• Loss-of-function genomic variants highlight potential therapeutic targets for cardiovascular disease 

      Nielsen, Jonas Bille; Rom, Oren; Surakka, Ida; Graham, Sarah E.; Zhou, Wei; Roychowdhury, Tanmoy; Fritsche, Lars; Gagliano Taliun, Sarah; Sidore, Carlo; Liu, Yuhao; Gabrielsen, Maiken Elvestad; Skogholt, Anne Heidi; Wolford, Brooke; Overton, William; Zhao, Ying; Chen, Jin; Zhang, He; Hornsby, Whitney E.; Acheampong, Akua; Grooms, Austen; Schaefer, Amanda; Zajac, Gregory J.M.; Villacorta, Luis; Zhang, Jifeng; Brumpton, Ben Michael; Løset, Mari; Rai, Vivek; Lundegaard, Pia R.; Olesen, Morten S.; Taylor, Kent D.; Palmer, Nicholette D.; Chen, Yii-Der; Choi, Seung Hoan; Lubitz, Steven A.; Ellinor, Patrick T.; Barnes, Kathleen C.; Daya, Michelle; Rafaels, Nicholas; Weiss, Scott T.; Lasky-Su, Jessica; Tracy, Russell P.; Vasan, Ramachandran S.; Cupples, L. Adrienne; Mathias, Rasika A.; Yanek, Lisa R.; Becker, Lewis; Holmen, Oddgeir Lingaas; Åsvold, Bjørn Olav; Willer, Christen; Hveem, Kristian (Peer reviewed; Journal article, 2020)
      Pharmaceutical drugs targeting dyslipidemia and cardiovascular disease (CVD) may increase the risk of fatty liver disease and other metabolic disorders. To identify potential novel CVD drug targets without these adverse ...
    • Low back pain: Prognostic and associated factors within a biopsychosocial framework 

      Nordstoga, Anne Lovise (Doctoral theses at NTNU;2020:100, Doctoral thesis, 2020)
      Korsryggsmerter: Prognostiske og assosierte faktorer innenfor et biopsykososialt rammeverk Korsryggsmerter er en av de ledende årsakene til nedsatt funksjon og arbeidsevne både i Norge og globalt, og fører til utstrakt ...
    • Low C-peptide together with a high glutamic acid decarboxylase autoantibody level predicts progression to insulin dependence in latent autoimmune diabetes in adults: The HUNT study 

      Sørgjerd, Elin P.; Åsvold, Bjørn O.; Grill, Valdemar (Journal article; Peer reviewed, 2021)
      Aim: To search for risk factors that could predict progression in latent autoimmune diabetes in adults (LADA) and compare them with those for type 2 diabetes. Materials and Methods: This study included 175 participants ...
    • Low free testosterone and prostate cancer risk: A collaborative analysis of 20 prospective studies 

      Watts, Eleanor L.; Appleby, Paul N.; Perez-Cornago, Aurora; Bueno-De-Mesquita, Hendrik Bastiaan; Chan, June M.; Chen, Chu; Cohn, Barbara A.; Cook, Michael B.; Flicker, Leon; Freedman, Neal D.; Giles, Graham G.; Giovannucci, Edward; Gislefoss, Randi Elin; Hankey, Graeme J.; Kaaks, Rudolf; Knekt, Paul; Kolonel, Laurence N.; Kubo, Tatsuhiko; Le Marchand, Loïc; Luben, Robert N.; Luostarinen, Tapio; Männistö, Satu; Metter, E. Jeffrey; Mikami, Kazuya; Milne, Roger L.; Ozasa, Kotaro; Platz, Elizabeth A.; Quirós, José Ramón; Rissanen, Harri; Sawada, Norie; Stampfer, Meir; Stanczyk, Frank Z.; Stattin, Pär; Tamakoshi, Akiko; Tangen, Catherine M.; Thompson, Ian M.; Tsilidis, Konstantinos K.; Tsugane, Shoichiro; Ursin, Giske; Vatten, Lars Johan; Weiss, Noel S.; Yeap, Bu B.; Allen, Naomi E.; Key, Timothy J.; Travis, Ruth C. (Journal article; Peer reviewed, 2018)
      Background Experimental and clinical evidence implicates testosterone in the aetiology of prostate cancer. Variation across the normal range of circulating free testosterone concentrations may not lead to changes in ...
    • Low grade albuminuria as a risk factor for subtypes of stroke - the HUNT Study in Norway 

      Horn, Jens; Romundstad, Solfrid; Ellekjær, Hanne; Janszky, Imre; Horn, Julie (Peer reviewed; Journal article, 2020)
      Background and purpose Albuminuria is a marker for endothelial dysfunction and knowledge on its association with stroke and stroke subtypes are limited. Methods Corresponding data from 7261 participants of the ...
    • Low maternal microbiota sharing across gut, breast milk and vagina, as revealed by 16s rRNA gene and reduced metagenomic sequencing 

