Blar i Institutt for klinisk og molekylær medisin på tidsskrift "EBioMedicine"

Viser treff 1-7 av 7

    • A Validated Clinical Risk Prediction Model for Lung Cancer in Smokers of All Ages and Exposure Types: A HUNT Study 

      Markaki, Maria Dorothea Haaberg; Tsamardinos, Ioannis; Langhammer, Arnulf; Lagani, Vincenzo; Hveem, Kristian; Røe, Oluf Dimitri (Journal article; Peer reviewed, 2018)
      Lung cancer causes >1·6 million deaths annually, with early diagnosis being paramount to effective treatment. Here we present a validated risk assessment model for lung cancer screening. The prospective HUNT2 population ...

    • Cholesterol crystals use complement to increase NLRP3 signaling pathways in coronary and carotid atherosclerosis 

      Niyonzima, Nathalie; Bakke, Siril S.; Gregersen, Ida; Holm, Sverre; Sandanger, Øystein; Orrem, Hilde Lang; Sporsheim, Bjørnar; Ryan, Liv; Kong, Xiang Yi; Dahl, Tuva Børresdatter; Skjelland, Mona; Sørensen, Kirsten; Rokstad, Anne Mari A.; Yndestad, Arne; Latz, Eicke; Gullestad, Lars; Andersen, Geir Øystein; Damås, Jan Kristian; Aukrust, Pål; Mollnes, Tom Eirik; Halvorsen, Bente; Espevik, Terje (Peer reviewed; Journal article, 2020)
      Background: During atherogenesis, cholesterol precipitates into cholesterol crystals (CC) in the vessel wall, which trigger plaque inflammation by activating the NACHT, LRR and PYD domains-containing protein 3 (NLRP3) ...

    • Fetal HLA-G mediated immune tolerance and interferon response in preeclampsia 

      Wedenoja, Satu; Yoshihara, Masahito; Teder, Hindrek; Sariola, Hannu; Gissler, Mika; Katayama, Shintaro; Wedenoja, Juho; Häkkinen, Inka M.; Ezer, Sini; Linder, Nina; Lundin, Johan; Skoog, Tiina; Sahlin, Ellika; Iwarsson, Erik; Pettersson, Karin; Kajantie, Eero Olavi; Mokkonen, Mikael; Heinonen, Seppo; Laivuori, Hannele; Krjutškov, Kaarel; Kere, Juha (Peer reviewed; Journal article, 2020)
      Background Fetal immune tolerance is crucial for pregnancy success. We studied the link between preeclampsia, a severe pregnancy disorder with uncertain pathogenesis, and fetal human leukocyte antigen G (HLA-G) and other ...

    • Interleukin-6 inhibition in ST-elevation myocardial infarction: Immune cell profile in the randomised ASSAIL-MI trial 

      Huse, Camilla; Anstensrud, Anne Kristine; Michelsen, Annika Elisabet; Ueland, Thor; Broch, Kaspar; Woxholt, Sindre; Yang, Kuan; Sharma, Kapil Kishore; Tøllefsen, Ingvild Maria; Bendz, Bjørn; Amundsen, Brage H.; Damås, Jan Kristian; Berg, Erlend Sturle; Bjørkelund, Elisabeth; Quiles-Jiménez, Ana M T; Bjerkeli, Vigdis; Bendz, Christina; Kleveland, Ola; Stensæth, Knut Haakon; Opdahl, Anders; Kløw, Nils-Einar; Andersen, Geir Øystein; Wiseth, Rune; Halvorsen, Bente; Gullestad, Lars; Seljeflot, Ingebjørg; Aukrust, Pål; Osnes, Liv T. N.; Dahl, Tuva Børresdatter (Peer reviewed; Journal article, 2022)
      We recently showed that interleukin (IL)-6 inhibition by tocilizumab improves myocardial salvage in ST-elevation myocardial infarction (STEMI). However, the mechanisms for this effect are not clear. Methods In this ...

    • Metabolomics and Gene Expression Analysis Reveal Down-regulation of the Citric Acid (TCA) Cycle in Non-diabetic CKD Patients 

      Hallan, Stein; Afkarian, Maryam; Zelnick, Leila R.; Kestenbaum, Bryan; Sharma, Shoba; Saito, Rintaro; Darshi, Manjula; Barding, Gregory; Raftery, Daniel; Ju, Wenjun; Kretzler, Matthias; Sharma, Kumar; de Boer, Ian H. (Journal article; Peer reviewed, 2017)
      Chronic kidney disease (CKD) is a public health problem with very high prevalence and mortality. Yet, there is a paucity of effective treatment options, partly due to insufficient knowledge of underlying pathophysiology. ...

    • PYY Plays a Key Role in the Resolution of Diabetes Following Bariatric Surgery in Humans 

      Chen, Duan; Zhao, Chun-Mei (Journal article; Peer reviewed, 2019)
      Background Bariatric surgery leads to early and long-lasting remission of type 2 diabetes (T2D). However, the mechanisms behind this phenomenon remain unclear. Among several factors, gut hormones are thought to be crucial ...

    • PYY plays a key role in the resolution of diabetes following bariatric surgery in humans 

      Sam D, Stephen; Claudia, Guida; Watson, Michael; Dempster, Niall; Larraufie, Pierre; Marjot, Thomas; Cargill, Tamsin; Rickers, Lisa; Pavlides, Michael; Tomlinson, Jeremy; Cobbold, Jeremy F.L.; Zhao, Chun-Mei; Chen, Duan; Gribble, Fiona M; Reimann, Frank; Gillies, Richard; Sgromo, Bruno; Rorsman, Patrik; Ryan, John D; Ramracheya, Reshma D. (Journal article; Peer reviewed, 2019)
      Background Bariatric surgery leads to early and long-lasting remission of type 2 diabetes (T2D). However, the mechanisms behind this phenomenon remain unclear. Among several factors, gut hormones are thought to be crucial ...