Blar i Institutt for klinisk og molekylær medisin på forfatter "Mai, Xiao-Mei"
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Adiposity and asthma in adults: a bidirectional Mendelian randomization analysis of the HUNT Study
Sun, Yi-Qian; Brumpton, Ben Michael; Langhammer, Arnulf; Chen, Yue; Kvaløy, Kirsti; Mai, Xiao-Mei (Journal article; Peer reviewed, 2019)Background We aimed to investigate the potential causal associations of adiposity with asthma overall, asthma by atopic status or by levels of symptom control in a large adult population and stratified by sex. We also ... -
Age at Menarche, age at Natural Menopause, and Risk of Lung and Colorectal Cancers: A Mendelian Randomization Study
Dénos, Marion Nicole Marie; Sun, Yi-Qian; Jiang, Lin; Brumpton, Ben Michael; Mai, Xiao-Mei (Peer reviewed; Journal article, 2023)Background: The roles of age at menarche and age at menopause in the etiology of lung and colorectal cancers are unclear. Objective: We aimed to investigate potential causal associations between age at menarche, age at ... -
Assessing the role of genome-wide DNA methylation between smoking and risk of lung cancer using repeated measurements: the HUNT Study
Sun, Yi-Qian; Richmond, Rebecca C.; Suderman, Matthew; Min, Josine L; Battram, Thomas; Flatberg, Arnar; Beisvag, Vidar; Nøst, Therese Haugdahl; Guida, Florence; Jiang, Lin; Wahl, Sissel Gyrid Freim; Langhammer, Arnulf; Skorpen, Frank; Walker, Rosie M; Bretherick, Andrew D; Zeng, Yanni; Chen, Yue; Johansson, Mattias; Sandanger, Torkjel M; Relton, Caroline L; Mai, Xiao-Mei (Peer reviewed; Journal article, 2021)Background: It is unclear if smoking-related DNA methylation represents a causal pathway between smoking and risk of lung cancer. We sought to identify novel smoking-related DNA methylation sites in blood, with repeated ... -
Associations of serum 25-hydroxyvitamin D level with incidence of lung cancer and histologic types in Norwegian adults: a case-cohort analysis of the HUNT study
Sun, Yi-Qian; Langhammer, Arnulf; Wu, Chunsen; Skorpen, Frank; Chen, Yue; Nilsen, Tom Ivar Lund; Romundstad, Pål Richard; Mai, Xiao-Mei (Journal article, 2017)Background: Previous prospective studies have shown inconsistent associations between serum 25-hydroxyvitamin D [25(OH)D] level and lung cancer incidence. The aim of the present study was to explore the associations of ... -
Asthma and asthma symptom control in relation to incidence of lung cancer in the HUNT study
Jiang, Lin; Sun, Yi-Qian; Langhammer, Arnulf; Brumpton, Ben Michael; Chen, Yu; Nilsen, Tom Ivar Lund; Leivseth, Linda; Wahl, Sissel Gyrid Freim; Mai, Xiao-Mei (Peer reviewed; Journal article, 2021)Large prospective studies on asthma, especially asthma symptom control, as a potential risk factor for lung cancer are limited. We followed up 62,791 cancer-free Norwegian adults from 1995–1997 to 2017. Self-reported ... -
Body mass index and all cause mortality in HUNT and UK Biobank studies: linear and non-linear mendelian randomisation analyses
Sun, Yi-Qian; Burgess, Stephen; Staley, James R.; Wood, Angela M.; Bell, Steven; Kaptoge, Stephen; Guo, Qi; Bolton, Thomas R.; Mason, Amy M; Butterworth, Adam S.; Di Angelantonio, Emanuele; Vie, Gunnhild Åberge; Bjørngaard, Johan Håkon; Kinge, Jonas Minet; Chen, Yue; Mai, Xiao-Mei (Journal article; Peer reviewed, 2019)Objective To investigate the shape of the causal relation between body mass index (BMI) and mortality. Design Linear and non-linear mendelian randomisation analyses. Setting Nord-Trøndelag Health (HUNT) Study (Norway) ... -
Body mass index and incidence of lung cancer in the HUNT study: using observational and Mendelian randomization approaches
Jiang, Lin; Sun, Yi-Qian; Brumpton, Ben Michael; Langhammer, Arnulf; Chen, Yue; Mai, Xiao-Mei (Peer reviewed; Journal article, 2022)Background Traditional observational studies have shown an inverse association between body mass index (BMI) and lung cancer risk. Mendelian randomization (MR) analysis using genetic variants as instruments for BMI may ... -
Estimated cardiorespiratory fitness in relation to overall, breast and prostate cancer incidence: The Norwegian HUNT Study
Wang, Jin; Mai, Xiao-Mei; Sun, Yi-Qian (Peer reviewed; Journal article, 2022)Purpose To investigate the relationships between the estimated cardiorespiratory fitness (eCRF) and the incidence of overall, breast, and prostate cancer in a large prospective cohort study. Methods We included ... -
Hours lying down per day, as a proxy for sedentary behaviour and risk of diabetes in young and middle-aged adults in Norway: an 11-year follow-up of the HUNT study
Asante, Ernest O; Sun, Yi-Qian; Nilsen, Tom Ivar Lund; Åsvold, Bjørn Olav; Sørgjerd, Elin Pettersen; Mai, Xiao-Mei (Peer reviewed; Journal article, 2020)Objective We aimed to examine relationship between hours lying down per day, as a proxy for sedentary behaviour and risk of diabetes in young and middle-aged adults, and to assess if leisure-time physical activity and body ... -
