Blar i Institutt for klinisk og molekylær medisin på tidsskrift "Frontiers in Immunology"

Viser treff 1-20 av 47

    • Age and Sex-Associated Changes of Complement Activity and Complement Levels in a Healthy Caucasian Population 

      Gaya de Costa, Mariana; Poppelaars, Felix; van Kooten, Cees; Mollnes, Tom Eirik; Tedesco, Francesco; Würzner, Reinhard; Trouw, Leendert A.; Truedsson, Lennart; Daha, Mohamed R.; Roos, Anja; Seelen, Marc A. (Journal article; Peer reviewed, 2018)
      Introduction: The complement system is essential for an adequate immune response. Much attention has been given to the role of complement in disease. However, to better understand complement in pathology, it is crucial to ...

    • The Alternative Complement Pathway Is Activated Without a Corresponding Terminal Pathway Activation in Patients With Heart Failure 

      Shahini, Negar; Bjørkelund, Elisabeth; Bendz, Christina; Massey, Richard J; Schjalm, Camilla; Halvorsen, Bente; Broch, Kaspar; Ueland, Thor; Gullestad, Lars; Nilsson, Per H.; Aukrust, Pål; Mollnes, Tom Eirik; Louwe, Maria Cornelia (Journal article; Peer reviewed, 2021)
      Objective Dysregulation of the complement system has been described in patients with heart failure (HF). However, data on the alternative pathway are scarce and it is unknown if levels of factor B (FB) and the C3 convertase ...

    • Bystander memory T cells and IMiD/checkpoint therapy in multiple myeloma: A dangerous tango? 

      Sponaas, Anne-Marit; Waage, Anders; Vandsemb, Esten; Misund, Kristine; Børset, Magne; Sundan, Anders; Slørdahl, Tobias Schmidt; Standal, Therese (Peer reviewed; Journal article, 2021)
      In this review article we discuss the role of the memory T cells in multiple myeloma (MM) and how they may influence immune responses in patients that received immunomodulating drugs and check point therapy

    • Case Report: Limbic encephalitis following treatment with durvalumab for small-cell lung cancer 

      Moss, Thomas Totland; Stavem, Knut; Aandahl, Astrid; Gløersen, Anne S.; Grønberg, Bjørn Henning; Neumann, Kirill; Vedeler, Christian Alexander; Lundqvist, Christofer (Peer reviewed; Journal article, 2023)
      Background: Durvalumab is an immune checkpoint Inhibitor (ICIs) that is used in the treatment of malignant tumors, such as lung cancer and melanoma. ICIs are associated with immune-related adverse events including autoimmune ...

    • Cholesterol crystals and NLRP3 mediated inflammation in the uterine wall decidua in normal and preeclamptic pregnancies 

      Silva, Gabriela; Gierman, Lobke; Rakner, Johanne Johnsen; Stødle, Guro; Mundal, Siv Boon; Thaning, Astrid Josefin; Sporsheim, Bjørnar; Elschot, Mattijs; Collett, Karin; Bjørge, Line; Aune, Marie Hjelmseth; Thomsen, Liv Cecilie Vestrheim; Iversen, Ann-Charlotte (Peer reviewed; Journal article, 2020)
      Preeclampsia is a hypertensive and inflammatory pregnancy disorder associated with cholesterol accumulation and inflammation at the maternal-fetal interface. Preeclampsia can be complicated with fetal growth restriction ...

    • Circulating Levels of Anti-C1q and Anti-Factor H Autoantibodies and Their Targets in Normal Pregnancy and Preeclampsia 

      Dijkstra, Douwe Jan; Lokki, A Inkeri; Gierman, Lobke; Borggreven, Nicole Veronique; van der Keur, Carin; Eikmans, Michael; Gelderman, Kyra Andrea; Laivuori, Hannele; Heinonen, Seppo; Kajantie, Eero Olavi; Kere, Juha; Kivinen, Katja; Pouta, Anneli; Iversen, Ann-Charlotte; van der Hoorn, Marie-Louise P; Trouw, Leendert Adrianus (Peer reviewed; Journal article, 2022)
      Preeclampsia (PE) generally manifests in the second half of pregnancy with hypertension and proteinuria. The understanding of the origin and mechanism behind PE is incomplete, although there is clearly an immune component ...

