Blar i Institutt for sirkulasjon og bildediagnostikk på tittel
Viser treff 1131-1150 av 1934
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Metabolic effects of signal transduction inhibition in cancer assessed by magnetic resonance spectroscopy
(Journal article; Peer reviewed, 2011)Despite huge efforts in development of drugs targeting oncogenic signalling, the number of such drugs entering clinical practice to date remains limited. Rational use of biomarkers for drug candidate selection and early ... -
Metabolic portraits of breast cancer by HR MAS MR spectroscopy of intact tissue samples
(Journal article; Peer reviewed, 2017)Despite progress in early detection and therapeutic strategies, breast cancer remains the second leading cause of cancer-related death among women globally. Due to the heterogeneity and complexity of tumor biology, breast ... -
Metabolic profiles of brain metastases
(Journal article; Peer reviewed, 2013)Metastasis to the brain is a feared complication of systemic cancer, associated with significant morbidity and poor prognosis. A better understanding of the tumor metabolism might help us meet the challenges in controlling ... -
Metabolic profiles of placenta in preeclampsia using HR-MAS MRS metabolomics
(Journal article; Peer reviewed, 2015)Introduction Preeclampsia is a heterogeneous gestational disease characterized by maternal hypertension and proteinuria, affecting 2–7% of pregnancies. The disorder is initiated by insufficient placental development, ... -
Metabolic profiling of breast cancer using ex vivo MR spectroscopy
(Doctoral thesis at NTNU;2016:110, Doctoral thesis, 2016) -
Metabolic profiling of colorectal cancer organoids: A comparison between high-resolution magic angle spinning magnetic resonance spectroscopy and solution nuclear magnetic resonance spectroscopy of polar extracts
(Peer reviewed; Journal article, 2022)Patient-derived cancer cells cultured in vitro are a cornerstone of cancer metabolism research. More recently, the introduction of organoids has provided the research community with a more versatile model system. Physiological ... -
Metabolic re-wiring of isogenic breast epithelial cell lines following epithelial to mesenchymal transition
(Journal article; Peer reviewed, 2017)Epithelial to mesenchymal transition (EMT) has implications in tumor progression and metastasis. Metabolic alterations have been described in cancer development but studies focused on the metabolic re-wiring that takes ... -
Metabolic reprogramming supports the invasive phenotype in malignant melanoma
(Journal article; Peer reviewed, 2015)Invasiveness is a hallmark of aggressive cancer like malignant melanoma, and factors involved in acquisition or maintenance of an invasive phenotype are attractive targets for therapy. We investigated melanoma phenotype ... -
Metabolic response to everolimus in patient-derived triple negative breast cancer xenografts
(Journal article; Peer reviewed, 2017)Patients with triple-negative breast cancer (TNBC) are unresponsive to endocrine and anti-HER2 pharmacotherapy, limiting their therapeutic options to chemotherapy. TNBC is frequently associated with abnormalities in the ... -
Metabolite and lipoprotein responses and prediction of weight gain during breast cancer treatment
(Journal article; Peer reviewed, 2018)Background Breast cancer treatment has metabolic side effects, potentially affecting risk of cardiovascular disease (CVD) and recurrence. We aimed to compare alterations in serum metabolites and lipoproteins during treatment ... -
Metabolomic biomarkers in serum and urine in women with preeclampsia
(Journal article, 2014)Objective To explore the potential of magnetic resonance (MR) metabolomics for study of preeclampsia, for improved phenotyping and elucidating potential clues to etiology and pathogenesis. Methods Urine and serum ... -
Metabolomic Biomarkers of Preeclampsia: An NMR Protocol Development and Pilot Study
(Master thesis, 2012)Preeclampsia is a serious complication of pregnancy, which presents risk to both the expectant mother and to the fetus. It affects 3-8% of pregnancies, resolves only upon delivery, and is a major cause of preterm birth. ... -
Metabolomics identifies placental dysfunction and confirms Flt-1 (FMS-like tyrosine kinase receptor 1) biomarker specificity
(Journal article; Peer reviewed, 2019)Clinical end-stage parameters define the pregnancy disorders preeclampsia and fetal growth restriction while classification of the underlying placental dysfunction is missing and urgently needed. Flt-1 (FMS-like tyrosine ... -
Metacognitions are associated with subjective memory problems in individuals on sick leave due to chronic fatigue
(Peer reviewed; Journal article, 2016)Background: Subjective cognitive impairments are frequent, but poorly understood in patients with chronic fatigue. We hypothesized that maladaptive metacognitive beliefs at baseline were associated with baseline subjective ... -
Metacognitive Beliefs as Predictors of Return to Work After Intensive Return-to-Work Rehabilitation in Patients With Chronic Pain, Chronic Fatigue and Common Psychological Disorders: Results From a Prospective Trial
(Peer reviewed; Journal article, 2020)Background: Metacognitions are associated with work status, but no research has examined to what extent metacognitions before treatment and change in metacognitions following treatment predict return to work (RTW) ... -
Metal Artifact Reduction for Total Hip Replacement in MRI
(Master thesis, 2019)Projektets baggrund: Philips 1.5 T-scanneren gennemgik en hardware-og softwareopgradering. Under denne proces var nogle af protokollerne ikke blevet opgraderet. Den gyldne standard pseudotumor hofte protokol bestod af 4 ... -
Method for Designing Semantic Annotation of Sepsis Signs in Clinical Text
(Chapter, 2023)Annotated clinical text corpora are essential for machine learning studies that model and predict care processes and disease progression. However, few studies describe the necessary experimental design of the annotation ... -
MGMT Promoter Methylation Status Is Not Related to Histological or Radiological Features in IDH Wild-type Glioblastomas
(Peer reviewed; Journal article, 2020)O6-methylguanine DNA methyltransferase (MGMT) promoter methylation is an important favorable predictive marker in patients with glioblastoma (GBM). We hypothesized that MGMT status could be a surrogate marker of pretreatment ... -
MicroRNA as biomarkers in colorectal cancer
(Master thesis, 2016)Colorectal cancer (CRC) is one of the worlds leading causes of cancer-related deaths in both men and women. Nearly 1.4 million new cases were reported in 2012 and over half of the cases ended in death. High mortality rates ... -
microRNA-451a prevents activation of matrix metalloproteinases 2 and 9 in human cardiomyocytes during pathological stress stimulation.
(Peer reviewed; Journal article, 2019)Matrix metalloproteinases (MMP) are important for cardiac remodeling. Recently, microRNA (miR)-451a has been found to inhibit the expression of both MMP-2 and MMP-9 in human malignancies, but its role in cardiomyocytes has ...