      Avershina, Ekaterina; Angell, Inga Leena; Simpson, Melanie Rae; Storrø, Ola; Øien, Torbjørn; Johnsen, Roar; Rudi, Knut (Journal article; Peer reviewed, 2018)
      The maternal microbiota plays an important role in infant gut colonization. In this work we have investigated which bacterial species are shared across the breast milk, vaginal and stool microbiotas of 109 women shortly ...
    • Low Serum Levels of 25-Hydroxyvitamin D Predict Hip Fracture in the Elderly: A NOREPOS Study 

      Holvik, Kristin; Ahmed, Luai Awad; Forsmo, Siri; Gjesdal, Clara Gram; Grimnes, Guri; Samuelsen, Sven Ove; Schei, Berit; Blomhoff, Rune; Tell, Grethe S; Meyer, Haakon E (Journal article; Peer reviewed, 2013)
      Background: Despite considerable interest, the relationship between circulating 25-hydroxyvitamin D and the risk of hip fracture is not fully established. Objective: The objective of the study was to study the association ...
    • Low thyroid function is not associated with an accelerated deterioration in renal function 

      Meuwese, Christiaan L.; van Diepen, Merel; Cappola, Anne R.; Sarnak, Mark J.; Shlipak, Michael G.; Bauer, Douglas C.; Fried, Linda P.; Iacoviello, Massimo; Vaes, Bert; Degryse, Jean; Khaw, Kay-Tee; Luben, Robert N.; Åsvold, Bjørn Olav; Bjøro, Trine; Vatten, Lars Johan; de Craen, Anton J.M.; Trompet, Stella; Iervasi, Giorgio; Molinaro, Sabrina; Ceresini, Graziano; Ferrucci, Luigi; Dullaart, Robin P.F.; Bakker, Stephan J.L.; Jukema, J. Wouter; Kearney, Patricia M.; Stott, David J.; Peeters, Robin P.; Franco, Oscar H.; Völzke, Henry; Walsh, John P.; Bremner, Alexandra; Sgarbi, José A.; Maciel, Rui M.B.; Imaizumi, Misa; Ohishi, Waka; Dekker, Friedo W.; Rodondi, Nicolas; Gussekloo, Jacobijn; den Elzen, Wendy P.J. (Peer reviewed; Journal article, 2019)
      Background Chronic kidney disease (CKD) is frequently accompanied by thyroid hormone dysfunction. It is currently unclear whether these alterations are the cause or consequence of CKD. This study aimed at studying the ...
    • Lower levels of physical activity volume are beneficial, and it’s never too late to start: Results from the HUNT Study, Norway 

      Breidablik, Hans Johan; Hufthammer, Karl Ove; Rangul, Vegar; Andersen, John Roger; Meland, Eivind; Hetlevik, Øystein; Vie, Tina Løkke (Peer reviewed; Journal article, 2023)
      Aims: We aimed to explore (a) how different patterns of physical activity (PA) over time (36 years) were associated with all-cause and cause-specific mortality, (b) if the association was similar for males and females and ...
    • Lower regulatory frequency for postural control in patients with fibromyalgia and chronic fatigue syndrome 

      Rasouli, Omid; Vasseljen, Ottar; Fors, Egil A; Lorås, Håvard; Stensdotter, Ann-Katrin (Journal article; Peer reviewed, 2018)
      As many similar symptoms are reported in fibromyalgia (FM) and chronic fatigue syndrome (CFS), underlying defcits may potentially also be similar. Postural disequilibrium reported in both conditions may thus be explained ...
    • Lowering of Circulating Sclerostin May Increase Risk of Atherosclerosis and its Risk Factors: Evidence From a Genome-Wide Association Meta-Analysis Followed by Mendelian Randomization 

      Zheng, Jie; Wheeler, Eleanor; Pietzner, Maik; Andlauer, Till F.M.; Yau, Michelle S.; Hartley, April E.; Brumpton, Ben Michael; Rasheed, Humaira; Kemp, John P.; Frysz, Monika; Robinson, Jamie; Reppe, Sjur; Prijatelj, Vid; Gautvik, Kaare M; Falk, Louise; Maerz, Winfried; Gergei, Ingrid; Peyser, Patricia A; Kavousi, Maryam; de Vries, Paul S.; Miller, Clint L.; Bos, Maxime; Van Der Laan, Sander W.; Malhotra, Rajeev; Herrmann, Markus; Scharnagl, Hubert; Kleber, Marcus; Dedoussis, George; Zeggini, Eleftheria; Nethander, Maria; Ohlsson, Claes; Lorentzon, Mattias; Wareham, Nick; Langenberg, Claudia; Holmes, Michael V.; Smith, George Davey; Tobias, Jonathan H. (Peer reviewed; Journal article, 2023)
      Objective In this study, we aimed to establish the causal effects of lowering sclerostin, target of the antiosteoporosis drug romosozumab, on atherosclerosis and its risk factors. Methods A genome-wide association ...
    • Lung cancer risk discrimination of prediagnostic proteomics measurements compared with existing prediction tools 

