Blar i Institutt for klinisk og molekylær medisin på tidsskrift "Genes"

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    • APOE Polymorphism and Endocrine Functions in Subjects with Morbid Obesity Undergoing Bariatric Surgery 

      Farup, Per Grønaas; Jansen, Aina; Hestad, Knut; Aaseth, Jan; Rootwelt, Helge (Peer reviewed; Journal article, 2022)
      Background: Obesity is an interplay between genes and the environment, including lifestyle. The genetics of obesity is insufficiently understood. Apolipoprotein E (APOE) genetic polymorphism has been associated with a wide ...

    • APOE Polymorphism Is Associated with Changes in the Kynurenine Pathway 

      Farup, Per Grønaas; Rootwelt, Helge; Hestad, Knut (Peer reviewed; Journal article, 2023)
      Abstract: Background: APOE polymorphism and the Kynurenine pathway (KP) are associated with many disorders, but little is known about associations between APOE polymorphism and the KP. This study explored the associations ...

    • Functional Analyses of Rare Germline Missense BRCA1 Variants Located within and outside Protein Domains with Known Functions 

      Hovland, Henrikke Nilsen; Mchaina, Eunice Kabanyana; Vetti, Hildegunn Høberg; Ariansen, Sarah Louise; Sjursen, Wenche; Van Ghelue, Marijke; Haukanes, Bjørn Ivar; Knappskog, Per Morten; Aukrust, Ingvild; Berge, Elisabet Ognedal (Peer reviewed; Journal article, 2023)
      The BRCA1 protein is implicated in numerous important cellular processes to prevent genomic instability and tumorigenesis, and pathogenic germline variants predispose carriers to hereditary breast and ovarian cancer (HBOC). ...

    • Genetic Rescue of the Highly Inbred Norwegian Lundehund 

      Melis, Claudia; Pertoldi, Cino; Ludington, William Basil; Beuchat, Carol; Qvigstad, Gunnar; Stronen, Astrid Vik (Journal article; Peer reviewed, 2022)
      Augmenting the genetic diversity of small, inbred populations by the introduction of new individuals is often termed “genetic rescue“. An example is the Norwegian Lundehund, a small spitz dog with inbreeding-related health ...

    • PML regulates the epidermal differentiation complex and skin morphogenesis during mouse embryogenesis 

      Polec, Anna; Rowe, Alexander D.; Blicher, Pernille; Suganthan, Rajikala; Bjørås, Magnar; Bøe, Stig Ove (Peer reviewed; Journal article, 2020)
      The promyelocytic leukemia (PML) protein is an essential component of nuclear compartments called PML bodies. This protein participates in several cellular processes, including growth control, senescence, apoptosis, and ...