Blar i Institutt for klinisk og molekylær medisin på tidsskrift "eLIFE"

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    • 53BP1 and BRCA1 control pathway choice for stalled replication restart 

      Xu, Yixi; Ning, Shaokai; Wei, Zheng; Xu, Ran; Xu, Xinlin; Xing, Mengtan; Guo, Rong; Xu, Dongyi (Journal article; Peer reviewed, 2017)
      The cellular pathways that restart stalled replication forks are essential for genome stability and tumor prevention. However, how many of these pathways exist in cells and how these pathways are selectively activated ...

    • The allosteric modulation of complement c5 by knob domain peptides 

      Macpherson, Alex; Laabei, Maisem; Ahdash, Zainab; Graewert, Melissa Ann; Birtley, James R.; Schulze, Monika-Sarah E.D.; Crennell, Susan; Robinson, Sarah A.; Holmes, Ben; Oleinikovas, Vladas; Nilsson, Per H.; Snowden, James; Ellis, Victoria; Mollnes, Tom Eirik; Deane, Charlotte M.; Svergun, Dmitri I.; Lawson, Alastair D.G.; van den Elsen, Jean (Peer reviewed; Journal article, 2021)
      Bovines have evolved a subset of antibodies with ultra-long heavy chain complementarity determining regions that harbour cysteine-rich knob domains. To produce high-affinity peptides, we previously isolated autonomous 3–6 ...

    • Ascorbic acid supports ex vivo generation of plasmacytoid dendritic cells from circulating hematopoietic stem cells 

      Laustsen, Anders; van der Sluis, Renée M.; Gris-Oliver, Albert; Hernández, Sabina Sánchez; Cemalovic, Ena; Tang, Hai Q.; Pedersen, Lars Henning; Uldbjerg, Niels; Jakobsen, Martin R.; Bak, Rasmus O. (Peer reviewed; Journal article, 2021)
      Plasmacytoid dendritic cells (pDCs) constitute a rare type of immune cell with multifaceted functions, but their potential use as a cell-based immunotherapy is challenged by the scarce cell numbers that can be extracted ...

    • Glycine inhibits NINJ1 membrane clustering to suppress plasma membrane rupture in cell death 

      Borges, Jazlyn P.; Sætra, Ragnhild Sofie Ragnhildstveit; Volchuk, Allen; Bugge, Marit; Devant, Pascal; Sporsheim, Bjørnar; Kilburn, Bridget R.; Evavold, Charles L.; Kagan, Jonathan C.; Goldenberg, Neil M.; Flo, Trude Helen; Steinberg, Benjamin Ethan (Peer reviewed; Journal article, 2022)
      First recognized more than 30 years ago, glycine protects cells against rupture from diverse types of injury. This robust and widely observed effect has been speculated to target a late downstream process common to multiple ...

    • Impaired astrocytic Ca2+ signaling in awake-behaving Alzheimer’s disease transgenic mice 

      Åbjørsbråten, Knut Sindre; Skaaraas, Gry HE Syverstad; Cunen, Celine Marie Løken; Bjørnstad, Daniel Marelius; Binder, Kristin M Gullestad; Bojarskaite, Laura; Jensen, Vidar; Nilsson, Lars; Rao, Shreyas B.; Tang, Wannan; Hermansen, Gudmund Horn; Nagelhus, Erlend Arnulf; Ottersen, Ole Petter; Torp, Reidun; Enger, Rune (Peer reviewed; Journal article, 2022)
      Increased astrocytic Ca2+ signaling has been shown in Alzheimer’s disease mouse models, but to date no reports have characterized behaviorally induced astrocytic Ca2+ signaling in such mice. Here, we employ an event-based ...

    • Lactate receptor HCAR1 regulates neurogenesis and microglia activation after neonatal hypoxia-ischemia 

      Kennedy, Lauritz Hagen; Glesaaen, Emilie Rylund; Palibrk, Vuk; Pannone, Marco; Wang, Wei; Al-Jabri, Ali; Suganthan, Rajikala; Meyer, Niklas; Austbø, Marie Landa; Lin, Xiaolin; Bergersen, Linda Hildegard; Bjørås, Magnar; Rinholm, Johanne Egge (Peer reviewed; Journal article, 2022)
      Neonatal cerebral hypoxia-ischemia (HI) is the leading cause of death and disability in newborns with the only current treatment being hypothermia. An increased understanding of the pathways that facilitate tissue repair ...

    • Novel analytical tools reveal that local synchronization of cilia coincides with tissue-scale metachronal waves in zebrafish multiciliated epithelia 

      Ringers, Christa Nelleke; Bialonski, Stephan; Ege, Mert; Solovev, Anton; Hansen, Jan; Jeong, Inyoung; Friedrich, Benjamin; Jurisch-Yaksi, Nathalie (Journal article; Peer reviewed, 2023)

    • Origin and role of the cerebrospinal fluid bidirectional flow in the central canal 

      Thouvenin, Olivier; Keiser, Ludovic; Cantaut-Belarif, Yasmine; Carbo-Tano, Martin; Verweij, Frederik J.; Jurisch-Yaksi, Nathalie; Bardet, Pierre-Luc; Van Niel, Guillaume; Gallaire, Francois; Wyart, Claire (Peer reviewed; Journal article, 2020)
      Circulation of the cerebrospinal fluid (CSF) contributes to body axis formation and brain development. Here, we investigated the unexplained origins of the CSF flow bidirectionality in the central canal of the spinal cord ...

    • Soluble collectin-12 mediates C3-independent docking of properdin that activates the alternative pathway of complement 

      Zhang, Jie; Song, Lihong; Pedersen, Dennis V.; Li, Anna; Lambris, John D.; Andersen, Gregers Rom; Mollnes, Tom Eirik; Ma, Ying Jie; Garred, Peter (Peer reviewed; Journal article, 2020)
      Properdin stabilizes the alternative C3 convertase (C3bBb), whereas its role as pattern-recognition molecule mediating complement activation is disputed for decades. Previously, we have found that soluble collectin-12 ...

    • Unique-region phosphorylation targets LynA for rapid degradation, tuning its expression and signaling in myeloid cells 

      Brian, Ben F; Jolicoeur, Adrienne S; Guerrero, Candace R.; Nunez, Myra G; Sychev, Zoi E; Hegre, Siv Anita; Sætrom, Pål; Habib, Nagy; Drake, Justin M; Schwertfeger, Kathryn L; Freedman, Tanya S. (Journal article; Peer reviewed, 2019)
      The activity of Src-family kinases (SFKs), which phosphorylate immunoreceptor tyrosine-based activation motifs (ITAMs), is a critical factor regulating myeloid-cell activation. We reported previously that the SFK LynA is ...