    • Common nodes of virus–host interaction revealed through an integrated network analysis 

      Bösl, Korbinian; Ianevski, Aleksandr; Than, Thoa T.; Andersen, Petter I.; Kuivanen, Suvi; Teppor, Mona; Zusinaite, Eva; Dumpis, Uga; Vitkauskiene, Astra; Cox, Rebecca Jane; Kallio-Kokko, Hannimari; Bergqvist, Anders; Tenson, Tanel; Merits, Andres; Oksenych, Valentyn; Bjørås, Magnar; Anthonsen, Marit Walbye; Shum, David H.K.; Kaarbø, Mari; Vapalahti, Olli; Windisch, Marc P.; Superti-Furga, Giulio; Snijder, Berend; Kainov, Denis; Kandasamy, Richard Kumaran (Journal article; Peer reviewed, 2019)
      Viruses are one of the major causes of acute and chronic infectious diseases and thus a major contributor to the global burden of disease. Several studies have shown how viruses have evolved to hijack basic cellular pathways ...

    • Comparative Proteomic Analysis Reveals Varying Impact on Immune Responses in Phorbol 12-Myristate-13-Acetate-Mediated THP-1 Monocyte-to-Macrophage Differentiation 

      Pinto, Sneha M.; Kim, Hera; Subbannayya, Yashwanth; Giambelluca, Miriam S.; Bösl, Korbinian; Ryan, Liv; Sharma, Animesh; Kandasamy, Richard Kumaran (Journal article; Peer reviewed, 2021)
      Macrophages are sentinels of the innate immune system, and the human monocytic cell line THP-1 is one of the widely used in vitro models to study inflammatory processes and immune responses. Several monocyte-to-macrophage ...

    • Compartmentalization of Immune Response and Microbial Translocation in Decompensated Cirrhosis 

      Alvarez-Silva, Camila; Schierwagen, Robert; Pohlmann, Alessandra; Magdaleno, Fernando; Uschner, Frank Erhard; Ryan, Patrick; Vehreschild, Maria J. G. T.; Claria, Joan; Latz, Eicke; Lelouvier, Benjamin; Arumugam, Manimozhiyan; Trebicka, Jonel (Peer reviewed; Journal article, 2019)
      Background: Acquired dysfunctional immunity in cirrhosis predisposes patients to frequent bacterial infections, especially spontaneous bacterial peritonitis (SBP), leading to systemic inflammation that is associated with ...

    • Complement C3b contributes to Escherichia coli-induced platelet aggregation in human whole blood 

      Landsem, Anne; Emblem, Åse; Lau, Corinna; Christiansen, Dorte; Gerogianni, Alexandra; Karlsen, Bård Ove; Mollnes, Tom Eirik; Nilsson, Per; Brekke, Ole Lars (Journal article; Peer reviewed, 2022)

    • Complement Is Activated During Normothermic Machine Perfusion of Porcine and Human Discarded Kidneys 

      Jager, Neeltina M.; Venema, Leonie H.; Arykbaeva, Asel S.; Meter-Arkema, Anita H.; Ottens, Petra J.; van Kooten, Cees; Mollnes, Tom Eirik; Alwayn, Ian P. J.; Leuvenink, Henri G. D.; Pischke, Soeren (Peer reviewed; Journal article, 2022)
      Background: The gap between demand and supply of kidneys for transplantation necessitates the use of kidneys from extended criteria donors. Transplantation of these donor kidneys is associated with inferior results, reflected ...

    • Comprehensive protocols for culturing and molecular biological analysis of IBD patient-derived colon epithelial organoids 

      Gopalakrishnan, Shreya; Bakke, Ingunn; Hansen, Marianne Dore; Skovdahl, Helene Kolstad; Granlund, Atle van Beelen; Sandvik, Arne Kristian; Bruland, Torunn (Journal article; Peer reviewed, 2023)

    • Cytokine Patterns in Maternal Serum From First Trimester to Term and Beyond 

      Jarmund, Anders Hagen; Giskeødegård, Guro F.; Ryssdal, Mariell; Steinkjer, Bjørg; Stokkeland, Live Marie; Madssen, Torfinn Støve; Stafne, Signe Nilssen; Stridsklev, Solhild; Moholdt, Trine; Heimstad, Runa Kristine; Vanky, Eszter; Iversen, Ann-Charlotte (Peer reviewed; Journal article, 2021)
      Pregnancy implies delicate immunological balance between two individuals, with constant changes and adaptions in response to maternal capacity and fetal demands. We performed cytokine profiling of 1149 longitudinal serum ...