      Feng, Xiaoshuang; Wu, Wendy Yi-Ying; Onwuka, Justina Ucheojor; Haider, Zahra; Alcala, Karine; Smith-Byrne, Karl; Zahed, Hana; Guida, Florence; Wang, Renwei; Bassett, Julie K.; Stevens, Victoria; Wang, Ying; Weinstein, Stephanie; Freedman, Neal D.; Chen, Chu; Tinker, Lesley; Nøst, Therese Haugdahl; Koh, Woon-Puay; Muller, David; Colorado-Yohar, Sandra M.; Tumino, Rosario; Hung, Rayjean J.; Amos, Christopher I.; Lin, Xihong; Zhang, Xuehong; Arslan, Alan A.; Sánchez, Maria-Jose; Sørgjerd, Elin Pettersen; Severi, Gianluca; Hveem, Kristian; Brennan, Paul; Langhammer, Arnulf; Milne, Roger L.; Yuan, Jian-Min; Melin, Beatrice; Johansson, Mikael; Robbins, Hilary A.; Johansson, Mattias (Peer reviewed; Journal article, 2023)
      Background We sought to develop a proteomics-based risk model for lung cancer and evaluate its risk-discriminatory performance in comparison with a smoking-based risk model (PLCOm2012) and a commercially available ...
    • Lung function and peak oxygen uptake in chronic obstructive pulmonary disease phenotypes with and without emphysema 

      Rasch-Halvorsen, Øystein; Steinshamn, Sigurd Loe; Langhammer, Arnulf; Hassel, Erlend; Brumpton, Ben Michael; Jenssen, Haldor; Spruit, Martijn A. (Journal article; Peer reviewed, 2021)
      Previous studies of associations of forced expiratory lung volume in one second (FEV1) with peak oxygen uptake (VO2peak) in chronic obstructive pulmonary disease (COPD) have not taken sex, age and height related variance ...
    • Lykkelig ulykkelig fødsel 

      Ditlevsen, Rikke Adelén (Bachelor thesis, 2020)
      Tittel: Lykkelig ulykkelig fødsel Problemstilling: Hvordan kan sykepleier, på barselavdeling, oppdage tidlige tegn på fødselsdepresjon og forebygge videre utvikling av den? Hensikt: Innhente informasjon rundt risikofaktorer ...
    • Læring og kompetanseutvikling i kommunehelsetenesta - ein intervjustudie av kreftsjukepleiarar 

      Hynne, Astrid Bjørnerheim; Kvangarsnes, Marit (Journal article; Peer reviewed, 2014)
      Learning and competence development in community health service – an interview study of cancer nurses The number of cancer patients is expected to increase 30% by 2020. To meet the needs of seriously ill and dying cancer ...
    • A Machine Learning Classifier for Detection of Physical Activity Types and Postures During Free-Living 

      Bach, Kerstin; Kongsvold, Atle Austnes; Bårdstu, Hilde Bremseth; Bardal, Ellen Marie; Kjærnli, Håkon Slåtten; Herland, Sverre; Logacjov, Aleksej; Mork, Paul Jarle (Journal article; Peer reviewed, 2021)
      Accelerometer-based measurements of physical activity types are commonly used to replace self-reports. To advance the field, it is desirable that such measurements allow accurate detection of key daily physical activity ...
    • Major faecal microbiota shifts in composition and diversity with age in a geographically restricted cohort of mothers and their children 

      Avershina, Ekaterina; Storrø, Ola; Øien, Torbjørn; Johnsen, Roar; Pope, Phil; Rudi, Knut (Journal article; Peer reviewed, 2014)
      Despite the importance, the diversity of the human infant gut microbiota still remains poorly characterized at the regional scale. Here, we investigated the faecal microbiota diversity in a large 16S rRNA gene data set ...
    • Making and Maintaining Lifestyle Changes after Participating in Group Based Type 2 Diabetes Self-Management Educations: A Qualitative Study 

      Rise, Marit By; Pellerud, Anneli; Rygg, Lisbeth Østgaard; Steinsbekk, Aslak (Journal article; Peer reviewed, 2013)
      Background: Disease management is crucial in type 2 diabetes. Diabetes self-management education aims to provide the knowledge necessary to make and maintain lifestyle changes. However, few studies have investigated ...
    • Making Neglect Invisible: A Qualitative Study among Nursing Home Staff in Norway 

      Lund, Stine Borgen; Skolbekken, John-Arne; Mosqueda, Laura; Malmedal, Wenche Karin (Peer reviewed; Journal article, 2023)
      Background: Research shows that nursing home residents’ basic care needs are often neglected, potentially resulting in incidents that threaten patients’ safety and quality of care. Nursing staff are at the frontline for ...
    • Making sense of transdisciplinarity: Interpreting science policy in a biotechnology centre 

      Hesjedal, Maria Bårdsen; Åm, Heidrun (Peer reviewed; Journal article, 2022)
      Transdisciplinarity is a much-used concept in research policy to emphasize a need for new collaborations beyond scientific disciplines to solve societal challenges. However, how do scientists interpret transdisciplinarity ...