Blar i Institutt for klinisk og molekylær medisin på tidsskrift "EBioMedicine"
Viser treff 1-7 av 7
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A Validated Clinical Risk Prediction Model for Lung Cancer in Smokers of All Ages and Exposure Types: A HUNT Study
(Journal article; Peer reviewed, 2018)Lung cancer causes >1·6 million deaths annually, with early diagnosis being paramount to effective treatment. Here we present a validated risk assessment model for lung cancer screening. The prospective HUNT2 population ... -
Cholesterol crystals use complement to increase NLRP3 signaling pathways in coronary and carotid atherosclerosis
(Peer reviewed; Journal article, 2020)Background: During atherogenesis, cholesterol precipitates into cholesterol crystals (CC) in the vessel wall, which trigger plaque inflammation by activating the NACHT, LRR and PYD domains-containing protein 3 (NLRP3) ... -
Fetal HLA-G mediated immune tolerance and interferon response in preeclampsia
(Peer reviewed; Journal article, 2020)Background Fetal immune tolerance is crucial for pregnancy success. We studied the link between preeclampsia, a severe pregnancy disorder with uncertain pathogenesis, and fetal human leukocyte antigen G (HLA-G) and other ... -
Interleukin-6 inhibition in ST-elevation myocardial infarction: Immune cell profile in the randomised ASSAIL-MI trial
(Peer reviewed; Journal article, 2022)We recently showed that interleukin (IL)-6 inhibition by tocilizumab improves myocardial salvage in ST-elevation myocardial infarction (STEMI). However, the mechanisms for this effect are not clear. Methods In this ... -
Metabolomics and Gene Expression Analysis Reveal Down-regulation of the Citric Acid (TCA) Cycle in Non-diabetic CKD Patients
(Journal article; Peer reviewed, 2017)Chronic kidney disease (CKD) is a public health problem with very high prevalence and mortality. Yet, there is a paucity of effective treatment options, partly due to insufficient knowledge of underlying pathophysiology. ... -
PYY Plays a Key Role in the Resolution of Diabetes Following Bariatric Surgery in Humans
(Journal article; Peer reviewed, 2019)Background Bariatric surgery leads to early and long-lasting remission of type 2 diabetes (T2D). However, the mechanisms behind this phenomenon remain unclear. Among several factors, gut hormones are thought to be crucial ... -
PYY plays a key role in the resolution of diabetes following bariatric surgery in humans
(Journal article; Peer reviewed, 2019)Background Bariatric surgery leads to early and long-lasting remission of type 2 diabetes (T2D). However, the mechanisms behind this phenomenon remain unclear. Among several factors, gut hormones are thought to be crucial ...