Increased expression of individual genes in whole blood is associated with late-stage lung cancer at and close to diagnosis
Urbarova, Ilona Halva; Skogholt, Anne Heidi; Sun, Yi-Qian; Mai, Xiao-Mei; Grønberg, Bjørn Henning; Sandanger, Torkjel Manning; Sætrom, Pål; Nøst, Therese Haugdahl (Peer reviewed; Journal article, 2023)Lung cancer (LC) mortality rates are still increasing globally. As survival is linked to stage, there is a need to identify markers for earlier LC diagnosis and individualized treatment. The whole blood transcriptome of ... -
Mixed evidence for the relationship between periodontitis and Alzheimer’s disease: A bidirectional Mendelian randomization study
Sun, Yi-Qian; Richmond, Rebecca C.; Chen, Yue; Mai, Xiao-Mei (Journal article; Peer reviewed, 2020)Recent experimental studies indicated that a periodontitis-causing bacterium might be a causal factor for Alzheimer’s disease (AD). We applied a two-sample Mendelian randomization (MR) approach to examine the potential ... -
Potential causal associations of serum 25-hydroxyvitamin D with lipids: a Mendelian randomization approach of the HUNT study
Mai, Xiao-Mei; Videm, Vibeke; Sheehan, Nuala A.; Chen, Yue; Langhammer, Arnulf; Sun, Yi-Qian (Journal article; Peer reviewed, 2018)Background: Observational studies have shown consistent associations between higher circulating 25-hydroxyvitamin D [25(OH)D] levels and favorable serum lipids. We sought to investigate if such associations were causal. ... -
Reproductive factors in relation to incidence of lung and colorectal cancers in a Norwegian women cohort: the HUNT Study
Denos, Marion; Sun, Yi-Qian; Brumpton, Ben Michael; Langhammer, Arnulf; Chen, Yue; Mai, Xiao-Mei (Peer reviewed; Journal article, 2022)Context: The roles of reproductive factors in the etiology of lung and colorectal cancers, among the most common cancers in women, are unclear. Objective: We aimed to explore whether female reproductive factors were ... -
Serum 25-hydroxyvitamin D level in relation to weight change and the risk of weight gain in adults of normal weight at baseline: the Norwegian HUNT cohort study
Heitz, Adaline; Mai, Xiao-Mei; Chen, Yue; Sun, Yi-Qian (Peer reviewed; Journal article, 2020)Objective We sought to investigate the relationship of serum 25-hydroxyvitamin D (25(OH)D) level with weight change and the risk of weight gain in an adult population who had normal weight at baseline and were followed up ... -
Serum 25-hydroxyvitamin D level in relation to weight change and the risk of weight gain in adults of normal weight at baseline: the Norwegian HUNT cohort study
Heitz, Adaline; Mai, Xiao-Mei; Chen, Yue; Sun, Yi-Qian (Peer reviewed; Journal article, 2020)Objective We sought to investigate the relationship of serum 25-hydroxyvitamin D (25(OH)D) level with weight change and the risk of weight gain in an adult population who had normal weight at baseline and were followed up ... -
Serum 25-hydroxyvitamin D level, chronic diseases and all-cause mortality in a population-based prospective cohort: the HUNT Study, Norway
Sun, Yi-Qian; Langhammer, Arnulf; Skorpen, Frank; Chen, Yue; Mai, Xiao-Mei (Journal article; Peer reviewed, 2017)Objective: To investigate the association of vitamin D status with all-cause mortality in a Norwegian population and the potential influences of existing chronic diseases on the association. Design: A population-based ... -
Serum 25-hydroxyvitamin D levels and risk of lung cancer and histologic types: a Mendelian randomization analysis of the HUNT study
Sun, Yi-Qian; Brumpton, Ben Michael; Bonilla, Carolina; Lewis, Sarah J.; Burgess, Stephen; Skorpen, Frank; Chen, Yue; Nilsen, Tom Ivar Lund; Romundstad, Pål Richard; Mai, Xiao-Mei (Journal article; Peer reviewed, 2018)We aimed to investigate potential causal associations between serum 25-hydroxyvitamin D [25(OH)D] levels and incidence of lung cancer overall and histologic types. We performed a Mendelian randomization (MR) analysis using ... -
Vitamin D status and risk of type 2 diabetes in the Norwegian HUNT cohort study: Does family history or genetic predisposition modify the association?
Denos, Marion; Mai, Xiao-Mei; Åsvold, Bjørn Olav; Sørgjerd, Elin Pettersen; Chen, Yue; Sun, Yi-Qian (Peer reviewed; Journal article, 2021)Introduction We sought to investigate the relationship between serum 25-hydroxyvitamin D (25(OH)D) level and the risk of type 2 diabetes mellitus (T2DM) in adults who participated in the Trøndelag Health Study (HUNT), and ... -
Vitamin D Status Over Time and Cognitive Function in Norwegian Older Adults: A Prospective Cohort of the HUNT Study
Asante, Ernest Obeng; Mai, Xiao-Mei; Eldholm, Rannveig Sakshaug; Skjellegrind, Håvard; Kolberg, Marit; Brumpton, Ben Michael; Selbæk, Geir; Chen, Y.; Sun, Yi-Qian (Peer reviewed; Journal article, 2022)Background There is conflicting evidence regarding the association between vitamin D status and cognitive function in population studies. The use of one-time vitamin D measurement in cognitive health studies may not ...