Institutt for klinisk og molekylær medisin
Nye registreringer
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Can ultrasound predict labor outcome in operative vaginal deliveries?
(Doctoral theses at NTNU;2020:183, Doctoral thesis, 2020) -
Relationship of estimated GFR and albuminuria to concurrent laboratory abnormalities: An individual participant data meta-analysis in a global consortium
(Peer reviewed; Journal article, 2018)Rationale & Objective Chronic kidney disease (CKD) is complicated by abnormalities that reflect disruption in filtration, tubular, and endocrine functions of the kidney. Our aim was to explore the relationship of specific ... -
CausalTAB: the PSI-MITAB 2.8 updated format for signalling data representation and dissemination
(Peer reviewed; Journal article, 2019)Motivation Combining multiple layers of information underlying biological complexity into a structured framework represent a challenge in systems biology. A key task is the formalization of such information in models ... -
Screening for frailty among older patients with cancer using blood biomarkers of inflammation
(Peer reviewed; Journal article, 2018)As frailty is associated with inflammation, biomarkers of inflammation may represent objective measures that could facilitate the identification of frailty. Glasgow prognostic score (GPS), combines C-reactive protein (CRP) ... -
Placental inflammation by HMGB1 activation of TLR4 at the syncytium
(Peer reviewed; Journal article, 2018)Normal pregnancy is characterized by an elevated inflammatory state involving the placenta. The placental inflammation is further increased in preeclampsia, resulting in release of harmful danger signals to the maternal ... -
On the prognostic factors of low-grade gliomas
(Doctoral theses at NTNU;2020:139, Doctoral thesis, 2020)Hjernesvulsters egenskaper i forløpet ved hjernekreft Gliomer er den vanligste typen av primære maligne hjernesvulster og disse rammer ca. 6 personer per 100 000 per år. Gliomer graderes ved mikroskopisk cellebilde og ... -
Tissue microstructure is linked to MRI parameters and metabolite levels in prostate cancer
(Peer reviewed; Journal article, 2016)Introduction: Magnetic resonance imaging (MRI) can portray spatial variations in tumor heterogeneity, architecture, and its microenvironment in a non-destructive way. The objective of this study was to assess the relationship ... -
Prognostic role of microscopically positive margins for primary gastrointestinal stromal tumors: a systematic review and meta-analysis
(Peer reviewed; Journal article, 2016)The impact and management of microscopically positive margins in gastrointestinal stromal tumors (GISTs) remain unclear. The aim of this study is to estimate the prognostic value of surgical margins for disease-free survival ... -
Fully Integrated Oncology and Palliative Care Services at a Local Hospital in Mid-Norway: Development and Operation of an Innovative Care Delivery Model
(Peer reviewed; Journal article, 2020)Introduction Early access to cancer palliative care is recommended. Descriptions of structures and processes of outpatient palliative care clinics operated within smaller hospitals are scarce. This paper presents the ... -
Hemoglobin A1c as screening for gestational diabetes mellitus in Nordic Caucasian women
(Peer reviewed; Journal article, 2016)Background Gestational diabetes mellitus (GDM) increases the risk for preeclampsia and macrosomia. GDM is conventionally diagnosed by an oral glucose tolerance test (OGTT). Hemoglobin A1c (HbA1c) is a marker for the ... -
Genetic variation and cognitive dysfunction in opioid-treated patients with cancer
(Peer reviewed; Journal article, 2016)Background and purpose The effects of single‐nucleotide polymorphisms (SNPs) on the cognitive function of opioid‐treated patients with cancer until now have not been explored, but they could potentially be related to ... -
Learning the effects of psychotropic drugs during pregnancy using real-world safety data: a paradigm shift toward modern pharmacovigilance
(Peer reviewed; Journal article, 2018)The growing evidence on psychotropic drug safety in pregnancy has been possible thanks to the increasing availability of real-world data, i.e. data not collected in conventional randomised controlled trials. Use of these ... -
TopoICSim: A new semantic similarity measure based on gene ontology
(Peer reviewed; Journal article, 2016)Background The Gene Ontology (GO) is a dynamic, controlled vocabulary that describes the cellular function of genes and proteins according to tree major categories: biological process, molecular function and cellular ... -
Investigating optimal β-cell-preserving treatment in latent autoimmune diabetes in adults: Results from a 21-month randomized trial
(Peer reviewed; Journal article, 2019)Aims To compare outcomes of glucagon‐stimulated C‐peptide tests (GSCTs) in people with latent autoimmune diabetes in adults (LADA) after a 21‐month intervention with either insulin or the dipeptidyl peptidase‐4 inhibitor ... -
Molecular Features of Subtype-Specific Progression from Ductal Carcinoma In Situ to Invasive Breast Cancer
(Peer reviewed; Journal article, 2016)Breast cancer consists of at least five main molecular “intrinsic” subtypes that are reflected in both pre-invasive and invasive disease. Although previous studies have suggested that many of the molecular features of ... -
The human RAD5 homologs, HLTF and SHPRH, have separate functions in DNA damage tolerance dependent on the DNA lesion type
(Peer reviewed; Journal article, 2020)Helicase-like transcription factor (HLTF) and SNF2, histone-linker, PHD and RING finger domain-containing helicase (SHPRH), the two human homologs of yeast Rad5, are believed to have a vital role in DNA damage tolerance ... -
Genome-wide association study identifies multiple susceptibility loci for multiple myeloma
(Peer reviewed; Journal article, 2016)Multiple myeloma (MM) is a plasma cell malignancy with a significant heritable basis. Genome-wide association studies have transformed our understanding of MM predisposition, but individual studies have had limited power ... -
Feature-based classification of human transcription factors into hypothetical sub-classes related to regulatory function.
(Peer reviewed; Journal article, 2016)Background Transcription factors are key proteins in the regulation of gene transcription. An important step in this process is the opening of chromatin in order to make genomic regions available for transcription. Data ... -
New players in an old game: Role of immunoglobulins in the pathogenesis of multiple myeloma
(Doctoral theses at NTNU;2020:124, Doctoral thesis, 2020)Multiple myeloma is a haematological malignancy characterized by uncontrolled proliferation of malignant plasma cells. The myeloma cells secrete immunoglobulins, which leads to the presence of high levels of monoclonal ... -
Pathway Analysis of Skin from Psoriasis Patients after Adalimumab Treatment Reveals New Early Events in the Anti-Inflammatory Mechanism of Anti-TNF-α
(Peer reviewed; Journal article, 2016)Psoriasis is a chronic cutaneous inflammatory disease. The immunopathogenesis is a complex interplay between T cells, dendritic cells and the epidermis in which T cells and dendritic cells maintain skin inflammation. ...
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