Blar i Institutt for klinisk og molekylær medisin på tidsskrift "Journal of Biological Chemistry"

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    • A role for the adaptor proteins TRAM and TRIF in toll-like receptor 2 signaling 

      Nilsen, Nadra; Gregory I., Vladimer; Stenvik, Jørgen; Ørning, Mathias Pontus; Zeid-Kilani, Maria Vanessa; Bugge, Marit; Bergstrøm, Bjarte; Conlon, Joseph; Husebye, Harald; Amy, Hise; Fitzgerald, Katherine A.; Espevik, Terje; Lien, Egil (Journal article; Peer reviewed, 2015)
      Toll-like receptors (TLRs) are involved in sensing invading microbes by host innate immunity. TLR2 recognizes bacterial lipoproteins/lipopeptides, and lipopolysaccharide activates TLR4. TLR2 and TLR4 signal via the ...

    • MutT homologue 1 (MTH1) removes N6-methyl-dATP from the dNTP pool 

      Scaletti, Emma Rose; Vallin, Karl S.A.; Bräutigam, Lars; Sarno, Antonio; Berglund, Ulrika Warpman; Helleday, Thomas; Stenmark, Pål; Jemth, Ann-Sofie (Peer reviewed; Journal article, 2020)
      MutT homologue 1 (MTH1) removes oxidized nucleotides from the nucleotide pool and thereby prevents their incorporation into the genome and thereby reduces genotoxicity. We previously reported that MTH1 is an efficient ...

    • Reversible and irreversible inhibitors of coronavirus Nsp15 endoribonuclease 

      Chen, Jerry; Farraj, Rabih Abou; Limonta, Daniel; Tabatabaei Dakhili, Seyed Amir; Kerek, Evan M.; Bhattacharya, Ashim; Reformat, Filip M.; Mabrouk, Ola M.; Brigant, Benjamin Romain; Pfeifer, Tom A.; McDermott, Mark T.; Ussher, John R.; Hobman, Tom C.; Glover, J.N. Mark; Hubbard, Basil P. (Peer reviewed; Journal article, 2023)
      The emergence of severe acute respiratory syndrome coronavirus 2, the causative agent of coronavirus disease 2019, has resulted in the largest pandemic in recent history. Current therapeutic strategies to mitigate this ...

    • Surface Toll-Like Receptor 3 Expression in Metastatic Intestinal Epithelial Cells induces Selective Cytokine Production and Promotes Invasiveness 

      Bugge, Marit; Bergstrøm, Bjarte; Oda Kamilla, Eide; Helene, Solli; Kjønstad, Ingrid F.; Stenvik, Jørgen; Espevik, Terje; Nilsen, Nadra J. (Journal article; Peer reviewed, 2017)
      Toll-like receptors (TLR)s are innate immune receptors for microbial molecules and also sense damage-associated molecular patterns released from host cells. Double-stranded RNA and the synthetic analog polyinosinic:polycytidylic ...