    • Elevated Terminal C5b-9 Complement Complex 10 Weeks Post Kidney Transplantation Was Associated With Reduced Long-Term Patient and Kidney Graft Survival 

      Witczak, Bartlomiej J; Pischke, Søren E.; Reisæter, Anna V.; Midtvedt, Karsten; Ludviksen, Judith K; Heldal, Kristian; Jenssen, Trond; Hartmann, Anders; Åsberg, Anders; Mollnes, Tom E. (Peer reviewed; Journal article, 2021)
      Background: The major reason for graft loss is chronic tissue damage, as interstitial fibrosis and tubular atrophy (IF/TA), where complement activation may serve as a mediator. The association of complement activation in ...

    • Generation and Functional In Vitro Analysis of Semliki Forest Virus Vectors Encoding TNF-α and IFN-γ 

      Kurena, Baiba; Müller, Elisabeth; Christopoulos, Panagiotis; Johnsen, Ingvild Bjellmo; Stankovic, Branislava; Øynebråten, Inger; Corthay, Alexandre; Zajakina, Anna (Journal article; Peer reviewed, 2017)
      Cytokine gene delivery by viral vectors is a promising novel strategy for cancer immunotherapy. Semliki Forest virus (SFV) has many advantages as a delivery vector, including the ability to (i) induce p53-independent killing ...

    • Gut microbiota-dependent trimethylamine N-oxide associates with inflammation in common variable immunodeficiency 

      Macpherson, Magnhild Eide; Hov, Johannes Espolin Roksund; Ueland, Thor; Dahl, Tuva Børresdatter; Kummen, Martin; Otterdal, Kari; Holm, Kristian; Berge, Rolf Kristian; Mollnes, Tom Eirik; Trøseid, Marius; Halvorsen, Bente; Aukrust, Pål; Fevang, Børre; Jørgensen, Silje Fjellgård (Peer reviewed; Journal article, 2020)
      A substantial proportion of patients with common variable immunodeficiency (CVID) have inflammatory and autoimmune complications of unknown etiology. We have previously shown that systemic inflammation in CVID correlates ...

    • Heme Interferes With Complement Factor I-Dependent Regulation by Enhancing Alternative Pathway Activation 

      Gerogianni, Alexandra; Dimitrov, Jordan D.; Zarantonello, Alessandra; Poillerat, Victoria; Chonat, Satheesh; Sandholm, Kerstin; McAdam, Karin E.; Ekdahl, Kristina N.; Mollnes, Tom Eirik; Mohlin, Camilla; Roumenina, Lubka T.; Nilsson, Per (Peer reviewed; Journal article, 2022)
      Hemolysis, as a result of disease or exposure to biomaterials, is characterized by excess amounts of cell-free heme intravascularly and consumption of the protective heme-scavenger proteins in plasma. The liberation of ...

    • High aspect ratio nanomaterial-induced macrophage polarization is mediated by changes in miRNA levels 

      Erdem, Johanna Samulin; Závodná, Táňa; Ervik, Torunn Kringlen; Skare, Øivind; Hron, Tomáš; Anmarkrud, Kristine H.; Kuśnierczyk, Anna; Catalán, Julia; Ellingsen, Dag; Topinka, Jan; Zienolddiny-Narui, Shanbeh (Peer reviewed; Journal article, 2023)
      Introduction: Inhalation of nanomaterials may induce inflammation in the lung which if left unresolved can manifest in pulmonary fibrosis. In these processes, alveolar macrophages have an essential role and timely modulation ...

    • Human metapneumovirus driven IFN-β production antagonizes macrophage transcriptional induction of IL1-β in response to bacterial pathogens 

      Loevenich, Simon; Montaldo, Nicola Pietro; Wickenhagen, Arthur; Sherstova, Tatyana; van Loon, Barbara; Boyartchuk, Victor; Anthonsen, Marit Walbye (Journal article; Peer reviewed, 2023)

    • Human Metapneumovirus Induces IRF1 via TANK-Binding Kinase 1 and Type I IFN 

      Loevenich, Simon; Spahn, Alix Saskia; Rian, Kristin; Boyartchuk, Victor; Anthonsen, Marit Walbye (Peer reviewed; Journal article, 2021)
      The innate immune and host-protective responses to viruses, such as the airway pathogen human metapneumovirus (HMPV), depend on interferons (IFNs) that is induced through TANK-binding kinase 1 (TBK1) and IFN regulatory ...