Blar i Institutt for klinisk og molekylær medisin på tidsskrift "Antimicrobial Agents and Chemotherapy"

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    • A novel antimycobacterial compound acts as an intracellular iron chelator 

      Dragset, Marte Singsås; Poce, Giovanna; Alfonso, Salvatore; Padilla-Benavides, Teresita; Ioerger, Thomas R.; Kaneko, Takushi; Sacchettini, James C.; Biava, Mariangela; Parish, Tanya; Argüello, José M.; Steigedal, Magnus; Rubin, Eric J. (Journal article; Peer reviewed, 2015)
      Efficient iron acquisition is crucial for the pathogenesis of Mycobacterium tuberculosis. Mycobacterial iron uptake and metabolism are therefore attractive targets for antitubercular drug development. Resistance mutations ...

    • Silenced vanA gene cluster on a transferable plasmid cause outbreak of vancomycin variable enterococci 

      Sivertsen, Audun; Pedersen, Torunn Annie; Larssen, Kjersti Wik; Bergh, Kåre; Rønning, Torunn Gresdal; Radtke, Andreas; Hegstad, Kristin (Journal article; Peer reviewed, 2016-05)
      We report an outbreak of vancomycin-variable vanA+ enterococci (VVE) able to escape phenotypic detection by current guidelines and demonstrate the molecular mechanisms for in vivo switching into vancomycin resistance and ...