Blar i Institutt for klinisk og molekylær medisin på tidsskrift "Science Advances"
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Functional properties of habenular neurons are determined by developmental stage and sequential neurogenesis
(Peer reviewed; Journal article, 2020)The developing brain undergoes drastic alterations. Here, we investigated developmental changes in the habenula, a brain region that mediates behavioral flexibility during learning, social interactions, and aversive ... -
LSD1 represses a neonatal/reparative gene program in adult intestinal epithelium
(Journal article; Peer reviewed, 2020)Intestinal epithelial homeostasis is maintained by adult intestinal stem cells, which, alongside Paneth cells, appear after birth in the neonatal period. We aimed to identify regulators of neonatal intestinal epithelial ... -
Mre11 exonuclease activity removes the chain-terminating nucleoside analog gemcitabine from the nascent strand during DNA replication
(Peer reviewed; Journal article, 2020)The Mre11 nuclease is involved in early responses to DNA damage, often mediated by its role in DNA end processing. MRE11 mutations and aberrant expression are associated with carcinogenesis and cancer treatment outcomes. ... -
Recapitulating hepatitis E virus-host interactions and facilitating antiviral drug discovery in human liver-derived organoids
(Peer reviewed; Journal article, 2022)Hepatotropic viruses naturally have narrow host and tissue tropisms, challenging the development of robust experimental models. The advent of organoid technology provides a unique opportunity for moving the field forward. ...