Blar i Institutt for klinisk og molekylær medisin på forfatter "Pan, Qiuwei"
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Combating pan-coronavirus infection by indomethacin through simultaneously inhibiting viral replication and inflammatory response
Wang, Yining; Li, Pengfei; Xu, Lei; de Vries, Annemarie C.; Rottier, Robbert J.; Wang, Wenshi; Crombag, Marie-Rose B.S.; Peppelenbosch, Maikel P.; Kaynov, Denis; Pan, Qiuwei (Peer reviewed; Journal article, 2023)Severe infections with coronaviruses are often accompanied with hyperinflammation, requiring therapeutic strategies to simultaneously tackle the virus and inflammation. By screening a safe-in-human broad-spectrum antiviral ... -
Mono- and combinational drug therapies for global viral pandemic preparedness
Ianevski, Aleksandr; Yao, Rouan; Simonsen, Ronja Meyer; Myhre, Vegard; Ravlo, Erlend; Kaynova, Gerda D.; Zusinaite, Eva; White, Judith M.; Polyak, Stephen J.; Oksenych, Valentyn; Windisch, Marc P.; Pan, Qiuwei; Lastauskienė, Eglė; Vitkauskienė, Astra; Matukevičius, Algimantas; Tenson, Tanel; Bjørås, Magnar; Kainov, Denis (Peer reviewed; Journal article, 2022)Broadly effective antiviral therapies must be developed to be ready for clinical trials, which should begin soon after the emergence of new life-threatening viruses. Here, we pave the way towards this goal by reviewing ... -
Recapitulating hepatitis E virus-host interactions and facilitating antiviral drug discovery in human liver-derived organoids
Li, Pengfei; Li, Yunlong; Wang, Yijin; Liu, Jiaye; Lavrijsen, Marla; Li, Yang; Zhang, Ruyi; Verstegen, Monique M.A.; Wang, Yining; Li, Tian-Cheng; Ma, Zhongren; Kainov, Denis; Bruno, Marco J.; de Man, Robert A.; van der Laan, Luc J.W.; Peppelenbosch, Maikel P.; Pan, Qiuwei (Peer reviewed; Journal article, 2022)Hepatotropic viruses naturally have narrow host and tissue tropisms, challenging the development of robust experimental models. The advent of organoid technology provides a unique opportunity for moving the field forward. ...