Browsing Institutt for sirkulasjon og bildediagnostikk by Title
Now showing items 1215-1234 of 1943
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Naloksonnesespray – biotilgjengelighet og opptaksmønster i en fase 1-studie
(Journal article; Peer reviewed, 2019)Kameratredning med nalokson i nesespray kan forebygge dødsfall ved opioidoverdoser. For å få best mulig opptak av nalokson i nesen må sprayen gis med et lavt volum med høy medikamentkonsentrasjon. Målet med studien var å ... -
Naloxone for opioid overdose - Pharmacological aspects and dosing in clinical practice
(Doctoral theses at NTNU;2020:236, Doctoral thesis, 2020)Dødsfall fra opioidoverdoser er et stort folkehelseproblem og utdeling av nesespray med motgiften nalokson var foreslått som et tiltak for å redde liv. I 2012 fantes det ingen godkjente nesesprayer på markedet. Istedenfor ... -
Nanoparticle delivery to the brain - By focused ultrasound and self-assembled nanoparticle-stabilized microbubbles
(Journal article, 2015)The blood–brain barrier (BBB) constitutes a significant obstacle for the delivery of drugs into the central nervous system (CNS). Nanoparticles have been able to partly overcome this obstacle and can thus improve drug ... -
Nanoparticle Dynamics in Composite Hydrogels Exposed to Low-Frequency Focused Ultrasound
(Peer reviewed; Journal article, 2023)Pulsed focused ultrasound (FUS) in combination with microbubbles has been shown to improve delivery and penetration of nanoparticles in tumors. To understand the mechanisms behind this treatment, it is important to evaluate ... -
Nanoparticle Mediated P-Glycoprotein Silencing for Improved Drug Delivery across the Blood-Brain Barrier: A siRNA-Chitosan Approach
(Journal article; Peer reviewed, 2013)Background: Neonatal intermittent hyperoxia-hypoxia (IHH) is involved in the pathogenesis of retinopathy of prematurity. Whether similar oxygen fluctuations will create pathological changes in the grey and white matter ... -
Nanoparticle-stabilized microbubbles for multimodal imaging and drug delivery
(Journal article, 2015)Microbubbles (MBs) are routinely used as contrast agents for ultrasound imaging. The use of ultrasound in combination with MBs has also attracted attention as a method to enhance drug delivery. We have developed a technology ... -
Nanoparticles, ultrasound and microbubble mediated drug delivery in cancer models
(Doctoral theses at NTNU;2020:97, Doctoral thesis, 2020)Denne avhandlingen omhandler forbedring av kreftbehandling gjennom økt levering av cellegift til kreftvev ved bruk av nanopartikler eller ultralyd kombinert med mikrobobler. Ved å kapsle cellegift inn i nanopartikler kan ... -
Nanostructured lipid carriers for controlled and triggered drug delivery : synthesis and advanced characterisation
(Master thesis, 2016)The emerging field of nanomedicine allows development of targeted drug delivery systems that improves the efficiency and bioavailability of important therapeutics in the clinic. Translation of engineered nanoparticles for ... -
Nasal naloxone - A pilot study of the pharmacokinetics of a concentrated formulation
(Master thesis, 2017)Introduction: Naloxone is the antidote against heroin and other opioids. As a measure to combat overdose deaths, nasal naloxone is wanted for bystander administration by lay people. The objective of this study was to ... -
The Natural Course of Chronic Pain in a General Population: Stability and Change in an Eight-Wave Longitudinal Study Over Four Years (the HUNT Pain Study).
(Peer reviewed; Journal article, 2020)Epidemiological studies have to a little extent addressed the potential fluctuations of chronic pain over time, and there is a lack of information about the long-term course of pain using repeated measurements. We wanted ... -
Navigation Technology in Endovascular Aortic Repair
(Doktoravhandlinger ved NTNU, 1503-8181; 2013:62, Doctoral thesis, 2013)A number of diseases can affect the aorta, and endovascular (minimally invasive) techniques can be used to treat many of these conditions. During endovascular aortic repair, different instruments, such as catheters (plastic ... -
NAxtra magnetic nanoparticles for low-cost, efficient isolation of mammalian DNA and RNA
(Peer reviewed; Journal article, 2023)A cost-effective, viral nucleic acid (NA) isolation kit based on NAxtra magnetic nanoparticles was developed at the Norwegian University of Science and Technology in response to the shortage of commercial kits for isolation ... -
A needs assessment of resuscitative endovascular balloon occlusion of the aorta (REBOA) in non-traumatic out-of-hospital cardiac arrest in Norway
(Peer reviewed; Journal article, 2020)Introduction: Out of hospital cardiac arrest (OHCA) carries an 86% mortality rate in Norway. Resuscitative endovascular balloon occlusion of the aorta (REBOA) is a potential adjunct in management of non-traumatic cardiac ... -
Needs assessment of resuscitative endovascular balloon occlusion of the aorta (REBOA) in patients with major haemorrhage: A cross-sectional study
(Peer reviewed; Journal article, 2021)Background Resuscitative endovascular balloon occlusion of the aorta (REBOA) can be used as an adjunct treatment in traumatic abdominopelvic haemorrhage, ruptured abdominal aortic aneurysms, postpartum haemorrhage (PPH), ... -
NeoDoppler: New ultrasound technology for continous cerebral circulation monitoring in neonates.
(Journal article; Peer reviewed, 2019)BACKGROUND: There is a strong need for continuous cerebral circulation monitoring in neonatal care, since suboptimal cerebral blood flow may lead to brain injuries in preterm infants and other critically ill neonates. ... -
Nephrologists’ experiences with patient participation when long-term dialysis is required
(Peer reviewed; Journal article, 2021)Background For individuals in need of dialysis, patient participation is important when determining care goals and in decision making regarding dialysis modality. Nephrologists hold a key role in delivering evidence-based ... -
Nephronectin induced activation of intracellular signaling pathways in breast cancer
(Master thesis, 2016)The aim of this project was to characterize the intracellular signaling pathways induced by extracellular matrix protein (ECM) Nephronectin (Npnt) in cell line 66cl4. Cell line 66cl4 is a cell line from a mouse mammary ... -
Neural networks for parameter estimation in microstructural MRI: application to a diffusion-relaxation model of white matter
(Peer reviewed; Journal article, 2021)Specific features of white matter microstructure can be investigated by using biophysical models to interpret relaxation-diffusion MRI brain data. Although more intricate models have the potential to reveal more details ... -
Neural response analysis for brain-machine interfaces
(Journal article; Peer reviewed, 2019)Neurological disorders such as Alzheimers and Parkinsons diseases are associated with malfunctioning neurons, and neuronal signaling and communication pathways. Restoring the neuronal function is considered one of the ... -
Neuron-astrocyte interactions, pyruvate carboxylation and the pentose phosphate pathway in the neonatal rat brain
(Journal article; Peer reviewed, 2014)Glucose and acetate metabolism and the synthesis of amino acid neurotransmitters, anaplerosis, glutamate-glutamine cycling and the pentose phosphate pathway (PPP) have been extensively investigated in the adult, but not ...