Blar i Institutt for klinisk og molekylær medisin på forfatter "Jakobsen, Gunnhild"
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Antibiotic Therapy in Integrated Oncology and Palliative Cancer Care: An Observational Study
Moen, Martine Kjølberg; Løhre, Erik T; Jakobsen, Gunnhild; Thronæs, Morten; Klepstad, Pål (Peer reviewed; Journal article, 2022)Simple Summary Approximately one-quarter of the patients with advanced cancer acutely admitted to the Palliative Care Unit at St. Olav’s University Hospital received intravenous antibiotics. We observed that physiological ... -
Breakthrough and Episodic Cancer Pain from a Palliative Care Perspective
Løhre, Erik Torbjørn; Jakobsen, Gunnhild; Solheim, Tora Skeidsvoll; Klepstad, Pål; Thronæs, Morten (Peer reviewed; Journal article, 2023)Cancer pain intensity (PI) fluctuates, but the relationship between pain flares and background pain with respect to pain management is not settled. We studied how flare and background PIs corresponded with treatment results ... -
Emergency Palliative Cancer Care: Dexmedetomidine Treatment Experiences—A Retrospective Brief Report on Nine Consecutive Cases
Løhre, Erik Torbjørn; Svedahl, Augstein; Jakobsen, Gunnhild; Solheim, Tora S; Klepstad, Pål; Thronæs, Morten (Peer reviewed; Journal article, 2023)Introduction Dexmedetomidine, an alpha-2 adrenergic receptor agonist with potential opioid sparing properties, is utilized in palliative medicine, but the knowledge base for this practice is limited. We describe concomitant ... -
Interventions and symptom relief in hospital palliative cancer care: results from a prospective longitudinal study
Thronæs, Morten; Løhre, Erik T; Kvikstad, Anne; Brenne, Elisabeth; Norvaag, Robin; Aalberg, Kathrine Otelie; Moen, Martine Kjølberg; Jakobsen, Gunnhild; Klepstad, Pål; Solberg, Arne; Solheim, Tora S (Journal article; Peer reviewed, 2021)Purpose To study the use of interventions and symptom relief for adult patients with incurable cancer admitted to an acute palliative care unit providing integrated oncology and palliative care services. Methods All ... -
Mild to Moderate Cognitive Impairment Does Not Affect the Ability to Self-Report Important Symptoms in Patients With Cancer: A Prospective Longitudinal Multinational Study (EPCCS)
Ekström, Magnus P.; Palmqvist, Sebastian; Currow, David C.; Sjøgren, Per; Kurita, Geana Paula; Jakobsen, Gunnhild; Kaasa, Stein; Hjermstad, Marianne Jensen (Peer reviewed; Journal article, 2020)Context Patients with advanced cancer commonly suffer from both distressing symptoms and cognitive impairment, but the effect of cognitive impairment on the reliability and validity of symptom self-report is unknown. ... -
Physical function endpoints in cancer cachexia clinical trials: Systematic Review 1 of the cachexia endpoints series
McDonald, James; Sayers, Judith; Anker, Stefan D.; Arends, Jann; Balstad, Trude Rakel; Baracos, Vickie; Brown, Leo; Bye, Asta; Dajani, Olav; Dolan, Ross; Fallon, Marie T.; Fraser, Eilidh; Griel, Christine; Grzyb, Aleksandra; Hjermstad, Marianne Jensen; Jamal-Hanjani, Mariam; Jakobsen, Gunnhild; Kaasa, Stein; McMillan, Donald; Maddocks, Matthew; Philips, Iain; Ottestad, Inger; Reid, Kieran F.; Sousa, Mariana S.; Simpson, Melanie Rae; Vagnildhaug, Ola Magne; Skipworth, Richard J. E.; Solheim, Tora S; Laird, Barry J (Peer reviewed; Journal article, 2023)In cancer cachexia trials, measures of physical function are commonly used as endpoints. For drug trials to obtain regulatory approval, efficacy in physical function endpoints may be needed alongside other measures. However, ... -
The short-term impact of methylprednisolone on patient-reported sleep in patients with advanced cancer in a randomized, placebo-controlled, double-blind trial
Jakobsen, Gunnhild; Engstrøm, Morten; Hjermstad, Marianne Jensen; Rosland, Jan Henrik; Aass, Nina Kathrine; Albert, Eva; Kaasa, Stein; Fayers, Peter; Klepstad, Pål; Paulsen, Ørnulf (Peer reviewed; Journal article, 2020)Purpose: Although corticosteroids are frequently used in patients with advanced cancer, few studies have examined the impact of these drugs on patient-reported sleep. We aimed to examine the short-term impact of ... -
Sleep in patients with advanced cancer
Jakobsen, Gunnhild (Doctoral theses at NTNU;2019:298, Doctoral thesis, 2019) -
Sleep quality in hospitalized patients with advanced cancer: an observational study using self-reports of sleep and actigraphy
Jakobsen, Gunnhild; Engstrøm, Morten; Thronæs, Morten; Løhre, Erik Torbjørn; Kaasa, Stein; Fayers, Peter; Hjermstad, Marianne Jensen; Klepstad, Pål (Journal article; Peer reviewed, 2019)Purpose Although patients with advanced cancer report poor sleep quality, few studies have assessed sleep quality with a combination of subjective and objective measures. We aimed to examine sleep quality in hospitalized ... -
Sleep quality with WHO Step III opioid use for cancer pain
Jakobsen, Gunnhild; Engstrøm, Morten; Fayers, Peter; Hjermstad, Marianne Jensen; Kaasa, Stein; Kloke, Marianne; Sabatowski, Rainer; Klepstad, Pål (Journal article; Peer reviewed, 2018)Objective Sleep is often disturbed in patients with advanced cancer. There is limited knowledge about sleep in patients with cancer treated with strong opioids. This study examines sleep quality in patients with advanced ... -
Zopiclone versus placebo for short-term treatment of insomnia in patients with advanced cancer: study protocol for a double-blind, randomized, placebo-controlled, clinical multicenter trial
Jakobsen, Gunnhild; Engstrøm, Morten; Paulsen, Ørnulf; Sjue, Karin; Raj, Sunil Xavier; Thronæs, Morten; Hjermstad, Marianne Jensen; Kaasa, Stein; Fayers, Peter; Klepstad, Pål (Journal article; Peer reviewed, 2018)Background Despite the high prevalence of insomnia in patients with advanced cancer, there are no randomized controlled trials on pharmacological interventions for insomnia in this group of patients. A variety of ...