Blar i Institutt for klinisk og molekylær medisin på forfatter "Carlsen, Sven Magnus"
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A Review of the Current Challenges Associated with the Development of an Artificial Pancreas by a Double Subcutaneous Approach
Christiansen, Sverre; Fougner, Anders Lyngvi; Stavdahl, Øyvind; Kölle, Konstanze; Ellingsen, Reinold; Carlsen, Sven Magnus (Journal article; Peer reviewed, 2017)Introduction Patients with diabetes type 1 (DM1) struggle daily to achieve good glucose control. The last decade has seen a rush of research groups working towards an artificial pancreas (AP) through the application of a ... -
The Artificial Pancreas: Two Alternative Approaches to Achieve a Fully Closed Loop System with Optimal Glucose Control
Åm, Marte Kierulf; Teigen, Ingrid Anna; Riaz, Misbah; Fougner, Anders Lyngvi; Christiansen, Sverre Christian; Carlsen, Sven Magnus (Peer reviewed; Journal article, 2023)Introduction Diabetes mellitus type 1 is a chronic disease that implies mandatory external insulin delivery. The patients must monitor their blood glucose levels and administer appropriate insulin boluses to keep their ... -
Basic lifestyle advice to individuals at high risk of type 2 diabetes: a 2-year population-based diabetes prevention study. The DE-PLAN intervention in the HUNT Study, Norway
Jølle, Anne; Åsvold, Bjørn Olav; Holmen, Jostein; Carlsen, Sven Magnus; Tuomilehto, Jaakko; Bjørngaard, Johan Håkon; Midthjell, Kristian (Journal article; Peer reviewed, 2018)Objective Among individuals at high risk for diabetes identified through a population survey, we performed an intervention study with basic lifestyle advice aiming to prevent diabetes. Research design and methods Among ... -
Comparative effectiveness of microdecompression and laminectomy for central lumbar spinal stenosis: Study protocol for an observational study
Nerland, Ulf Skule; Jakola, Asgeir Store; Solheim, Ole; Weber, Clemens; Rao, Vidar; Lønne, Greger; Solberg, Tore; Salvesen, Øyvind; Carlsen, Sven Magnus; Nygaard, Øystein Petter; Gulati, Sasha (Journal article; Peer reviewed, 2014)Introduction: This observational study is designed to test the equivalence between the clinical effectiveness of microdecompression and laminectomy in the surgical treatment of central lumbar spinal stenosis. Lumbar spinal ... -
Differences Between Flash Glucose Monitor and Fingerprick Measurements
Staal, Odd Martin; Hansen, Heidi Marie Umbach; Christiansen, Sverre; Fougner, Anders Lyngvi; Carlsen, Sven Magnus; Stavdahl, Øyvind (Journal article; Peer reviewed, 2018)Freestyle Libre (FL) is a factory calibrated Flash Glucose Monitor (FGM). We investigated Mean Absolute Relative Difference (MARD) between Self Monitoring of Blood Glucose (SMBG) and FL measurements in the first day of ... -
Disulfiram repurposing combined with nutritional copper supplement as add-on to chemotherapy in recurrent glioblastoma (DIRECT): Study protocol for a randomized controlled trial
Jakola, Asgeir S.; Werlenius, Katja; Mudaisi, Munila; Hylin, Sofia; Kinhult, Sara; bartek, Jiri Jr.; Salvesen, Øyvind; Carlsen, Sven Magnus; Strandeus, Michael; Lindskog, Magnus; Lofgren, David; Rydenhaug, Bertil; Carstam, Louise; Gulati, Sasha; Solheim, Ole; Bartek, Jiri; Solheim, Tora Skeidsvoll (Journal article; Peer reviewed, 2018)Background: Disulfiram (DSF) is a well-tolerated, inexpensive, generic drug that has been in use to treat alcoholism since the 1950s. There is now independent preclinical data that supports DSF as an anticancer agent, and ... -
Does AMH Reflect Follicle Number Similarly in Women with and without PCOS?
Christiansen, Sverre Christian; Eilertsen, Tina Bjørsvik; Vanky, Eszter; Carlsen, Sven Magnus (Journal article; Peer reviewed, 2016-01-22)Context: Increased Anti-Mullerian Hormone in polycystic ovary syndrome, may be due to overactive follicles rather than reflect antral follicle count. Objective: Does Anti-Mullerian Hormone reflect antral follicle ... -
The effect of glucagon on local subcutaneous blood flow in non-diabetic volunteers; a proof-of-concept study
Åm, Marte Kierulf; Munkerud, Erlend Yttersian; Berge, Mathilde Hallem; Christiansen, Sverre Christian; Carlsen, Sven Magnus (Peer reviewed; Journal article, 2022)Introduction Glucagon and insulin are the two most important hormones for glucose metabolism and have been incorporated in the dual-hormonal artificial pancreas, a device for automated glucose regulation for people with ... -
Effect of sensor location on continuous intraperitoneal glucose sensing in an animal model
Åm, Marte Kierulf; Kölle, Konstanze; Fougner, Anders Lyngvi; Dirnena-Fusini, Ilze; Bösch, Patrick Christian; Ellingsen, Reinold; Hjelme, Dag Roar; Stavdahl, Øyvind; Carlsen, Sven Magnus; Christiansen, Sverre (Journal article; Peer reviewed, 2018)In diabetes research, the development of the artificial pancreas has been a major topic since continuous glucose monitoring became available in the early 2000’s. A prerequisite for an artificial pancreas is fast and reliable ... -
Effect of Spinal Cord Burst Stimulation vs Placebo Stimulation on Disability in Patients With Chronic Radicular Pain After Lumbar Spine Surgery: A Randomized Clinical Trial
Hara, Sozaburo; Andresen, Hege; Solheim, Ole; Carlsen, Sven Magnus; Sundstrøm, Terje; Lønne, Greger; Vangen-Lønne, Vetle; Taraldsen, Kristin; Tronvik, Erling Andreas; Øie, Lise Rystad; Gulati, Agnete Malm; Sagberg, Lisa Millgård; Jakola, Asgeir Store; Solberg, Tore; Nygaard, Øystein Petter; Salvesen, Øyvind; Gulati, Sasha (Peer reviewed; Journal article, 2022)Importance: The use of spinal cord stimulation for chronic pain after lumbar spine surgery is increasing, yet rigorous evidence of its efficacy is lacking. Objective: To investigate the efficacy of spinal cord burst ... -
Enhancement of Insulin Absorption by Local Manipulation of the Site of Injection
Finne, Solveig Nyland (Master thesis, 2019)Bakgrunn: Trege og uforutsigbare absorpsjonsprofiler av subkutant injiserte måltidsinsuliner er ansett som en stor utfordring i behandlingen av diabetes type 1, og resulterer ofte i en forsinket topp og en langvarig ... -
Feasibility of early meal detection based on abdominal sound.
