Blar i Institutt for klinisk og molekylær medisin på tidsskrift "FEBS Open Bio"
Viser treff 1-5 av 5
-
Genetic interaction between DNA repair factors PAXX, XLF, XRCC4 and DNA-PKcs in human cells
(Journal article; Peer reviewed, 2019)DNA double‐strand breaks (DSBs) are highly cytotoxic lesions, and unrepaired or misrepaired DSBs can lead to various human diseases, including immunodeficiency, neurological abnormalities, growth retardation, and cancer. ... -
Nephronectin mediates p38 MAPK‐induced cell viability via its integrin binding enhancer motif
(Journal article; Peer reviewed, 2018)Nephronectin (NPNT) is an extracellular matrix (ECM) protein involved in kidney development. We recently reported intracellular NPNT as a potential prognostic marker in breast cancer and that NPNT promotes metastasis in ... -
Normal development of mice lacking PAXX, the paralogue of XRCC4 and XLF
(Journal article; Peer reviewed, 2018)DNA repair consists of several cellular pathways which recognize and repair damaged DNA. The classical nonhomologous DNA end-joining (NHEJ) pathway repairs double-strand breaks in DNA. It is required for maturation of both ... -
Robust DNA repair in PAXX-deficient mammalian cells
(Journal article; Peer reviewed, 2018)To ensure genome stability, mammalian cells employ several DNA repair pathways. Nonhomologous DNA end joining (NHEJ) is the DNA repair process that fixes double-strand breaks throughout the cell cycle. NHEJ is involved in ... -
The role of PCNA as a scaffold protein in cellular signaling is functionally conserved between yeast and humans
(Journal article; Peer reviewed, 2018)Proliferating cell nuclear antigen (PCNA), a member of the highly conserved DNA sliding clamp family, is an essential protein for cellular processes including DNA replication and repair. A large number of proteins from ...