Browsing Institutt for klinisk og molekylær medisin by Journals "Chemical Science"
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Picomolar FKBP inhibitors enabled by a single water-displacing methyl group in bicyclic [4.3.1] aza-amides
(Journal article; Peer reviewed, 2021)Methyl groups can have profound effects in drug discovery but the underlying mechanisms are diverse and incompletely understood. Here we report the stereospecific effect of a single, solvent-exposed methyl group in bicyclic ...