Kölle, Konstanze; Fougner, Anders Lyngvi; Ellingsen, Reinold; Carlsen, Sven Magnus; Stavdahl, Øyvind (Journal article; Peer reviewed, 2019)Background In classical approaches for an artificial pancreas, continuous glucose monitoring (CGM) is the only measured variable used for insulin dosing and additional control functions. The CGM values are subject to time ... -
HbA1c as screening for gestational diabetes mellitus in women with polycystic ovary syndrome
Odsæter, Ingrid Hov; Åsberg, Arne; Vanky, Eszter; Carlsen, Sven Magnus (Journal article; Peer reviewed, 2015)Background Gestational diabetes mellitus (GDM) is associated with adverse pregnancy outcomes such as preeclampsia and macrosomia. Women with polycystic ovary syndrome (PCOS) are at increased risk of developing GDM. ... -
Hemoglobin A1c as screening for gestational diabetes mellitus in Nordic Caucasian women
Odsæter, Ingrid Hov; Åsberg, Arne; Vanky, Eszter; Mørkved, Siv; Stafne, Signe Nilssen; Salvesen, Kjell Å; Carlsen, Sven Magnus (Peer reviewed; Journal article, 2016)Background Gestational diabetes mellitus (GDM) increases the risk for preeclampsia and macrosomia. GDM is conventionally diagnosed by an oral glucose tolerance test (OGTT). Hemoglobin A1c (HbA1c) is a marker for the ... -
Hemoglobin A1c in screening for gestational diabetes mellitus - Diagnostic accuracy studies and analytical considerations
Odsæter, Ingrid Hov (Doctoral theses at NTNU;2017:269, Doctoral thesis, 2017) -
Incidence and Case Fatality of Aneurysmal Subarachnoid Hemorrhage Admitted to Hospital Between 2008 and 2014 in Norway
Øie, Lise Rystad; Solheim, Ole; Majewska, Paulina Luiza; Nordseth, Trond; Müller, Tomm Brostrup; Carlsen, Sven Magnus; Jensberg, Heidi; Salvesen, Øyvind; Gulati, Sasha (Peer reviewed; Journal article, 2020)Background To provide age- and sex-specific incidence and case fatality rates for non-traumatic aneurysmal subarachnoid hemorrhage (aSAH) in Norway. We also studied time trends in incidence and case fatality, as well as ... -
Intraperitoneal and subcutaneous glucagon delivery in anaesthetized pigs: effects on circulating glucagon and glucose levels
Åm, Marte Kierulf; Dirnena-Fusini, Ilze; Fougner, Anders Lyngvi; Carlsen, Sven Magnus; Christiansen, Sverre (Journal article; Peer reviewed, 2020)Glucagon is a pancreatic hormone and increases the blood glucose levels. It may be incorporated in a dual hormone artificial pancreas, a device to automatically and continuously control blood glucose levels of individuals ... -
The intraperitoneal artificial pancreas: glucose sensing and glucagon delivery
Åm, Marte Kierulf (Doctoral theses at NTNU;2020:267, Doctoral thesis, 2020)Norsk sammendrag Diabetes er en gruppe sykdommer som globalt rammer millioner av mennesker. Denne avhandlingen fokuserer på diabetes mellitus type 1 som kjennetegnes av ingen, eller veldig liten, produksjon av insulin. ... -
Intraperitoneal insulin administration - superior choice for an artificial pancreas?
Dirnena-Fusini, Ilze (Doctoral theses at NTNU;2021:334, Doctoral thesis, 2021)The main focus of this thesis is to explore the intraperitoneal (IP) cavity as the location for insulin administration. We hypothesized that IP insulin administration is more physiologic as it mimics endogenous insulin ... -
Intraperitoneal insulin administration in pigs: Effect on circulating insulin and glucose levels
Dirnena-Fusini, Ilze; Åm, Marte Kierulf; Fougner, Anders Lyngvi; Carlsen, Sven Magnus; Christiansen, Sverre Christian (Peer reviewed; Journal article, 2021)Introduction The effect of intraperitoneal insulin infusion has limited evidence in the literature. Therefore, the aim of the study was to investigate the pharmacokinetics and pharmacodynamics of different intraperitoneal ...