Browsing Institutt for klinisk og molekylær medisin by Journals "Scientific Reports"
Now showing items 1-20 of 78
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5-hydroxymethylcytosine marks mammalian origins acting as a barrier to replication
(Journal article; Peer reviewed, 2019)In most mammalian cells, DNA replication occurs once, and only once between cell divisions. Replication initiation is a highly regulated process with redundant mechanisms that prevent errant initiation events. In lower ... -
Abdominal adipose tissue and liver fat imaging in very low birth weight adults born preterm: birth cohort with sibling-controls
(Peer reviewed; Journal article, 2022)Preterm birth at very low birth weight (VLBW, < 1500 g) is associated with an accumulation of cardiovascular and metabolic risk factors from childhood at least to middle age. Small-scale studies suggest that this could ... -
Adaptor Template Oligo-Mediated Sequencing (ATOM-Seq) is a new ultra-sensitive UMI-based NGS library preparation technology for use with cfDNA and cfRNA
(Peer reviewed; Journal article, 2021)Liquid biopsy testing utilising Next Generation Sequencing (NGS) is rapidly moving towards clinical adoption for personalised oncology. However, before NGS can fulfil its potential any novel testing approach must identify ... -
Additive manufacturing of laminar flow cells for single-molecule experiments
(Journal article; Peer reviewed, 2019)A microfluidic laminar flow cell (LFC) forms an indispensable component in single-molecule experiments, enabling different substances to be delivered directly to the point under observation and thereby tightly controlling ... -
Antibiotic-induced DNA damage results in a controlled loss of pH homeostasis and genome instability
(Peer reviewed; Journal article, 2020)Extracellular pH has been assumed to play little if any role in how bacteria respond to antibiotics and antibiotic resistance development. Here, we show that the intracellular pH of Escherichia coli equilibrates to the ... -
Arabidopsis myrosinases link the glucosinolate-myrosinase system and the cuticle.
(Journal article; Peer reviewed, 2016)Both physical barriers and reactive phytochemicals represent two important components of a plant’s defence system against environmental stress. However, these two defence systems have generally been studied independently. ... -
Association between depression symptoms and moderately increased levels of the inflammation marker albuminuria is explained by age and comorbidity
(Peer reviewed; Journal article, 2022)The study aimed to examine whether there are associations between depression symptoms and levels of the inflammation marker albuminuria. The 8303 participants in this cross-sectional study were subjects from the second ... -
Association of smoking and cancer with the risk of venous thromboembolism: the Scandinavian Thrombosis and Cancer cohort
(Peer reviewed; Journal article, 2021)Smoking is a well-established risk factor for cancer, and cancer patients have a high risk of venous thromboembolism (VTE). Conflicting results have been reported on the association between smoking and risk of VTE, and the ... -
Associations between circulating microRNAs and lipid-rich coronary plaques measured with near-infrared spectroscopy
(Peer reviewed; Journal article, 2023)Lipid-rich coronary atherosclerotic plaques often cause myocardial infarction (MI), and circulating biomarkers that reflect lipid content may predict risk of MI. We investigated the association between circulating microRNAs ... -
Asthma and asthma symptom control in relation to incidence of lung cancer in the HUNT study
(Peer reviewed; Journal article, 2021)Large prospective studies on asthma, especially asthma symptom control, as a potential risk factor for lung cancer are limited. We followed up 62,791 cancer-free Norwegian adults from 1995–1997 to 2017. Self-reported ... -
Automated machine learning optimizes and accelerates predictive modeling from COVID-19 high throughput datasets
(Peer reviewed; Journal article, 2021)COVID-19 outbreak brings intense pressure on healthcare systems, with an urgent demand for effective diagnostic, prognostic and therapeutic procedures. Here, we employed Automated Machine Learning (AutoML) to analyze three ... -
Biochemical profiling of diabetes disease progression by multivariate vibrational microspectroscopy of the pancreas
(Journal article; Peer reviewed, 2017)Despite the dramatic increase in the prevalence of diabetes, techniques for in situ studies of the underlying pancreatic biochemistry are lacking. Such methods would facilitate obtaining mechanistic understanding of diabetes ... -
Body composition and physical fitness in adults born small for gestational age at term: a prospective cohort study
(Peer reviewed; Journal article, 2023)There is lack of research on body composition and physical fitness in individuals born small for gestational age (SGA) at term entering mid-adulthood. We aimed to investigate these outcomes in adults born SGA at term. This ... -
Cancer cachexia associates with a systemic autophagy-inducing activity mimicked by cancer cell-derived IL-6 trans-signaling
(Journal article; Peer reviewed, 2017)The majority of cancer patients with advanced disease experience weight loss, including loss of lean body mass. Severe weight loss is characteristic for cancer cachexia, a condition that significantly impairs functional ... -
Changes in C-reactive protein, neopterin and lactoferrin differ after conservative and surgical weight loss in individuals with morbid obesity
(Journal article; Peer reviewed, 2019)C-reactive protein, neopterin and lactoferrin are biomarkers of atherosclerotic disease. We aimed to assess changes in these biomarkers after conservative and surgical weight loss interventions in individuals with morbid ... -
Characterization of signaling pathways regulating the expression of pro-inflammatory long form thymic stromal lymphopoietin upon human metapneumovirus infection
(Journal article; Peer reviewed, 2018)Thymic stromal lymphopoietin (TSLP) is associated with several allergic diseases including asthma. Two isoforms of TSLP exist in humans, a long form (lfTSLP) and a short form (sfTSLP), displaying distinct immunological ... -
Childhood epilepsy and ADHD comorbidity in an Indian tertiary medical center outpatient population
(Journal article; Peer reviewed, 2018)This study aimed to assess the prevalence of Attention Deficit Hyperactivity Disorder (ADHD) and its characteristics and risk factors in children with epilepsy at a tertiary medical center in New Delhi. Children with active ... -
Detection and differentiation of breast cancer sub-types using a cPLA2a activatable fluorophore
(Journal article; Peer reviewed, 2019)Cytosolic phospholipase A2α (cPLA2α) has been shown to be elevated in breast cancer and is a potential biomarker in the differentiation of molecular sub-types. Using a cPLA2α activatable fluorophore, DDAO arachidonate, we ... -
Differential regulation of cysteine oxidative post-translational modifications in high and low aerobic capacity
(Journal article; Peer reviewed, 2018)Given the association between high aerobic capacity and the prevention of metabolic diseases, elucidating the mechanisms by which high aerobic capacity regulates whole-body metabolic homeostasis is a major research challenge. ... -
Evaluation of hypoglycaemia with non-invasive sensors in people with type 1 diabetes and impaired awareness of hypoglycaemia
(Journal article; Peer reviewed, 2018)People with type 1 diabetes and impaired awareness of hypoglycaemia (IAH) are prone to severe hypoglycaemia. Previous attempts to develop non-invasive hypoglycaemia alarm systems have shown promising results, but it is not ...