJECTIVE Extent of resection (EOR) and residual tumor volume are linked to prognosis in low-grade glioma (LGG) and there are various methods for facilitating safe maximal resection in such patients. In this prospective ...